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Browse our anti-GNAS (GNAS) Antibodies

Full name:
anti-GNAS Complex Locus Antibodies (GNAS)
On www.antibodies-online.com are 145 GNAS Complex Locus (GNAS) Antibodies from 18 different suppliers available. Additionally we are shipping GNAS Proteins (16) and GNAS Kits (9) and many more products for this protein. A total of 184 GNAS products are currently listed.
Synonyms:
5530400H20Rik, A930027G11Rik, AHO, C20orf45, C130027O20Rik, G-alpha-S, Galphas, gnal, GNAS, gnas-a, GNAS1, Gnasxl, Gnpas, GPSA, GSA, GSP, NESP, Nesp55, Nespl, Oed-Sml, Oedsml, P1, P2, P3, PHP1A, PHP1B, PHP1C, POH, PORGSA1, zgc:92392

Most Popular Reactivities for anti-GNAS (GNAS) Antibodies

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anti-Mouse (Murine) GNAS Antibodies:

anti-Human GNAS Antibodies:

anti-Rat (Rattus) GNAS Antibodies:

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Top referenced anti-GNAS Antibodies

  1. Cow (Bovine) Polyclonal GNAS Primary Antibody for IHC, WB - ABIN2775542 : Bagchi, Wu, French, Kim, Moniri, Daaka: Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells. in Cancer research 2008 (PubMed)
    Show all 3 references for ABIN2775542

  2. Cow (Bovine) Polyclonal GNAS Primary Antibody for EIA, WB - ABIN498036 : Nishihara, Amino, Maekawa, Yoshida, Ito, Kubota, Fukata, Miyauchi: Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan. in Endocrine journal 2009 (PubMed)

  3. Chicken Polyclonal GNAS Primary Antibody for WB - ABIN2776982 : Linglart, Mahon, Kerachian, Berlach, Hendy, Jüppner, Bastepe: Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3',5'-monophosphate formation mediated by human XLalphas. in Endocrinology 2006 (PubMed)

More Antibodies against GNAS Interaction Partners

Pig (Porcine) GNAS Complex Locus (GNAS) interaction partners

  1. The Galphas and Galphaq (show GNAQ Antibodies) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Antibodies), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Antibodies)/Galphaq (show GNAQ Antibodies) peptide interactions are predominantly hydrophobic.

  2. Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2 (show BCL2 Antibodies), Fas (show FAS Antibodies), and Caspase-3 (show CASP3 Antibodies), which are recognized as apoptosis related markers.

  3. study did not find any significant associations for polymorphisms in insulin (show INS Antibodies)-like grwoth factor 2, GTP Binding Protein (show RND1 Antibodies) alpha Subunits, Gs and melanocortin receptor 4 (show MC4R Antibodies) genes with reproductive traits of Polish Landrace and Large White pigs

  4. Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.

  5. Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.

  6. Review article on the human GNAS complex locus.

Mouse (Murine) GNAS Complex Locus (GNAS) interaction partners

  1. The Galphas and Galphaq (show GNAQ Antibodies) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Antibodies), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Antibodies)/Galphaq (show GNAQ Antibodies) peptide interactions are predominantly hydrophobic.

  2. Data show that inhibitory (Galphai2 (show GNAI2 Antibodies)) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 (show GNAI2 Antibodies) over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.

  3. Galphas depletion blocks the S1PR1 (show S1PR1 Antibodies)-activation induced VE-cadherin (show CDH5 Antibodies) stabilization at junctions.

  4. demonstrate that the ability of an MC4R (show MC4R Antibodies) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

  5. Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase (show CYP24A1 Antibodies) mRNA levels and for maintaining normal serum 1,25(OH)2D.

  6. Ventromedial hypothalamic Gsalpha/cyclic AMP (show TMPRSS5 Antibodies) signaling regulates glucose homeostasis and alters leptin (show LEP Antibodies) sensitivity in mice, particularly in the setting of excess caloric intake.

  7. findings suggest that XLalphas enhances Gq/11 signaling to mediate the renal actions of PTH (show PTH Antibodies) during early postnatal development.

  8. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

  9. a novel role of Galphas in control of neural progenitor asymmetric cell division via suppressing Numb (show NUMB Antibodies) mediated Notch (show NOTCH1 Antibodies) signaling inhibition

  10. This study highlights an important tumour suppressive function of Galphas-PKA, limiting the proliferation of epithelial stem cells and maintaining proper hair follicle homeostasis.

Human GNAS Complex Locus (GNAS) interaction partners

  1. Data suggest that GIPR (gastric inhibitory polypeptide receptor (show GIPR Antibodies)) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies.

  2. The Galphas and Galphaq (show GNAQ Antibodies) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A Antibodies), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A Antibodies)/Galphaq (show GNAQ Antibodies) peptide interactions are predominantly hydrophobic.

  3. GNAS mutations may be involved in the tumorigenesis of potentially malignant lobular endocervical glandular hyperplasia.

  4. GNAS mutation was not found in any colorectal cancer.

  5. Results suggest that G protein alpha (show GNAO1 Antibodies) S subunit (Galphas) plays a tumor-promoting role in renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) and possibly acts through a protein kinase A (PKA)-dependent pathway.

  6. Progressive osseous heteroplasia has been found to be associated with different phenotypes caused by inactivating GNAS mutations, which is why it cannot be categorized as one distinct Mendelian trait

  7. Data show that G protein (heterotrimeric guanine nucleotide-binding protein (show COASY Antibodies))-coupled receptor (GPR37L1 (show GPR37L1 Antibodies)) coupled to the G protein Galpha (show SUCLG1 Antibodies)(s) when heterologously expressed in cultured cells.

  8. Studies indicate that adenylate cyclase-stimulating G alpha protein (GNAS) mutation was identified in two branch-duct gastric-type intraductal papillary mucinous neoplasms of the pancreas (BrD-IPMN).

  9. Presence of GNAS mutations in aldosterone-producing adenomas, as well as in some cortisol-secreting adenomas.

  10. The genetic defect(s) leading in Pseudohypoparathyroidism Type Ib to epigenetic GNAS changes and thus PTH (show PTH Antibodies)-resistance remains unknown, but it seems unlikely that this disease variant is caused by heterozygous inherited or de novo mutations involving GNAS.

Cow (Bovine) GNAS Complex Locus (GNAS) interaction partners

  1. application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor (show ADRB2 Antibodies)

  2. crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor (show ADRB2 Antibodies) and nucleotide-free Gs heterotrimer

  3. the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex

  4. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+

Xenopus laevis GNAS Complex Locus (GNAS) interaction partners

  1. Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.

GNAS Antigen Profile

Antigen Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Alternative names and synonyms associated with GNAS

  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2 (gnal2) antibody
  • GNAS complex locus (GNAS) antibody
  • GNAS complex locus (gnas) antibody
  • GNAS complex locus (LOC100346323) antibody
  • GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas) antibody
  • GNAS complex locus (Gnas) antibody
  • 5530400H20Rik antibody
  • A930027G11Rik antibody
  • AHO antibody
  • C20orf45 antibody
  • C130027O20Rik antibody
  • G-alpha-S antibody
  • Galphas antibody
  • gnal antibody
  • GNAS antibody
  • gnas-a antibody
  • GNAS1 antibody
  • Gnasxl antibody
  • Gnpas antibody
  • GPSA antibody
  • GSA antibody
  • GSP antibody
  • NESP antibody
  • Nesp55 antibody
  • Nespl antibody
  • Oed-Sml antibody
  • Oedsml antibody
  • P1 antibody
  • P2 antibody
  • P3 antibody
  • PHP1A antibody
  • PHP1B antibody
  • PHP1C antibody
  • POH antibody
  • PORGSA1 antibody
  • zgc:92392 antibody

Protein level used designations for GNAS

Galpha olf1 , Golf2 , guanine nucleotide-binding protein G(olf) subunit alpha , guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 , GNAS complex locus , guanine nucleotide binding protein, alpha stimulating, olfactory type , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like , Gs alpha subunit , adenylate cyclase-stimulating G alpha protein , alternative gene product encoded by XL-exon , extra large alphas protein , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas , neuroendocrine secretory protein 55 , protein ALEX , stimulatory G-protein alpha subunit , guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 , guanine nucleotide regulatory protein , neuroendocrine secretory protein , secretogranin VI , GTP-binding regulatory protein alpha subunit exon 1 , guanine nucleotide-binding protein G(s) subunit alpha , stimulatory GTP binding protein , alpha-stimulatory subunit of GTP-binding protein , guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1 , guanine nucleotide-binding protein G(s) subunit alpha isoforms , G-alpha-8 , GNAS , GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus , guanine nucleotide binding protein alpha s , guanine nucleotide-binding protein G-s, alpha subunit

GENE ID SPECIES
407724 Danio rerio
469986 Pan troglodytes
694289 Macaca mulatta
100151807 Sus scrofa
407931 Xenopus (Silurana) tropicalis
100021523 Monodelphis domestica
100346323 Oryctolagus cuniculus
100442753 Pongo abelii
100604281 Nomascus leucogenys
14683 Mus musculus
2778 Homo sapiens
403943 Canis lupus familiaris
100049657 Sus scrofa
281793 Bos taurus
24896 Rattus norvegicus
394414 Xenopus laevis
419313 Gallus gallus
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