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The cloning of porcine CREB3L4 and its alternative splicing variant, is reported.
AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells.
identified a novel human CREB (show CREB1 Proteins) gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues
S1P (show MBTPS1 Proteins) cleavage of CREB4 may be suppressed by a determinant in the C-terminal region
In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis.
Tisp40 aggravates tubular cells apoptosis in renal ischemia reperfusion injury.
these findings suggest that Tisp40 plays a critical role in the TGF-beta (show TGFB1 Proteins)/ Smads pathway involved in this process. Hence, Tisp40 could be a useful therapeutic target in the fight against renal tubulointerstitial fibrosis
Creb3l4 is an essential negative regulator of adipogenesis.
TISP40 functions by binding to the unfolded protein response element via the Rip pathway.
Creb3l4 plays a role in male germ cell development
Tisp40 and CREM (show CREM Proteins) bind to the Tisp40 promoter in vivo
we show that Atce1/Tisp40alpha is the major form of CREB3L4 in mouse testis. These findings suggest that testis-specific (show AIF1 Proteins) isoforms of Creb3l4 could play an important role in spermatid differentiation.
Expression of full-length ATCE1 in various cell lines revealed ER and Golgi localization whereas truncation of the C-terminus allowed entrance into the nucleus. A speculation that ATCE1 might be paternally delivered to newly formed zygote is discussed.
Disruption of TISP40 caused ER stress and activation of caspase 12 but not caspase 9 (show CASP9 Proteins), leading to apoptosis of meiotic/postmeiotic germ cells.
This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene.
cAMP responsive element binding protein 3-like 4
, cAMP-responsive element-binding protein 3-like protein 4
, cyclic AMP-responsive element-binding protein 3-like protein 4
, androgen-induced basic leucine zipper
, cyclic AMP-responsive element-binding protein 3-like protein 4-like
, androgen-induced basic leucine zipper protein
, attaching to CRE-like 1
, cAMP responsive element binding protein 1
, cAMP-responsive element-binding protein 4
, cyclic AMP-responsive element-binding protein 4
, transcript induced in spermiogenesis protein 40
, (attaching to CRE-like 1
, androgen-induced bZIP protein