You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our anti-Flap Structure-Specific Endonuclease 1 (FEN1) Antibodies

Full name:
anti-Flap Structure-Specific Endonuclease 1 Antibodies (FEN1)
On www.antibodies-online.com are 101 Flap Structure-Specific Endonuclease 1 (FEN1) Antibodies from 21 different suppliers available. Additionally we are shipping Flap Structure-Specific Endonuclease 1 Proteins (55) and Flap Structure-Specific Endonuclease 1 Kits (5) and many more products for this protein. A total of 169 Flap Structure-Specific Endonuclease 1 products are currently listed.
Synonyms:
AW538437, cb879, fen-1, fen1, mf1, rad2, xFEN1a
list all antibodies Gene Name GeneID UniProt
FEN1 14156  
FEN1 2237 P39748
FEN1 84490 Q5XIP6

Show all species

Show all synonyms

All available anti-Flap Structure-Specific Endonuclease 1 Antibodies

Go to our pre-filtered search.

Top referenced anti-Flap Structure-Specific Endonuclease 1 Antibodies

  1. Human Polyclonal FEN1 Primary Antibody for WB - ABIN2801955 : Murray, Tavassoli, al-Harithy, Sheldrick, Lehmann, Carr, Watts: Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. in Molecular and cellular biology 1994 (PubMed)
    Show all 5 references for ABIN2801955

  2. Dog (Canine) Monoclonal FEN1 Primary Antibody for BI, WB - ABIN968459 : Harrington, Lieber: The characterization of a mammalian DNA structure-specific endonuclease. in The EMBO journal 1994 (PubMed)
    Show all 5 references for ABIN968459

  3. Human Polyclonal FEN1 Primary Antibody for EIA, WB - ABIN358036 : Hiraoka, Harrington, Gerhard, Lieber, Hsieh: Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human. in Genomics 1995 (PubMed)
    Show all 3 references for ABIN358036

  4. Human Polyclonal FEN1 Primary Antibody for IF, WB - ABIN389376 : Robins, Pappin, Wood, Lindahl: Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. in The Journal of biological chemistry 1994 (PubMed)
    Show all 3 references for ABIN389376

  5. Human Polyclonal FEN1 Primary Antibody for IF, IHC - ABIN1533720 : Taylor, Noguchi, Totoki, Toyoda, Kuroki, Dewar, Lloyd, Itoh, Takeda, Kim, She, Barlow, Bloom, Bruford, Chang, Cuomo, Eichler, FitzGerald, Jaffe, LaButti, Nicol, Park, Seaman, Sougnez, Yang, Zimmer et al.: Human chromosome 11 DNA sequence and analysis including novel gene identification. ... in Nature 2006 (PubMed)
    Show all 2 references for ABIN1533720

  6. Chicken Polyclonal FEN1 Primary Antibody for WB - ABIN2782483 : Liu, Qiu, Finger, Zheng, Shen: The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations. in Nucleic acids research 2006 (PubMed)

More Antibodies against Flap Structure-Specific Endonuclease 1 Interaction Partners

Arabidopsis thaliana Flap Structure-Specific Endonuclease 1 (FEN1) interaction partners

  1. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.

Mouse (Murine) Flap Structure-Specific Endonuclease 1 (FEN1) interaction partners

  1. WDR4 (show WDR4 Antibodies) regulates FEN1's potential DNA cleavage threat near the site of replication.

  2. The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN (show GEN1 Antibodies) activity, causing aneuploidy-associated cancers.

  3. PARP1 (show PARP1 Antibodies) is required for FEN1 recruitment to DNA repair intermediates in base excision repair.

  4. FFAA Fen1 mutation causes defective Pcna (show PCNA Antibodies) -coordinated Okazaki fragment maturation.

  5. A point mutation in the base excision repair gene flap endonuclease 1 causes a functional deficiency in repairing base damage, such that individuals carrying the mutation or similar mutations are predisposed to chemical-induced cancer development.

  6. FEN1 localization within the mitochondrial compartment of mouse brain tissue

  7. Distinct roles for two Mg2 (show MCOLN1 Antibodies)+ binding sites in the regulation of FEN-1 nuclease (show DCLRE1C Antibodies) activities include enhancement of DNA substrate binding ability and modulation of conformational changes.

  8. FEN1 has roles in DNA repair, as well as in DNA replication

  9. Fen1 is induced independently in mouse embryonic fibroblasts by ultraviolet (UV-C)light

  10. These data demonstrate the importance of the FEN-1/PCNA (show PCNA Antibodies) complex in DNA replication and in the embryonic development of mice.

Human Flap Structure-Specific Endonuclease 1 (FEN1) interaction partners

  1. In this study, we found that cohesion establishment factors, like CHlR1 (show DDX11 Antibodies), cooperatively stimulate endonuclease activity of hFen1 in in vivo mimic condition, including replication protein-A (show GPR153 Antibodies)-coated DNA and high salt.

  2. Under DNA repair conditions, FEN1 efficiently repaired the 5'-phoshotyrosyl bond-containing SSB substrates in the presence of DNA ligase and DNA polymerase (show POLB Antibodies).

  3. WDR4 (show WDR4 Antibodies) regulates FEN1's potential DNA cleavage threat near the site of replication.

  4. Patients with expression of both FEN1 and RAD54B (show RAD54B Antibodies) were prone to have advanced nodal involvement and significantly poor prognosis.

  5. Fen1 significantly stimulated trinucleotide repeats expansion by Pol beta (show POLB Antibodies), but not by the related enzyme Pol lambda (show POLL Antibodies).

  6. YY1 (show YY1 Antibodies) is a transcription repressor of FEN1 regulating FEN1 levels in response to DNA damaging agents.

  7. EXO1 (show EXO1 Antibodies) and FEN1 cleaved the substrate at the boundary between the single-stranded 5' flap (show ALOX5AP Antibodies) and the duplex, whereas FAN1 (show FSCN1 Antibodies) incised it three to four nucleotides in the double-stranded region.

  8. Rate-determining step of FEN1 reflects a kinetic bias against long flaps and trinucleotide repeat sequences.

  9. FEN1 -69G>A and 4150G>T polymorphisms may be associated with cancer susceptibility in Chinese population.

  10. Because FEN1 mutations have been identified in human cancers, our findings raise the possibility that unresolved RNA:DNA hybrid structures contribute to the genomic instability associated with cancer

Flap Structure-Specific Endonuclease 1 (FEN1) Antigen Profile

Antigen Summary

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Alternative names and synonyms associated with Flap Structure-Specific Endonuclease 1 (FEN1)

  • flap structure-specific endonuclease 1 (FEN1) antibody
  • flap endonuclease 1-like (LOC100808044) antibody
  • Flap endonuclease-1 (Bm1_49605) antibody
  • flap endonuclease-1 (AT5G26680) antibody
  • flap structure specific endonuclease 1 (Fen1) antibody
  • flap structure-specific endonuclease 1 (fen1) antibody
  • flap structure-specific endonuclease 1 (fen1-a) antibody
  • flap structure-specific endonuclease 1 (Fen1) antibody
  • nuclease, Rad2 family (FEN1) antibody
  • AW538437 antibody
  • cb879 antibody
  • fen-1 antibody
  • fen1 antibody
  • mf1 antibody
  • rad2 antibody
  • xFEN1a antibody

Protein level used designations for FEN1

flap endonuclease 1 , Flap structure-specific endonuclease 1 , flap structure-specific endonuclease 1 , DNase IV , maturation factor 1 , maturation factor-1 , 5' nuclease xFEN1a , FEN-1-A , flap endonuclease 1-A , flap structure-specific endonuclease 1-A , xFEN-1a , FEN-1

GENE ID SPECIES
100059838 Equus caballus
100808044 Glycine max
6104806 Brugia malayi
832721 Arabidopsis thaliana
14156 Mus musculus
2237 Homo sapiens
386707 Danio rerio
394303 Xenopus laevis
769677 Gallus gallus
476063 Canis lupus familiaris
616242 Bos taurus
84490 Rattus norvegicus
100307042 Ovis aries
5721250 Chlamydomonas reinhardtii
Selected quality suppliers for anti-Flap Structure-Specific Endonuclease 1 (FEN1) Antibodies
Did you look for something else?