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Beta-TrCP (show BTRC ELISA Kits) controls ubiquitination and degradation of liver-enriched transcription factor CREB-H.
Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance.
CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 (show FOSB ELISA Kits) target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes.
Taken together, our results demonstrated that human APOA5 (show APOA5 ELISA Kits) is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis
Studies indicate that mutations in CREB3L3 in individuals with extreme hypertriglyceridemia.
a novel mechanism of action of activated CB1R (show CNR1 ELISA Kits) signaling to induce hepatic gluconeogenesis via direct activation of CREBH
Levels of CREB (show CREB1 ELISA Kits) transcripts did NOT significantly differ in the thyroid adenomas and surrounding normal tissues.
analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis
findings show that CREBH an endoplasmic reticulum stress-activated transcription factor, binds to and transactivates the hepcidin (show HAMP ELISA Kits) promoter
Ldlr (show LDLR ELISA Kits)(-/-) Creb3l3(-/-) mice developed significantly more atherosclerotic lesions in the aortas than Ldlr (show LDLR ELISA Kits)(-/-) mice.
studies reveal that CREBH functions as a circadian-regulated liver transcriptional regulator that integrates energy metabolism with circadian rhythm.
Very Low Density Lipoprotein (VLDL) assembly and CREBH activation play key roles in the response to hepatic steatosis by up-regulating apoA-IV (show APOA4 ELISA Kits) and promoting assembly and secretion of larger, more triglyceride - enriched VLDL particles.
fasting or glucagon (show GCG ELISA Kits) stimulation modulates lipid homeostasis through acetylation of CREBH.
Overexpression of nuclear CREB3L3 induced systemic lipolysis, hepatic ketogenesis, and insulin (show INS ELISA Kits) sensitivity with increased energy expenditure.
CREBH-Fsp27beta axis is important for regulating lipid droplet dynamics and triglyceride storage in the liver
CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 (show JUN ELISA Kits) target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes.
Alpha lipoic acid (ALA) increases hepatic FGF21 (show FGF21 ELISA Kits) expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21 (show FGF21 ELISA Kits)
Orphan nuclear receptor (show NR1D1 ELISA Kits) Errgamma (show ESRRG ELISA Kits) induces C-reactive protein (show CRP ELISA Kits) gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH.
analysis of the transcriptional regulatory axis of CREBH-PPARalpha (show PPARA ELISA Kits)-FGF21 (show FGF21 ELISA Kits) that has a role in maintaining lipid homeostasis under metabolic stress
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants.
CREB/ATF family transcription factor
, cyclic AMP-responsive element-binding protein 3-like protein 3
, cAMP-responsive element-binding protein 3-like protein 3
, transcription factor CREB-H
, cAMP-responsive element-binding protein 3-like protein 3-A
, cAMP-responsive element-binding protein 3-like protein 3-B
, cyclic AMP-responsive element-binding protein 3-like protein 3-A
, cyclic AMP-responsive element-binding protein 3-like protein 3-B