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Browse our anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antibodies

Full name:
anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit Antibodies (POLD3)
On www.antibodies-online.com are 42 Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antibodies from 11 different suppliers available. Additionally we are shipping Polymerase (DNA-Directed), delta 3, Accessory Subunit Proteins (4) and many more products for this protein. A total of 49 Polymerase (DNA-Directed), delta 3, Accessory Subunit products are currently listed.
Synonyms:
2410142G14Rik, C85233, P66, P68, zgc:136471
list all antibodies Gene Name GeneID UniProt
POLD3 10714 Q15054
POLD3 67967  
POLD3 293144  

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All available anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit Antibodies

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Top referenced anti-Polymerase (DNA-Directed), delta 3, Accessory Subunit Antibodies

  1. Human Polyclonal POLD3 Primary Antibody for EIA, WB - ABIN954235 : Baranovskiy, Babayeva, Liston, Rogozin, Koonin, Pavlov, Vassylyev, Tahirov: X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
    Show all 4 references for ABIN954235

  2. Human Monoclonal POLD3 Primary Antibody for IP, WB - ABIN2451953 : Johnson, ODonnell: Cellular DNA replicases: components and dynamics at the replication fork. in Annual review of biochemistry 2005 (PubMed)
    Show all 3 references for ABIN2451953

  3. Human Monoclonal POLD3 Primary Antibody for IF, ELISA - ABIN564666 : Bursomanno, Beli, Khan, Minocherhomji, Wagner, Bekker-Jensen, Mailand, Choudhary, Hickson, Liu: Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. in DNA repair 2014 (PubMed)

More Antibodies against Polymerase (DNA-Directed), delta 3, Accessory Subunit Interaction Partners

Human Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) interaction partners

  1. Data suggest that relatively high affinity binding of PolD3-RIR (show APBB1 Antibodies) motif to Rev1 (show REV1 Antibodies)-C-terminal domain displaces subunits from PolN, Pol-iota (show POLM Antibodies), or PolK (show PAPD7 Antibodies) from Rev1 (show REV1 Antibodies) complex and promotes formation of Rev1 (show REV1 Antibodies)/PolZ4 assembly with PCNA (show PCNA Antibodies) for translesion DNA replication.

  2. POLD3 is SUMOylated by SUMO2 (show SUMO2 Antibodies) in response to replication stress and could play an important role in the regulation of cellular response to DNA replication stress.

  3. Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.

  4. In a cyclin E (show CCNE1 Antibodies) overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis.

  5. Pol delta3 is the predominant form of Pol delta (show POLD1 Antibodies) at sites of UV damage as a result of p12 (show POLE4 Antibodies) degradation; results show that Pol delta (show POLD1 Antibodies) at the DNA damage site is the Pol delta (show POLD1 Antibodies) trimer lacking p12 (show POLE4 Antibodies) regardless of the cell cycle phase

  6. We identified three new CRC (show CALR Antibodies) risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2 (show SHROOM2 Antibodies); P = 7.30 x 10(-10)).

  7. Serine-458, located in the proliferating cell nuclear antigen (PCNA (show PCNA Antibodies))-interacting motif of Poldelta(p68 (show ANXA6 Antibodies)), is a phosphorylation site for protein kinase A (PKA); p68 (show ANXA6 Antibodies) mutation results in decreased p68 (show ANXA6 Antibodies) affinity for PCNA (show PCNA Antibodies) as well as processivity of Poldelta.

  8. show that there is a direct interaction between p66 and PCNA (show PCNA Antibodies) in living cells during DNA replication. The dominant negative effect upon growth resulting from expression of p66 sub-domains confirms that the p66-PCNA (show PCNA Antibodies) interaction is essential in vivo.

  9. POLD3, plays a crucial role in the efficient recycling of PCNA (show PCNA Antibodies) during dissociation-association cycles of pol delta (show POLD1 Antibodies) during elongation phase of DNA replication.

  10. Taken together, the results provide evidence that concurrent phosphorylation events in p66 may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle.

Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antigen Profile

Antigen Summary

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3)

  • polymerase (DNA-directed), delta 3, accessory subunit (pold3) antibody
  • polymerase (DNA-directed), delta 3, accessory subunit (LOC100221313) antibody
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3) antibody
  • polymerase (DNA-directed), delta 3, accessory subunit (Pold3) antibody
  • 2410142G14Rik antibody
  • C85233 antibody
  • P66 antibody
  • P68 antibody
  • zgc:136471 antibody

Protein level used designations for POLD3

DNA-directed DNA polymerase delta 3 , DNA polymerase delta p66 subunit , DNA polymerase delta subunit 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA polymerase delta subunit 3-like , DNA polymerase delta subunit p66 , Pol delta C subunit (p66) , GC12 , polymerase (DNA directed), delta 3

GENE ID SPECIES
398707 Xenopus laevis
692256 Danio rerio
100221313 Taeniopygia guttata
100357626 Oryctolagus cuniculus
100403947 Callithrix jacchus
100435558 Pongo abelii
100471417 Ailuropoda melanoleuca
100602450 Nomascus leucogenys
10714 Homo sapiens
67967 Mus musculus
293144 Rattus norvegicus
537616 Bos taurus
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