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Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK (show EPHB2 Proteins) pathway
Data show that microRNA miR (show MLXIP Proteins)-499-5p targeted 3' untranslated regions (3'-UTR) of vav 3 oncogene protein (VAV3).
Results found that OSR2, VAV3, and PPFIA3 (show PPFIA3 Proteins) were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (show SYT4 Proteins), BAG3 (show BAG3 Proteins), APOA1 (show APOA1 Proteins), and VAV3, except for VGF (show VGF Proteins) protein, there was a trend between the expression of these four genes and their protein levels.
VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma.
VAV3 overexpression could be a useful marker for predicting the outcomes of CRC (show CALR Proteins) patients and that VAV3 targeting represents a potential modality for treating CRC (show CALR Proteins)
Inhibition of Vav3 could reverse the drug resistance of gastric cancer cells by downregulating JNK (show MAPK8 Proteins) signaling pathway.
This study proposes VAV3 as a biomarker and a rationale for its use as a signaling target to prevent and/or overcome resistance to endocrine therapy in breast cancer.
A new genome-wide significant association between VAV3 and IgA nephropathy.
Data indicate that Vav3 oncogene (show RAB1A Proteins) protein plays a crucial role in prostate cancer growth and malignant behavior, and could be a potential therapeutic target.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Platelet P-Rex and Vav (show VAV1 Proteins) family Rac (show AKT1 Proteins)-GEFs play important proinflammatory roles in leukocyte recruitment.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin (show INS Proteins) state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type.
Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Vav3 collaborates with p190 (show CNTNAP1 Proteins)-BCR-ABL (show ABL1 Proteins) in lymphoid progenitor leukemogenesis, proliferation, and survival.
Dectin-1 (show CLEC7A Proteins) activates the integrin Mac-1 (show ITGAM Proteins) in neutrophils via Vav1 (show VAV1 Proteins) and Vav3 signaling to promote Candida albicans clearance.
study discloses an essential and nonredundant role for this Vav (show VAV1 Proteins) family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates
CD36 (show CD36 Proteins) contributes to activation of Vav-1 (show VAV1 Proteins), -2, and -3 in aortae from hyperlipidemic mice
Vav3 is a bona fide Ahr (show AHR Proteins) target that is in charge of a limited subset of the developmental and physiological functions controlled by this transcriptional factor.
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
vav 3 oncogene
, guanine nucleotide exchange factor VAV3
, vav 3 protein