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UPR transducer BBF2H7 allows export of type II collagen (show COL2A1 ELISA Kits) in a cargo- and developmental stage-specific manner.
These data suggest that the secreted luminal BBF2H7 C-terminus is involved in Hedgehog (show SHH ELISA Kits) ligand-dependent cancer cell proliferation through activation of Hedgehog (show SHH ELISA Kits) signaling. BBF2H7 C-terminus may be a novel target for the development of anticancer drugs.
Fbxw7 (show FBXW7 ELISA Kits) controls osteogenesis and chondrogenesis by targeting OASIS (show CREB3L1 ELISA Kits) and BBF2H7, respectively, for degradation.
the BBF2H7-mediated Sec23A (show SEC23A ELISA Kits) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis
FUS (show FUS ELISA Kits)-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 (show CD24 ELISA Kits) and FOXL1 (show FOXL1 ELISA Kits).
We characterized a widely expressed transcript of CREB3L2 generated by an intronic polyadenylation site in intron 4 of the gene.
The human Creb3L2 can activate SPCG transcription in a heterologous system(Drosophila embryos), which suggests a general and direct role for this family of bZip transcription factors in mediating high-level secretory capacity.
Fusion of the FUS (show FUS ELISA Kits) and CREB3L2 genes in a supernumerary ring chromosome is associated with low-grade fibromyxoid sarcoma.
BBF2H7 was fused with FUS (show FUS ELISA Kits) in a low grade myxoid liposarcoma.
CREB3L2 is not only structurally, but also functionally very similar to CREB3L1 (show CREB3L1 ELISA Kits).
novel regulatory mechanisms of Sox9 (show SOX9 ELISA Kits) for controlling the secretion of cartilage matrix proteins through the activation of BBF2H7-Sec23a (show SEC23A ELISA Kits) signaling during chondrogenesis
The dual N- and C-terminal functions of BBF2H7 triggered by physiological ER stress may allow chondrocytes to simultaneously regulate distinct cellular events for differentiation and proliferation in developing cartilage.
BBF2H7-ATF5 (show ATF5 ELISA Kits)-MCL1 (show MCL1 ELISA Kits) pathway specifically suppressed ER stress-induced apoptosis in chondrocytes.
induction by RAS-mitogen-activated protein kinase (show MAPK1 ELISA Kits) or phosphoinositide-3-kinase signaling cascade, which directly activates ATF5 (show ATF5 ELISA Kits) expression and glioma survival
Zebrafish feelgood mutation causes a single amino acid substitution within the DNA-binding domain of transcription factor Creb3l2.[Feelgood]
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene.
cAMP responsive element binding protein 3-like 2
, cyclic AMP-responsive element-binding protein 3-like protein 2-like
, B-ZIB transcription factor
, BBF2 human homolog on chromosome 7
, FUS/BBF2H7 protein
, basic transcription factor 2
, cAMP-responsive element-binding protein 3-like protein 2
, cyclic AMP-responsive element-binding protein 3-like protein 2
, SCI-related protein Ra69