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The identification of RNF8 (show RNF8 ELISA Kits) allows new insights into the integration of the control of p12 (show CDK2AP1 ELISA Kits) degradation by different DNA damage signaling pathways.
the p12 (show POLE4 ELISA Kits)/Pol delta (show POLD1 ELISA Kits) is a target as a nuclear substrate of mu-calpain (show CAPNL1 ELISA Kits) in a calcium-triggered apoptosis and appears to be a potential marker in the study of the chemotherapy of cancer therapies.
A parallel study of Pol delta4 and Pol delta3 in Okazaki fragment processing provides evidence for a role of Pol delta3 in DNA replication
Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.
ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.
Data indicate that CRL4(Cdt2) regulates the degradation of the p12 subunit of Pol delta4.
The identification of RNF8 (show RNF8 ELISA Kits) allows new insights into the integration of the control of p12 (show POLE4 ELISA Kits) degradation by different DNA damage signaling pathways.
Low POLD4 (show POLDIP2 ELISA Kits) is associated with lung cancer.
these results indicate that POLD4 (show POLDIP2 ELISA Kits) is required for the in vitro pol delta (show POLD1 ELISA Kits) activity, and that it functions in cell proliferation and maintenance of genomic stability of human cells.
pol delta (show POLD1 ELISA Kits) interacts with PCNA (show PCNA ELISA Kits) via at least two of its subunits, and p12 (show POLE4 ELISA Kits) could play a role in stabilizing the overall pol delta (show POLD1 ELISA Kits)-PCNA (show PCNA ELISA Kits) complex as well as pol delta (show POLD1 ELISA Kits) itself
The DNA polymerase delta (show POLD1 ELISA Kits) enzyme, as well as the isolated p12 (show POLE4 ELISA Kits) subunit, stimulates the DNA helicase activity of Bloom's syndrome helicase.
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DNA polymerase delta subunit 4
, DNA polymerase delta subunit p12
, DNA-directed DNA polymerase delta 4
, DNA polymerase delta smallest subunit p12