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Findings suggest the oncogenic potential of H2A.Z.1 in liver tumorigenesis and that it plays established role in accelerating cell cycle transition and EMT (show ITK Proteins) during hepatocarcinogenesis.
Crystal structure results show that the flexible character of the H2A.Z L1 loop plays an essential role in forming the stable heterotypic H2A.Z/H2A nucleosome.
Monoubiquitination of histone H2B blocks eviction of histone variant H2A.Z from inducible enhancers.
Thus, PWWP2A is a novel H2A.Z-specific multivalent chromatin binder providing a surprising link between H2A.Z, chromosome segregation, and organ development.
SMYD3 (show SMYD3 Proteins)-mediated H2A.Z.1K101 dimethylation activates cyclin A1 (show CCNA1 Proteins) expression and contributes to driving the proliferation of breast cancer cells.
Results suggest that the N-terminal tail of H2A.Z makes distinctively different contributions to epigenetic events.
the H2AFZ gene may confer a risk for schizophrenia and contribute to the impairment of executive function in Han Chinese patients with schizophrenia.
The 2.7-A-resolution crystal structure of the human YL1 (show VPS72 Proteins)-H2A.Z-H2B complex shows that YL1 (show VPS72 Proteins) binding, similarly to ANP32E (show ANP32E Proteins) binding, triggers an extension of the H2A.Z alphaC helix.
H2A.Z removal from chromatin is the primary function of INO80 and ANP32E (show ANP32E Proteins) in promoting homologous recombination.
Results demonstrated male-selective association of the H2AFZ gene with schizophrenia, and that modification of the H2AFZ signaling pathway warrants further study in terms of the pathophysiology of schizophrenia
This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 (show BRD2 Proteins) to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs.
Embryonic stem cell BAF (show BANF1 Proteins) is required for normal H2A.Z localization in these cells, suggesting BAF (show BANF1 Proteins) either stabilizes H2A.Z containing nucleosomes or promotes subnucleosome to nucleosome conversion by facilitating H2A.Z deposition.
Study mapped H2A.Z genome-wide in embryonic stem cells and neural progenitors; H2A.Z is deposited at promoters and enhancers, and correlates strongly with H3K4 methylation. H2A.Z is present at poised promoters with bivalent chromatin and at active promoters with H3K4 methylation, but is absent from stably repressed promoters that are enriched for H3K27 trimethylation.
our work suggests that the divergent residues in the H2A.Z acidic patch comprise a unique domain that couples control of chromatin dynamics to the regulation of developmental gene expression patterns during lineage commitment.
Data propose that H2A.Z mediates such contrasting activities by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive.
The variant histone H2A.Z and the winged helix transcription factor (show FOXC1 Proteins) Foxa2 (show FOXA2 Proteins) both act to regulate nucleosome depletion and gene activation, thus promoting embryonic stem cell differentiation, whereas DNA methylation (show HELLS Proteins) promotes nucleosome occupation and suppresses gene expression.
incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma (show PPARG Proteins) target genes by p400 (show ITPR1 Proteins)/Brd8 (show BRD8 Proteins) is essential to allow fat cell differentiation
In mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS (show RPL38 Proteins) becoming heterotypic (H2A.Z-H2A).
It was shown that Ring1B (show RNF2 Proteins) interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed (show EED Proteins), Ring1B (show RNF2 Proteins) and CpG islands in chromatin, H2A.Z still blanketed polycomb (show CBX2 Proteins) target loci in the absence of Suz12, Eed (show EED Proteins), or Ring1B (show RNF2 Proteins).
Studies indicate that the unique chromatin landscape also includes a second histone variant, H2A.Z.
Depletion of H2A.Z by RNA interference perturbs Xenopus laevis development at gastrulation leading to embryos with malformed, shortened trunks.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
, histone H2A.Z
, H2A histone family, member Z
, H2A histone family member V
, H2A histone family, member V
, histone H2A.V
, histone H2A.Z-like
, histone H2A.Zl2
, histone H2AF