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overexpression of Gpx6 (show GPX7 Proteins) can dramatically alleviate both behavioral and molecular phenotypes associated with a mouse model of Huntington's disease.
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidases catalyze the reduction of a variety of hydroperoxides, using glutathione as a specific electron donor substrate. The mouse and the rat orthologs contain Cys, unlike their human counterpart, which is a selenoprotein containing Sec (selenocysteine) at its active site. Expression of this gene is restricted to embryos and adult olfactory epithelium.
glutathione peroxidase 6
, odorant-metabolizing protein RY2D1
, glutathione peroxidase pseudogene 3