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The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA.
DNA2 helicase cleaves G-quadruplex DNA and is required for telomere integrity.DNA2 reduces replication stress at telomeres, thereby preserving genome stability and suppressing cancer development.
Characterization of the endonuclease and ATP-dependent flap (show ALOX5AP ELISA Kits) endo/exonuclease (show EXO1 ELISA Kits) of Dna2.
The suppression of FANCD2 (show FANCD2 ELISA Kits)(-/-) by DNA2 knockdowns suggests that DNA2 and FANCD2 (show FANCD2 ELISA Kits) also have antagonistic roles: in the absence of FANCD2 (show FANCD2 ELISA Kits), DNA2 somehow corrupts repair.
BRCA1 and CtIP (show RBBP8 ELISA Kits) contribute to DSB resection by recruiting Dna2 to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination.
depletion of DNA2 in cells reduces proliferation, addition of estrogen restores proliferation. cells responding to estrogen will proliferate despite impaired in DNA2 activity, potentially promoting genomic instability and triggering cancer development.
EXO1 (show EXO1 ELISA Kits), MRE11 (show MRE11A ELISA Kits), and CtIP (show RBBP8 ELISA Kits) are not involved in the same mechanism of reversed fork processing, whereas human RECQ1 (show RECQL ELISA Kits) limits DNA2 activity by preventing extensive nascent strand degradation.
DNA2 stimulates the helicase activity of BLM.
WRN (show RECQL2 ELISA Kits) and BLM act epistatically with DNA2 to promote the long-range resection of double strand break ends in human cells.
DNA2 interacts with FANCD2 (show FANCD2 ELISA Kits), and cisplatin induces FANCD2 (show FANCD2 ELISA Kits) ubiquitylation even in the absence of DNA2.
These results implicate human DNA2 and the long-patch base-excision repair pathway in the pathogenesis of adult-onset disorders of mtDNA maintenance.
A characterization of the substrate specificities influencing hDna2 binding and cleavage functions and the sequential interaction of hFEN1 and hDna2 on Okazaki fragment intermediates.
analysis of Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication
Dna2 co-localizes in foci with RPA (show RPA1 ELISA Kits) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 ELISA Kits). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 ELISA Kits) and ATM (show ATM ELISA Kits).
Results provide strong evidence that xDNA2 is a major nuclease (show DCLRE1C ELISA Kits) for the resection of DNA ends for homology-dependent DNA double-strand break repair in eukaryotes.
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009
DNA replication ATP-dependent helicase-like homolog
, DNA replication ATP-dependent helicase/nuclease DNA2
, DNA2-like helicase
, DNA replication helicase 2 homolog