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nonphosphorylated p68 (show ANXA6 ELISA Kits) inhibited the stimulation of pol-alpha activity by hyperphosphorylated retinoblastoma protein, suggesting that p68 (show ANXA6 ELISA Kits) might impede the association of ppRb with p180 (show ITGAL ELISA Kits) [Dna polymerase alpha p68 (show ANXA6 ELISA Kits)]
STN1 (show STON1 ELISA Kits)-POLA2 interaction provides a basis for primase-polymerase alpha stimulation by human STN1 (show STON1 ELISA Kits).
our findings showed that knockdown of POLA2 increases gemcitabine resistance in human lung cancer cells. We propose that POLA2 may play a role in gemcitabine sensitivity and can be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis.
POLA2+1747 GG/GA may be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis
Findings indicate that tethering of primase to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells.
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity).
polymerase (DNA directed), alpha 2 (70kD subunit)
, DNA polymerase alpha subunit B
, polymerase (DNA-directed), alpha (70kD)
, DNA-directed DNA polymerase alpha 2
, DNA polymerase alpha subunit B-like
, DNA polymerase alpha 2, 68 kDa
, DNA polymerase alpha 70 kDa subunit
, DNA polymerase alpha subunit II
, DNA polymerase subunit II