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study provides evidence that muscle beta-catenin is crucial for maintenance of resting membrane potential(RMP)of skeletal muscle cells; muscle cells lacking beta-catenin show decreased expression of alpha2 subunit of Na,K-ATPase, a probable mechanism by which beta-catenin regulates RMP and affects normal function of skeletal muscle
Atp1a2 has a more prominent role (vs. Atp1a1 (show ATP1A1 Proteins)) in modulating cardiac myocyte sarcoplasmic reticulum Ca(2 (show CA2 Proteins)+) release.
The ouabain-binding site of either the alpha1 or alpha2 Na,K-ATPase (show ATP1A1 Proteins) subunit does not play an essential role in the development of DOCA-salt hypertension in a mouse model
Central sodium chloride causes hypertension in mice. The blood pressure response is mediated by the ouabain-like substance in the brain, specifically by its binding to the alpha(2)-isoform of the Na,K-ATPase (show ATP1A1 Proteins).
Atp1a2 expression in heart and vascular smooth muscle is not essential for regulation of basal systolic blood pressure.
Ion channel NKCC1 (show SLC12A2 Proteins) and alpha2 Na, K-ATPase (show ATP1A1 Proteins) played important roles in the inner ear potassium recycling.
Both protein and mRNA expression of alpha1 and alpha2 isoforms of Na,K-ATPase (show ATP1A1 Proteins) and NKCC1 (show SLC12A2 Proteins) in the lateral wall were dramatically reduced following a long-term deafening
The cardiotonic steroid-binding site of the alpha2 Na,K-ATPase (show ATP1A1 Proteins) plays a role in maintaining normal SBP during pregnancy
The Na,K-ATPase alpha(2) subunit is expressed during development when the t-tubules form. These results suggest that the alpha(2) isoform may serve, in part, a physiological role in the muscle t-tubules.
Na,K-ATPase (show ATP1A1 Proteins) alpha2 isoform could be important in the modulation of neuronal activity in the neonate
On the other hand, the presence of KCNK18 (show KCNK18 Proteins) mutation indicated another FHM (show CACNA1A Proteins) subtype.
A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine
Report tumor cell sensitivity to cardiac glycosides depends on pattern of expression of alpha1-, alpha2-, or alpha3-isoforms of Na-K-ATPase (show ATP1A1 Proteins).
Data indicate that a second-site mutation distant from Na+ site III increases Na+ affinity, Na(+),K(+)-ATPase (show ATP1A1 Proteins) activity, and cellular K+ uptake in mutants with the replacement of the aspartate.
genome-wide linkage analysis of the migraine phenotype in 38 families with Rolandic epilepsy; evidence found of linkage to migraine at chromosome 17q12-22 and suggestive evidence at 1q23.1-23.2, centering over the FHM2 locus
Three patients with a proven mutation in the ATP1A2 gene clinically presented without hemiparesis.
mutations in the ATP1A2 gene might contribute to pulmonary arterial remodelling and pulmonary arterial hypertension
Identification of a novel heterozygous mutation in the ATP1A2 gene (c.1766T>C, Ile589Thr) causing atypical alternating hemiplegia of childhood in a Saudi consanguineous family
In this family, benign familial infantile seizures (BFIS) are caused by a PRRT2 (show PRRT2 Proteins) mutation and hemiplegic migraine by p.Arg689Gln ATPase ATP1A2 mutation.
The present study provides further evidence on the involvement of ATP1A2 mutations in both migraine and epilepsy, underlying the relevance of genetic analysis in families with a comorbidity of both disorders.
biochemical and biophysical characteristics of the alpha(2)beta(1) isozyme of Na(+)/K(+)-ATPase (show ATP1A1 Proteins) from caveolae vesicles of pulmonary smooth muscle plasma membrane were studied during solubilization and purification
Na,K-ATPase (show ATP1A1 Proteins) alpha2 and Ncx4a regulate left-right patterning by modulating intracellular calcium levels in Kupffer's vesicle and by influencing cilia function
Study reports the cloning and expression of Na, K-ATPase (show ATP1A1 Proteins) alpha2 (atp1a2) and alpha3 (atp1a3 (show ATP1A3 Proteins)) subunits during Xenopus development and compare the expression patterns of each subunit.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Na(+)/K(+) ATPase alpha(+) subunit
, Na(+)/K(+) ATPase alpha-2 subunit
, sodium pump subunit alpha-2
, sodium/potassium-transporting ATPase subunit alpha-2
, ATPase, Na+K+ transporting, alpha 2
, Na+/K+ -ATPase alpha 2 subunit
, Na+/K+ ATPase, alpha-A(+) catalytic polypeptide
, Na+/K+ ATPase, alpha-B polypeptide
, sodium-potassium ATPase catalytic subunit alpha-2
, sodium/potassium-transporting ATPase alpha-2 chain
, ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide
, Na,K-ATPase alpha-2-subunit
, Na+/K+ transporting alpha 2 polypeptide
, Na,K-ATPase alpha 2 subunit
, Sodium pump subunit alpha-2
, ATPase, Na+/K+ transporting, alpha 2 polypeptide
, LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-2
, Na/K ATPase alpha 2 subunit
, ATPase, Na+/K+ transporting, alpha 2 polypeptide L homeolog
, ATPase, Na+/K+ transporting, alpha 2 polypeptide S homeolog
, ATPase Na+/K+ transporting subunit alpha 4
, sodium/potassium-transporting ATPase subunit alpha-4