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anti-Human POLD2 Antibodies:
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Human Polyclonal POLD2 Primary Antibody for WB - ABIN1881666
Perez, Leon, Lee: Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta. in Biochimica et biophysica acta 2000
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Human Polyclonal POLD2 Primary Antibody for WB - ABIN1944887
He, Tan, Downey, So: A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 5 Pubmed References
The proofreading activity of DNA polymerase delta (show POLD1 Antibodies) plays a role in shunting DNA mismatch repair to an EXO1 (show EXO1 Antibodies)-dependent excision pathway as opposed to directly participating in gap formation via its 3'-5' exonuclease (show EXOSC10 Antibodies) activity.
Inhibition of DNA polymerases a, delra and e by AFP (show AFP Antibodies) promoter-driven artificial microRNAs may lead to effective growth arrest of AFP (show AFP Antibodies)-positive HCC (show FAM126A Antibodies) cells,as novel strategy for gene therapy
The results show that the FF483-484 amino acids in the human Poleta (designated F1 motif) are necessary for the interaction of this polymerase with POLD2, the B subunit of the replicative DNA polymerase delta (show POLD1 Antibodies), both in vitro and in vivo.
DNA polymerase delta catalytic subunit (show POLD1 Antibodies) p125 (show XPC Antibodies) induced by mutant type p53 (show TP53 Antibodies) is associated with hepatocellular carcinoma invasion.
Results suggest that POLD2 and KSP37 might be potential prognostic biomarkers.
the interaction of PCNA (show PCNA Antibodies) with DNA polymerase delta (show POLD1 Antibodies) is mediated through the small subunit of the enzyme
The association of PDIP38 (show POLDIP2 Antibodies) with pol delta (show POLD1 Antibodies) was shown to occur in calf thymus tissue and mammalian cell extracts by GST (show SLCO6A1 Antibodies)-PDIP38 (show POLDIP2 Antibodies) pull-down and coimmunoprecipitation experiments.
As a first step towards understanding the functional importance of their regulatory subunit interactions, the three-dimensional structure of the p50 (show CD40 Antibodies)-p66 (show POLD3 Antibodies) heterodimer of human Pol delta (show POLD1 Antibodies) has been solved using X-ray crystallography.
the crystal structure of p50 (show CD40 Antibodies)*p66 (show POLD3 Antibodies)(N) complex featuring oligonucleotide binding and phosphodiesterase domains in p50 (show CD40 Antibodies)
A direct interaction between Pold2 and PIAS2 (show PIAS2 Antibodies) was confirmed by direct yeast two-hybrid.
The association of PDIP38 (show POLDIP2 Antibodies) with pol delta (show POLD1 Antibodies) was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 (show POLDIP2 Antibodies) pull-down and coimmunoprecipitation experiments.
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
DNA polymerase delta subunit 2
, DNA polymerase delta subunit p50
, Pol delta B subunit (p50)
, polymerase (DNA directed), delta 2, regulatory subunit 50kDa
, DNA-directed DNA polymerase delta 2
, polymerase (DNA directed), delta 2, regulatory subunit