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Browse our GNAS (GNAS) ELISA Kits

Full name:
GNAS Complex Locus ELISA Kits (GNAS)
On www.antibodies-online.com are 9 GNAS Complex Locus (GNAS) ELISA Kits from 2 different suppliers available. Additionally we are shipping GNAS Antibodies (139) and GNAS Proteins (16) and many more products for this protein. A total of 178 GNAS products are currently listed.
Synonyms:
5530400H20Rik, A930027G11Rik, AHO, C20orf45, C130027O20Rik, G-alpha-S, Galphas, gnal, GNAS, gnas-a, GNAS1, Gnasxl, Gnpas, GPSA, GSA, GSP, NESP, Nesp55, Nespl, Oed-Sml, Oedsml, P1, P2, P3, PHP1A, PHP1B, PHP1C, POH, PORGSA1, zgc:92392

More ELISA Kits for GNAS Interaction Partners

Pig (Porcine) GNAS Complex Locus (GNAS) interaction partners

  1. The Galphas and Galphaq (show GNAQ ELISA Kits) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A ELISA Kits), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A ELISA Kits)/Galphaq (show GNAQ ELISA Kits) peptide interactions are predominantly hydrophobic.

  2. Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2 (show BCL2 ELISA Kits), Fas (show FAS ELISA Kits), and Caspase-3 (show CASP3 ELISA Kits), which are recognized as apoptosis related markers.

  3. study did not find any significant associations for polymorphisms in insulin (show INS ELISA Kits)-like grwoth factor 2, GTP Binding Protein (show RND1 ELISA Kits) alpha Subunits, Gs and melanocortin receptor 4 (show MC4R ELISA Kits) genes with reproductive traits of Polish Landrace and Large White pigs

  4. Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.

  5. Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.

  6. Review article on the human GNAS complex locus.

Mouse (Murine) GNAS Complex Locus (GNAS) interaction partners

  1. Authors demonstrated that Nesp55 is co-localized with serotonin and then went on to show that in midbrain regions there were reductions in mRNA expression of the serotonin-specific genes Tph2 (show TPH2 ELISA Kits) and Slc6a4 (show SLC6A4 ELISA Kits), but not the dopamine-specific gene Th in Nesp(m/+) mice.

  2. Disruption of Gnas in smooth muscle of mi (show FOXF1 ELISA Kits)ce redu (show CREB1 ELISA Kits)ced intestinal motility an (show CREB1 ELISA Kits)d led to death within 4 weeks. GNAS disruption in adults impaired contraction of intestinal smooth muscle and peristalsis with features of intestinal pseudo-obstruction characterized by chronic intestinal dilation and dysmotility.

  3. The Galphas and Galphaq (show GNAQ ELISA Kits) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A ELISA Kits), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A ELISA Kits)/Galphaq (show GNAQ ELISA Kits) peptide interactions are predominantly hydrophobic.

  4. Data show that inhibitory (Galphai2 (show GNAI2 ELISA Kits)) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 (show GNAI2 ELISA Kits) over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.

  5. Galphas depletion blocks the S1PR1 (show S1PR1 ELISA Kits)-activation induced VE-cadherin (show CDH5 ELISA Kits) stabilization at junctions.

  6. demonstrate that the ability of an MC4R (show MC4R ELISA Kits) agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha

  7. Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase (show CYP24A1 ELISA Kits) mRNA levels and for maintaining normal serum 1,25(OH)2D.

  8. Ventromedial hypothalamic Gsalpha/cyclic AMP (show TMPRSS5 ELISA Kits) signaling regulates glucose homeostasis and alters leptin (show LEP ELISA Kits) sensitivity in mice, particularly in the setting of excess caloric intake.

  9. findings suggest that XLalphas enhances Gq/11 signaling to mediate the renal actions of PTH (show PTH ELISA Kits) during early postnatal development.

  10. acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.

Human GNAS Complex Locus (GNAS) interaction partners

  1. There were decreased levels of Gsa, FOXF1 (show FOXF1 ELISA Kits), CREB1 (show CREB1 ELISA Kits), and phosphorylated CREB1 (show CREB1 ELISA Kits) proteins in intestinal muscle layers of patients with chronic intestinal pseudo-obstruction, compared with tissues from controls.

  2. The molecular analysis of the GNAS gene in PHP (show ASAH1 ELISA Kits) and locus identified the causal alteration in 74 subjects (46 genetic and 28 epigenetic mutations). The clinical data at the diagnosis and their evolution during up to 15 years follow-up were collected using two different cards.

  3. 12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-gamma-linolenic acid, inhibits thrombosis via Galphas signaling in platelets.

  4. CGRP (show S100A12 ELISA Kits) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq (show GNAQ ELISA Kits)/11 pathways.

  5. acylation-deacylation cycle is important for the steady-state localization of Galphas at the plasma membrane, but our results do not support a role for deacylation in activity-dependent Galphas internalization.

  6. Data suggest that GIPR (gastric inhibitory polypeptide receptor (show GIPR ELISA Kits)) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies.

  7. The Galphas and Galphaq (show GNAQ ELISA Kits) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A ELISA Kits), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A ELISA Kits)/Galphaq (show GNAQ ELISA Kits) peptide interactions are predominantly hydrophobic.

  8. GNAS mutations may be involved in the tumorigenesis of potentially malignant lobular endocervical glandular hyperplasia.

  9. GNAS mutation was not found in any colorectal cancer.

  10. Results suggest that G protein alpha (show GNAO1 ELISA Kits) S subunit (Galphas) plays a tumor-promoting role in renal cell carcinoma (RCC (show XRCC1 ELISA Kits)) and possibly acts through a protein kinase A (PKA)-dependent pathway.

Cow (Bovine) GNAS Complex Locus (GNAS) interaction partners

  1. application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor (show ADRB2 ELISA Kits)

  2. crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor (show ADRB2 ELISA Kits) and nucleotide-free Gs heterotrimer

  3. the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex

  4. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+

Xenopus laevis GNAS Complex Locus (GNAS) interaction partners

  1. Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.

GNAS Antigen Profile

Antigen Summary

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Alternative names and synonyms associated with GNAS

  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2 (gnal2) Elisa Kit
  • GNAS complex locus (GNAS) Elisa Kit
  • GNAS complex locus (gnas) Elisa Kit
  • GNAS complex locus (LOC100346323) Elisa Kit
  • GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas) Elisa Kit
  • GNAS complex locus (Gnas) Elisa Kit
  • 5530400H20Rik Elisa Kit
  • A930027G11Rik Elisa Kit
  • AHO Elisa Kit
  • C20orf45 Elisa Kit
  • C130027O20Rik Elisa Kit
  • G-alpha-S Elisa Kit
  • Galphas Elisa Kit
  • gnal Elisa Kit
  • GNAS Elisa Kit
  • gnas-a Elisa Kit
  • GNAS1 Elisa Kit
  • Gnasxl Elisa Kit
  • Gnpas Elisa Kit
  • GPSA Elisa Kit
  • GSA Elisa Kit
  • GSP Elisa Kit
  • NESP Elisa Kit
  • Nesp55 Elisa Kit
  • Nespl Elisa Kit
  • Oed-Sml Elisa Kit
  • Oedsml Elisa Kit
  • P1 Elisa Kit
  • P2 Elisa Kit
  • P3 Elisa Kit
  • PHP1A Elisa Kit
  • PHP1B Elisa Kit
  • PHP1C Elisa Kit
  • POH Elisa Kit
  • PORGSA1 Elisa Kit
  • zgc:92392 Elisa Kit

Protein level used designations for GNAS Complex Locus (GNAS) ELISA Kits

Galpha olf1 , Golf2 , guanine nucleotide-binding protein G(olf) subunit alpha , guanine nucleotide binding protein, alpha stimulating activity polypeptide 1 , GNAS complex locus , guanine nucleotide binding protein, alpha stimulating, olfactory type , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like , Gs alpha subunit , adenylate cyclase-stimulating G alpha protein , alternative gene product encoded by XL-exon , extra large alphas protein , guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas , neuroendocrine secretory protein 55 , protein ALEX , stimulatory G-protein alpha subunit , guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 , guanine nucleotide regulatory protein , neuroendocrine secretory protein , secretogranin VI , GTP-binding regulatory protein alpha subunit exon 1 , guanine nucleotide-binding protein G(s) subunit alpha , stimulatory GTP binding protein , alpha-stimulatory subunit of GTP-binding protein , guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1 , guanine nucleotide-binding protein G(s) subunit alpha isoforms , G-alpha-8 , GNAS , GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus , guanine nucleotide binding protein alpha s , guanine nucleotide-binding protein G-s, alpha subunit

GENE ID SPECIES
407724 Danio rerio
469986 Pan troglodytes
694289 Macaca mulatta
100151807 Sus scrofa
407931 Xenopus (Silurana) tropicalis
100021523 Monodelphis domestica
100346323 Oryctolagus cuniculus
100442753 Pongo abelii
100604281 Nomascus leucogenys
14683 Mus musculus
2778 Homo sapiens
403943 Canis lupus familiaris
100049657 Sus scrofa
281793 Bos taurus
24896 Rattus norvegicus
394414 Xenopus laevis
419313 Gallus gallus
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