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anti-Human VAV3 Antibodies:
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Human Polyclonal VAV3 Primary Antibody for ELISA, WB - ABIN268548
Movilla, Bustelo: Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. in Molecular and cellular biology 1999
Vav3 is a novel TRAF6 (show TRAF6 Antibodies) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.
this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK (show MAPK1 Antibodies) activation
Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone
Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells
Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK (show EPHB2 Antibodies) pathway
Data show that microRNA miR (show MLXIP Antibodies)-499-5p targeted 3' untranslated regions (3'-UTR (show UTS2R Antibodies)) of vav 3 oncogene protein (VAV3).
Results found that OSR2, VAV3, and PPFIA3 (show PPFIA3 Antibodies) were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (show SYT4 Antibodies), BAG3 (show BAG3 Antibodies), APOA1 (show APOA1 Antibodies), and VAV3, except for VGF (show VGF Antibodies) protein, there was a trend between the expression of these four genes and their protein levels.
VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma.
VAV3 overexpression could be a useful marker for predicting the outcomes of CRC (show CALR Antibodies) patients and that VAV3 targeting represents a potential modality for treating CRC (show CALR Antibodies)
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Platelet P-Rex and Vav (show VAV1 Antibodies) family Rac (show AKT1 Antibodies)-GEFs play important proinflammatory roles in leukocyte recruitment.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin (show INS Antibodies) state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Data demonstrate that the co-expression of the exchange factors Vav2 (show VAV2 Antibodies) and Vav3 is critical for the development of this tumor type.
Vav2 (show VAV2 Antibodies) and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Vav3 collaborates with p190 (show CNTNAP1 Antibodies)-BCR-ABL (show ABL1 Antibodies) in lymphoid progenitor leukemogenesis, proliferation, and survival.
Dectin-1 (show CLEC7A Antibodies) activates the integrin Mac-1 (show ITGAM Antibodies) in neutrophils via Vav1 (show VAV1 Antibodies) and Vav3 signaling to promote Candida albicans clearance.
study discloses an essential and nonredundant role for this Vav (show VAV1 Antibodies) family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates
CD36 (show CD36 Antibodies) contributes to activation of Vav-1 (show VAV1 Antibodies), -2, and -3 in aortae from hyperlipidemic mice
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
vav 3 oncogene
, guanine nucleotide exchange factor VAV3
, vav 3 protein