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Browse our Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) ELISA Kits

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Polymerase (DNA-Directed), delta 3, Accessory Subunit ELISA Kits (POLD3)
On www.antibodies-online.com are 0 Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) ELISA Kits from different suppliers available. Additionally we are shipping Polymerase (DNA-Directed), delta 3, Accessory Subunit Antibodies (42) and Polymerase (DNA-Directed), delta 3, Accessory Subunit Proteins (4) and many more products for this protein. A total of 49 Polymerase (DNA-Directed), delta 3, Accessory Subunit products are currently listed.
Synonyms:
2410142G14Rik, C85233, P66, P68, zgc:136471
list all ELISA KIts Gene Name GeneID UniProt
Human POLD3 POLD3 10714 Q15054
Mouse POLD3 POLD3 67967  
Rat POLD3 POLD3 293144  

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More ELISA Kits for Polymerase (DNA-Directed), delta 3, Accessory Subunit Interaction Partners

Human Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) interaction partners

  1. Data suggest that relatively high affinity binding of PolD3-RIR (show APBB1 ELISA Kits) motif to Rev1 (show REV1 ELISA Kits)-C-terminal domain displaces subunits from PolN, Pol-iota, or PolK from Rev1 (show REV1 ELISA Kits) complex and promotes formation of Rev1 (show REV1 ELISA Kits)/PolZ4 assembly with PCNA (show PCNA ELISA Kits) for translesion DNA replication.

  2. POLD3 is SUMOylated by SUMO2 (show SUMO2 ELISA Kits) in response to replication stress and could play an important role in the regulation of cellular response to DNA replication stress.

  3. Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.

  4. In a cyclin E (show CCNE1 ELISA Kits) overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis.

  5. Pol delta3 is the predominant form of Pol delta (show POLD1 ELISA Kits) at sites of UV damage as a result of p12 (show POLE4 ELISA Kits) degradation; results show that Pol delta (show POLD1 ELISA Kits) at the DNA damage site is the Pol delta (show POLD1 ELISA Kits) trimer lacking p12 (show POLE4 ELISA Kits) regardless of the cell cycle phase

  6. We identified three new CRC (show CALR ELISA Kits) risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2 (show SHROOM2 ELISA Kits); P = 7.30 x 10(-10)).

  7. Serine-458, located in the proliferating cell nuclear antigen (PCNA (show PCNA ELISA Kits))-interacting motif of Poldelta(p68 (show ANXA6 ELISA Kits)), is a phosphorylation site for protein kinase A (PKA); p68 (show ANXA6 ELISA Kits) mutation results in decreased p68 (show ANXA6 ELISA Kits) affinity for PCNA (show PCNA ELISA Kits) as well as processivity of Poldelta.

  8. show that there is a direct interaction between p66 and PCNA (show PCNA ELISA Kits) in living cells during DNA replication. The dominant negative effect upon growth resulting from expression of p66 sub-domains confirms that the p66-PCNA (show PCNA ELISA Kits) interaction is essential in vivo.

  9. POLD3, plays a crucial role in the efficient recycling of PCNA (show PCNA ELISA Kits) during dissociation-association cycles of pol delta (show POLD1 ELISA Kits) during elongation phase of DNA replication.

  10. Taken together, the results provide evidence that concurrent phosphorylation events in p66 may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle.

Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Antigen Profile

Antigen Summary

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3)

  • polymerase (DNA-directed), delta 3, accessory subunit (pold3) Elisa Kit
  • polymerase (DNA-directed), delta 3, accessory subunit (LOC100221313) Elisa Kit
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3) Elisa Kit
  • polymerase (DNA-directed), delta 3, accessory subunit (Pold3) Elisa Kit
  • 2410142G14Rik Elisa Kit
  • C85233 Elisa Kit
  • P66 Elisa Kit
  • P68 Elisa Kit
  • zgc:136471 Elisa Kit

Protein level used designations for POLD3

DNA-directed DNA polymerase delta 3 , DNA polymerase delta p66 subunit , DNA polymerase delta subunit 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA polymerase delta subunit 3-like , DNA polymerase delta subunit p66 , Pol delta C subunit (p66) , GC12 , polymerase (DNA directed), delta 3

GENE ID SPECIES
398707 Xenopus laevis
692256 Danio rerio
100221313 Taeniopygia guttata
100357626 Oryctolagus cuniculus
100403947 Callithrix jacchus
100435558 Pongo abelii
100471417 Ailuropoda melanoleuca
100602450 Nomascus leucogenys
10714 Homo sapiens
67967 Mus musculus
293144 Rattus norvegicus
537616 Bos taurus
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