Browse our UBE2N Proteins (UBE2N)

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Ubiquitin-Conjugating Enzyme E2N Proteins (UBE2N)
On are 13 Ubiquitin-Conjugating Enzyme E2N (UBE2N) Proteins from 7 different suppliers available. Additionally we are shipping UBE2N Antibodies (89) and many more products for this protein. A total of 111 UBE2N products are currently listed.
1500026J17Rik, AL022654, BB101821, DDBDRAFT_0169154, DDBDRAFT_0237667, DDB_0169154, DDB_0237667, UBC13, UbcH-ben, UbcH13, UBE2N, wu:fb11b03, wu:fc08b06, zgc:55726
list all proteins Gene Name GeneID UniProt
UBE2N 7334 P61088
Mouse UBE2N UBE2N 93765 P61089
UBE2N 116725 Q9EQX9

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UBE2N Proteins (UBE2N) by Origin

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Top referenced UBE2N Proteins

  1. Human UBE2N Protein expressed in Escherichia coli (E. coli) - ABIN666632 : Yamaguchi, Kim, Sekine, Seino, Osaka, Yamao, Kato: Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. in Journal of biochemistry 1997 (PubMed)
    Show all 2 references for 666632

More Proteins for UBE2N Interaction Partners

Human Ubiquitin-Conjugating Enzyme E2N (UBE2N) interaction partners

  1. The malin (show NHLRC1 Proteins)-laforin (show EPM2A Proteins) complex interacts physically and functionally with the ubiquitin conjugating enzyme E2-N (UBE2N).

  2. Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2 (show UBE2V2 Proteins)) and ring finger protein 4 (RNF4 (show RNF4 Proteins)) together induce an active conformation of the ubiquitin-conjugating enzyme (show Ube2t Proteins) Ubc13-ubiquitin (Ubc13~Ub) thioester.

  3. together with UBE2L3 (show UBE2L3 Proteins) and UBE2D2 (show UBE2D2 Proteins), synergistically contribute to Parkin (show PARK2 Proteins)-mediated mitophagy

  4. MiR (show MLXIP Proteins)-205 inhibits DNA damage repair by targeting ZEB1 and Ubc13.

  5. Ubiquitin-conjugating enzyme (show Ube2t Proteins) complex Uev1A (show UBE2V1 Proteins)-Ubc13 promotes breast cancer metastasis through nuclear factor-small ka, CyrillicB mediated matrix metalloproteinase-1 (show MMP1 Proteins) gene regulation.

  6. Ubc13 was dispensable for transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-induced SMAD (show SMAD1 Proteins) activation but was required for activation of non-SMAD (show SMAD1 Proteins) signaling via TGFbeta (show TGFB1 Proteins)-activating kinase 1 (TAK1 (show MAP3K7 Proteins)) and p38 (show CRK Proteins)

  7. UBE2N inhibition induces neuroblastoma (show ARHGEF16 Proteins) apoptotic cell death via activation of p53 (show TP53 Proteins) and JNK (show MAPK8 Proteins) pathways.

  8. overexpression of hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-4516 downregulates STAT3 (show STAT3 Proteins), p-STAT3 (show STAT3 Proteins), CDK6 (show CDK6 Proteins), and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells.

  9. crystal structure of the Shigella flexneri OspI-Ubc13 complex at 2.3 A resolution; study reveals the molecular basis of Ubc13 deamidation by OspI, as well as a convergence of E2 recognition by bacterial and host proteins

  10. The structure of the Shigella flexneri OspI and human Ubc13 complex revealed that the interacting surfaces between OspI and Ubc13 are a hydrophobic surface and a complementary charged surface.

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2N (UBE2N) interaction partners

  1. GPS2 (show GPS2 Proteins) is required for restricting the activation of TLR and BCR (show BCR Proteins) signaling pathways and the AKT (show AKT1 Proteins)/FOXO1 (show FOXO1 Proteins) pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity

  2. RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.

  3. Overexpressing UBE2N increases the aggregation of mutant huntingtin (show HTT Proteins), and reducing UBE2N attenuates huntingtin (show HTT Proteins) aggregation in cellular and mouse models of Huntington's disease.

  4. STAT3 (show STAT3 Proteins) restrains RANKL (show TNFSF11 Proteins)- and TLR4 (show TLR4 Proteins)-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme (show UBE2L6 Proteins) Ubc13.

  5. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.

  6. These results establish Ubc13 as a crucial regulator of hematopoiesis and suggest a role for Ubc13 in the control of Wnt (show WNT2 Proteins) signaling in hematopoietic stem cells.

  7. Ubc13 is key in the mammalian immune response.

  8. Ubiquitin-conjugating enzyme (show Ube2t Proteins) Ubc13 is a critical component of TNF (show TNF Proteins) receptor-associated factor (TRAF (show TRAF1 Proteins))-mediated inflammatory responses.

  9. modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism

UBE2N Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.

Alternative names and synonyms associated with UBE2N

  • ubiquitin-conjugating enzyme E2N (ube2n)
  • ubiquitin-conjugating enzyme E2Na (ube2na)
  • ubiquitin-conjugating enzyme E2N (UBE2N)
  • ubiquitin-conjugating enzyme E2N (LOC100533434)
  • ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) (UBE2N)
  • hypothetical protein (ube2n)
  • ubiquitin-conjugating enzyme e2 n (ube2n)
  • ubiquitin-conjugating enzyme E2N (Ube2n)
  • 1500026J17Rik protein
  • AL022654 protein
  • BB101821 protein
  • DDBDRAFT_0169154 protein
  • DDBDRAFT_0237667 protein
  • DDB_0169154 protein
  • DDB_0237667 protein
  • UBC13 protein
  • UbcH-ben protein
  • UbcH13 protein
  • UBE2N protein
  • wu:fb11b03 protein
  • wu:fc08b06 protein
  • zgc:55726 protein

Protein level used designations for UBE2N

ubiquitin-conjugating enzyme E2N (UBC13 homolog) , ube13a , ubiquitin-conjugating enzyme E2N , ubiquitin-conjugating enzyme E2 N , ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) , ubiquitin-conjugating enzyme e2 n , bendless-like ubiquitin conjugating enzyme , bendless-like ubiquitin-conjugating enzyme , ubiquitin carrier protein N , ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) , ubiquitin-protein ligase N , yeast UBC13 homolog , bendless protein

380524 Xenopus laevis
406807 Danio rerio
417898 Gallus gallus
611865 Canis lupus familiaris
100533434 Aplysia californica
395006 Xenopus (Silurana) tropicalis
452125 Pan troglodytes
609136 Canis lupus familiaris
8620964 Dictyostelium discoideum AX4
100302360 Ovis aries
100528331 Ictalurus punctatus
7334 Homo sapiens
93765 Mus musculus
116725 Rattus norvegicus
541130 Bos taurus
100174607 Pongo abelii
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