Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human ATF4 Antibodies:
anti-Mouse (Murine) ATF4 Antibodies:
anti-Rat (Rattus) ATF4 Antibodies:
Go to our pre-filtered search.
Human Monoclonal ATF4 Primary Antibody for IF, ELISA - ABIN559979
Meister, Frey, Lang, Gaipl, Schett, Schlötzer-Schrehardt, Voll: Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. in Neoplasia (New York, N.Y.) 2010
Show all 5 Pubmed References
Mouse (Murine) Polyclonal ATF4 Primary Antibody for IHC, WB - ABIN2779918
Smith, Schmechel, Raghavan, Abelson, Reilly, Katze, Kaufman, Bohjanen, Schiff: Reovirus induces and benefits from an integrated cellular stress response. in Journal of virology 2006
Show all 5 Pubmed References
Human Polyclonal ATF4 Primary Antibody for IF (p), IHC (p) - ABIN687862
Jiang, Ren, Jiang, Wang, Zhang, Yin, Wang, Qi, Wang, Feng: Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. in Neuroscience 2014
Show all 3 Pubmed References
Human Polyclonal ATF4 Primary Antibody for IF (p), IHC (p) - ABIN756172
Jiang, Yun, Shi, Niu, Gao, Xie, Yu: Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress. in American journal of physiology. Cell physiology 2016
Show all 2 Pubmed References
Human Polyclonal ATF4 Primary Antibody for ELISA, WB - ABIN257681
Tsujimoto, Nyunoya, Morita, Sato, Shimotohno: Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. in Journal of virology 1991
Show all 2 Pubmed References
Human Polyclonal ATF4 Primary Antibody for ICC, IF - ABIN4282025
Oh, Pan, Yalcin, Zhang, Guilarte, Hotamisligil, Christiani, Lu: Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. in The Journal of biological chemistry 2012
Human Polyclonal ATF4 Primary Antibody for IHC - ABIN965616
Yang, Matsuda, Bialek, Jacquot, Masuoka, Schinke, Li, Brancorsini, Sassone-Corsi, Townes, Hanauer, Karsenty: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. in Cell 2004
Cow (Bovine) Polyclonal ATF4 Primary Antibody for WB - ABIN2780377
Kalinec, Thein, Parsa, Yorgason, Luxford, Urrutia, Kalinec: Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. in Hearing research 2014
Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.
Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).
Expression of either dominant-negative or constitutively active mutants of Nrf2 (show GABPA Antibodies), ATF4, or c-Jun (show JUN Antibodies) confirmed that distinct transcription units are regulated by these transcription factors.
ATF4 contributes to tumor growth of endometrial cancer (EC) by promoting CCL2 (show CCL2 Antibodies) and subsequent recruitment of macrophage, and ATF4/CCL2 (show CCL2 Antibodies) axis might be a potential therapeutic target for EC.
ATF4 expression fosters the malignancy of primary brain tumors and increases proliferation and tumor angiogenesis; experiments revealed that ATF4-dependent tumor promoting effects are mediated by transcriptional targeting the glutamate (show GRIN1 Antibodies) antiporter xCT (show SLC7A11 Antibodies)
The PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies)-ATF4-CHOP (show DDIT3 Antibodies) signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
ATF4 pathway is activated in vivo upon mitochondrial stress.
a shortage of tryptophan caused by expression of indoleamine 2,3-dioxygenase (IDO (show IDO1 Antibodies)) and tryptophan 2,3-dioxygenase (TDO (show TDO2 Antibodies)) resulted in ATF4-dependent upregulation of several amino acid transporters.
SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK (show EIF2AK3 Antibodies)-ATF4 pathway.
There was decreased or loss of ATF4 in 52% of medullary thyroid cancer (MTC) (show RET Antibodies)tumors (n = 39) compared with normal thyroid follicle cells. A negative correlation was observed between RET and ATF4 protein levels in MTC tumors.
hypoxia-induced ATF4 expression may promote progression of proliferating infantile hemangioma through macrophage colony-stimulating factor (show CSF2 Antibodies) induced M2-polarized macrophages infiltration.
overexpression of eIF5 (show EIF5 Antibodies) and 5MP induces translation of ATF4.
MIF-2 (show HSPA5 Antibodies)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI (show SLPI Antibodies)- and ATF4-dependent mechanisms.
ATF4 has a role in gene expression during basal conditions, with 385 genes altered by the loss of ATF4 in the absence of apparent stress. Deletion of ATF4 alters genes that are required for the conversion of cholesterol to bile acid (CYP7A1 (show CYP7A1 Antibodies)), esterification of cholesterol (SOAT2 (show SOAT2 Antibodies)), and transport from the hepatocyte (ABCA1 (show ABCA1 Antibodies)); when ATF4 loss is coupled with ER stress, results in increase in free cholesterol within hepatocyte
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (show EIF2A Antibodies) phosphorylation by inhibiting PPP1CA (show PPP1CA Antibodies) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 expression. (eIF2a (show EIF2A Antibodies) = eukaryotic initiation factor-2alpha (show EIF2S1 Antibodies); PPP1CA (show PPP1CA Antibodies) = protein phosphatase 1 catalytic subunit alpha; Atf4 = activating transcription factor 4)
Results identify the beneficial role of hypothalamic ATF4/ATG5 axis in the regulation of energy expenditure, obesity, and obesity-related metabolic disorders.
SLC30A10 (show SLC30A10 Antibodies) has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK (show EIF2AK3 Antibodies)-ATF4 pathway.
ER stress-induced increase in ATF4 and CHOP (show DDIT3 Antibodies) expression is initiated by an increase in Atf4 and Chop (show DDIT3 Antibodies) mRNA, which is also dependent upon eIF2alpha (show EIF2A Antibodies) phosphorylation.
Augmented ATF4 signals during retinal degeneration plays a cytotoxic role by triggering photoreceptor cell death.
ATF4 might inhibit the transcription of Srebp1c (show SREBF1 Antibodies) through TRB3 (show TRIB3 Antibodies), which is repressed by IBMX and DEX during early adipogenesis
ATF4 activates a negative-feedback loop, leading to the downregulation of RET (show RET Antibodies) expression while upregulating expression of proapoptotic genes.
expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs
Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Antibodies) and CREB3 (show CREB3 Antibodies) mRNA were ubiquitously detected in all examined tissues.
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
cyclic AMP-dependent transcription factor ATF-4
, activating transcription factor 4 (tax-responsive enhancer element B67)
, cAMP-dependent transcription factor ATF-4
, activating transcription factor 4C
, activating transcription factor 4
, DNA-binding protein TAXREB67
, cAMP response element-binding protein 2
, cAMP-responsive element-binding protein 2
, cyclic AMP-responsive element-binding protein 2
, tax-responsive enhancer element B67
, tax-responsive enhancer element-binding protein 67
, c/EBP-related ATF
, tax-responsive enhancer element-binding protein 67 homolog
, taxREB67 homolog
, activating transcription factor ATF-4