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anti-Human UBE2N Antibodies:
anti-Mouse (Murine) UBE2N Antibodies:
anti-Rat (Rattus) UBE2N Antibodies:
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Human Polyclonal UBE2N Primary Antibody for IP, WB - ABIN252335
Ewart-Toland, Briassouli, de Koning, Mao, Yuan, Chan, MacCarthy-Morrogh, Ponder, Nagase, Burn, Ball, Almeida, Linardopoulos, Balmain: Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. in Nature genetics 2003
Show all 3 Pubmed References
Human Polyclonal UBE2N Primary Antibody for IHC (p), WB - ABIN2477023
Flowers, Horan, Wylds, Crawford, Sridharan, Horan, Cliff: Relation of peri-infarction block to ventricular late potentials in patients with inferior wall myocardial infarction. in The American journal of cardiology 1990
Show all 3 Pubmed References
Human Polyclonal UBE2N Primary Antibody for IHC (fro), WB - ABIN550264
Vogel, Fitzgerald, Fenton: TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. in Molecular interventions 2004
Show all 2 Pubmed References
Cow (Bovine) Polyclonal UBE2N Primary Antibody for IHC, WB - ABIN2778258
Bothos, Summers, Venere, Scolnick, Halazonetis: The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. in Oncogene 2003
Show all 2 Pubmed References
Human Polyclonal UBE2N Primary Antibody for ELISA, ICC - ABIN4363945
Masuda, Suzuki, Kawai, Hishiki, Hashimoto, Masutani, Hishida, Suzuki, Kamiya: En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs. in Nucleic acids research 2012
The malin (show NHLRC1 Antibodies)-laforin (show EPM2A Antibodies) complex interacts physically and functionally with the ubiquitin conjugating enzyme E2-N (UBE2N).
Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2 (show UBE2V2 Antibodies)) and ring finger protein 4 (RNF4 (show RNF4 Antibodies)) together induce an active conformation of the ubiquitin-conjugating enzyme (show Ube2t Antibodies) Ubc13-ubiquitin (Ubc13~Ub) thioester.
together with UBE2L3 (show UBE2L3 Antibodies) and UBE2D2 (show UBE2D2 Antibodies), synergistically contribute to Parkin (show PARK2 Antibodies)-mediated mitophagy
MiR (show MLXIP Antibodies)-205 inhibits DNA damage repair by targeting ZEB1 (show ZEB1 Antibodies) and Ubc13.
Ubiquitin-conjugating enzyme (show Ube2t Antibodies) complex Uev1A (show UBE2V1 Antibodies)-Ubc13 promotes breast cancer metastasis through nuclear factor-small ka, CyrillicB mediated matrix metalloproteinase-1 (show MMP1 Antibodies) gene regulation.
Ubc13 was dispensable for transforming growth factor beta (TGFbeta (show TGFB1 Antibodies))-induced SMAD (show SMAD1 Antibodies) activation but was required for activation of non-SMAD (show SMAD1 Antibodies) signaling via TGFbeta (show TGFB1 Antibodies)-activating kinase 1 (TAK1 (show MAP3K7 Antibodies)) and p38 (show CRK Antibodies)
UBE2N inhibition induces neuroblastoma (show ARHGEF16 Antibodies) apoptotic cell death via activation of p53 (show TP53 Antibodies) and JNK (show MAPK8 Antibodies) pathways.
overexpression of hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-4516 downregulates STAT3 (show STAT3 Antibodies), p-STAT3 (show STAT3 Antibodies), CDK6 (show CDK6 Antibodies), and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells.
crystal structure of the Shigella flexneri OspI-Ubc13 complex at 2.3 A resolution; study reveals the molecular basis of Ubc13 deamidation by OspI, as well as a convergence of E2 recognition by bacterial and host proteins
The structure of the Shigella flexneri OspI and human Ubc13 complex revealed that the interacting surfaces between OspI and Ubc13 are a hydrophobic surface and a complementary charged surface.
GPS2 (show GPS2 Antibodies) is required for restricting the activation of TLR and BCR (show BCR Antibodies) signaling pathways and the AKT (show AKT1 Antibodies)/FOXO1 (show FOXO1 Antibodies) pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity
RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
Overexpressing UBE2N increases the aggregation of mutant huntingtin (show HTT Antibodies), and reducing UBE2N attenuates huntingtin (show HTT Antibodies) aggregation in cellular and mouse models of Huntington's disease.
STAT3 (show STAT3 Antibodies) restrains RANKL (show TNFSF11 Antibodies)- and TLR4 (show TLR4 Antibodies)-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme (show UBE2L6 Antibodies) Ubc13.
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
These results establish Ubc13 as a crucial regulator of hematopoiesis and suggest a role for Ubc13 in the control of Wnt (show WNT2 Antibodies) signaling in hematopoietic stem cells.
Ubc13 is key in the mammalian immune response.
Ubiquitin-conjugating enzyme (show Ube2t Antibodies) Ubc13 is a critical component of TNF (show TNF Antibodies) receptor-associated factor (TRAF (show TRAF1 Antibodies))-mediated inflammatory responses.
modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
ubiquitin-conjugating enzyme E2N (UBC13 homolog)
, ubiquitin-conjugating enzyme E2N
, ubiquitin-conjugating enzyme E2 N
, ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
, ubiquitin-conjugating enzyme e2 n
, bendless-like ubiquitin conjugating enzyme
, bendless-like ubiquitin-conjugating enzyme
, ubiquitin carrier protein N
, ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
, ubiquitin-protein ligase N
, yeast UBC13 homolog
, bendless protein