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anti-Human VAV1 Antibodies:
anti-Rat (Rattus) VAV1 Antibodies:
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Human Polyclonal VAV1 Primary Antibody for IHC - ABIN967242
Amarasinghe, Rosen: Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. in Biochemistry 2005
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Human VAV1 Primary Antibody for WB - ABIN967241
Charvet, Canonigo, Billadeau, Altman: Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. in The Journal of biological chemistry 2005
Show all 4 Pubmed References
Human Monoclonal VAV1 Primary Antibody for FACS, ELISA - ABIN969581
Bertagnolo, Nika, Brugnoli, Bonora, Grassilli, Pinton, Capitani: Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells. in Cell and tissue research 2011
Show all 2 Pubmed References
Human Polyclonal VAV1 Primary Antibody for WB - ABIN362132
Sekine, Ikeda, Tsuji, Yamamoto, Muromoto, Nanbo, Oritani, Yoshimura, Matsuda: Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells. in Journal of immunology (Baltimore, Md. : 1950) 2009
Data show that GEF (show SLC2A4RG Antibodies) Vav1 possesses tumor-suppressor functions in immature T cells.
Polymorphisms of VAV1 gene is associated with Rheumatoid arthritis.
Vav1 expression is increased in esophageal squamous cell carcinoma, indicates poor prognosis, and can serve as a candidate molecular prognostic marker.
TGFbeta (show TGFB1 Antibodies) induced the dissociation of DNMT1 (show DNMT1 Antibodies) from the VAV1 promoter, leading to demethylation and the subsequent ectopic expression of VAV1 in cancer cells via a SMAD4 (show SMAD4 Antibodies)-dependent mechanism
Our results suggest the existence of a Vav1/PU.1/miR (show MLXIP Antibodies)-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia (show PML Antibodies) -derived cells
revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta (show CD3D Antibodies), epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases
Data indicate that only a single mutation in the proto-oncogene (show RAB1A Antibodies) Vav1 enhances tumorigenicity.
These findings establish VAV1 as a critical epigenetically regulated oncogene (show RAB1A Antibodies) with a key role in MBSHH maintenance, and highlight its potential as a validated therapeutic target and prognostic biomarker for the improved therapy of medulloblastoma.
The present study implies that estrogen-estrogen receptor (show ESR1 Antibodies) modulates the transcription and expression of Vav1, which may contribute to the proliferation of cancerous cells.
The role of Vav1 in T leukemia survival by selectively triggering Rac2 (show RAC2 Antibodies)-Akt (show AKT1 Antibodies) axis and elevating the expression of anti-apoptotic Bcl-2 (show BCL2 Antibodies).
this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1 (show SIRT1 Antibodies).
Data show that GEF (show ARHGEF2 Antibodies) Vav1 possesses tumor-suppressor functions in immature T cells.
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 (show GRB2 Antibodies) stability
Vav1 adaptor has a role in the production of inflammatory cytokines by effector T cells and in the susceptibility to neuroinflammation
provide evidence that CD28 (show CD28 Antibodies) and the TCR complex regulate NF-kappaB (show NFKB1 Antibodies) via different signaling modules of GRB-2 (show GRB2 Antibodies)/VAV1 and LAT (show LAT Antibodies)/ADAP (show APP Antibodies) pathways respectively.
Platelet P-Rex and Vav family Rac (show AKT1 Antibodies)-GEFs play important proinflammatory roles in leukocyte recruitment.
The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface.
analyses revealed a SHP2 (show PTPN11 Antibodies)- and Lyn (show LYN Antibodies)-dependent pathway leading to phosphorylation of Vav1, Rac (show AKT1 Antibodies) activation, and F-actin polymerization in SCF (show KITLG Antibodies)-treated BMMCs
Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 (show IL6 Antibodies) production.
Bruton's Tyrosine Kinase (BTK (show BTK Antibodies)) and Vav1 contribute to Dectin1 (show CLEC7A Antibodies)-dependent phagocytosis of Candida albicans in macrophages.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
vav 1 oncogene
, proto-oncogene vav
, vav oncogene