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Browse our Polymerase (DNA-Directed), delta 3, Accessory Subunit Proteins (POLD3)

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Polymerase (DNA-Directed), delta 3, Accessory Subunit Proteins (POLD3)
On www.antibodies-online.com are 4 Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Proteins from 3 different suppliers available. Additionally we are shipping Polymerase (DNA-Directed), delta 3, Accessory Subunit Antibodies (41) and many more products for this protein. A total of 48 Polymerase (DNA-Directed), delta 3, Accessory Subunit products are currently listed.
Synonyms:
2410142G14Rik, C85233, P66, P68, zgc:136471
list all proteins Gene Name GeneID UniProt
POLD3 10714 Q15054
POLD3 67967  
Rat POLD3 POLD3 293144  

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Polymerase (DNA-Directed), delta 3, Accessory Subunit Proteins (POLD3) by Origin

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More Proteins for Polymerase (DNA-Directed), delta 3, Accessory Subunit Interaction Partners

Human Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) interaction partners

  1. Data suggest that relatively high affinity binding of PolD3-RIR (show APBB1 Proteins) motif to Rev1 (show REV1 Proteins)-C-terminal domain displaces subunits from PolN, Pol-iota (show POLM Proteins), or PolK (show PAPD7 Proteins) from Rev1 (show REV1 Proteins) complex and promotes formation of Rev1 (show REV1 Proteins)/PolZ4 assembly with PCNA (show PCNA Proteins) for translesion DNA replication.

  2. POLD3 is SUMOylated by SUMO2 (show SUMO2 Proteins) in response to replication stress and could play an important role in the regulation of cellular response to DNA replication stress.

  3. Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.

  4. In a cyclin E (show CCNE1 Proteins) overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis.

  5. Pol delta3 is the predominant form of Pol delta (show POLD1 Proteins) at sites of UV damage as a result of p12 (show POLE4 Proteins) degradation; results show that Pol delta (show POLD1 Proteins) at the DNA damage site is the Pol delta (show POLD1 Proteins) trimer lacking p12 (show POLE4 Proteins) regardless of the cell cycle phase

  6. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)).

  7. Serine-458, located in the proliferating cell nuclear antigen (PCNA (show PCNA Proteins))-interacting motif of Poldelta(p68 (show ANXA6 Proteins)), is a phosphorylation site for protein kinase A (PKA); p68 (show ANXA6 Proteins) mutation results in decreased p68 (show ANXA6 Proteins) affinity for PCNA (show PCNA Proteins) as well as processivity of Poldelta.

  8. show that there is a direct interaction between p66 and PCNA (show PCNA Proteins) in living cells during DNA replication. The dominant negative effect upon growth resulting from expression of p66 sub-domains confirms that the p66-PCNA (show PCNA Proteins) interaction is essential in vivo.

  9. POLD3, plays a crucial role in the efficient recycling of PCNA (show PCNA Proteins) during dissociation-association cycles of pol delta (show POLD1 Proteins) during elongation phase of DNA replication.

  10. Taken together, the results provide evidence that concurrent phosphorylation events in p66 may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle.

Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3) Protein Profile

Protein Summary

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with Polymerase (DNA-Directed), delta 3, Accessory Subunit (POLD3)

  • polymerase (DNA-directed), delta 3, accessory subunit (pold3)
  • polymerase (DNA-directed), delta 3, accessory subunit (LOC100221313)
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3)
  • polymerase (DNA-directed), delta 3, accessory subunit (Pold3)
  • 2410142G14Rik protein
  • C85233 protein
  • P66 protein
  • P68 protein
  • zgc:136471 protein

Protein level used designations for POLD3

DNA-directed DNA polymerase delta 3 , DNA polymerase delta p66 subunit , DNA polymerase delta subunit 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA polymerase delta subunit 3-like , DNA polymerase delta subunit p66 , Pol delta C subunit (p66) , GC12 , polymerase (DNA directed), delta 3

GENE ID SPECIES
398707 Xenopus laevis
692256 Danio rerio
100221313 Taeniopygia guttata
100357626 Oryctolagus cuniculus
100403947 Callithrix jacchus
100435558 Pongo abelii
100471417 Ailuropoda melanoleuca
100602450 Nomascus leucogenys
10714 Homo sapiens
67967 Mus musculus
293144 Rattus norvegicus
537616 Bos taurus
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