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variants in CD101 (show CD101 Proteins) and UBE2V1 associated with increased risk of sexually acquired HIV-1
Gene and protein expression of UBE2v1, a ubiquitin-conjugating E2-enzyme variant that mediates Lys63-linked ubiquitination, and Lys63-ubiquitinated proteins increased in HK2 (show HK2 Proteins) tubular cells under high glucose; immunohistochemistry on diabtic kidney samples revealed an increase in UBE2v1- and Lys63-ubiquitinated proteins, particularly in kidneys of patients with diabetic nephropathy.
Ubiquitin-conjugating enzyme (show Ube2t Proteins) complex Uev1A-Ubc13 (show UBE2N Proteins) promotes breast cancer metastasis through nuclear factor-small ka, CyrillicB mediated matrix metalloproteinase-1 (show MMP1 Proteins) gene regulation.
Data demonstrate that divergent activities of Ubc13 (show UBE2N Proteins) rely on its pairing with either of two Uevs, Uev1A or Mms2 (show UBE2V2 Proteins).
A structural model for the Ub-hUev1a-hUbc13-Ub tetramer was developed to gain chemical insight into the synthesis of Lys(63)-linked Ubiquitin chains.
These data provide evidence that Uev1A is a critical regulatory component in the NF-kappaB (show NFKB1 Proteins) signaling pathway in response to environmental stresses and identify UEV1A as a potential proto-oncogene (show RAB1A Proteins).
modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA (show PCNA Proteins)- and ATM (show ATM Proteins)/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
ubiquitin-conjugating enzyme E2 variant 1
, DNA-binding protein
, TRAF6-regulated IKK activator 1 beta Uev1A