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Human Polyclonal HSP90B1 Primary Antibody for IHC (f), ICC - ABIN966318
Green: The illusion of common ground and mythical pluralism. in The International journal of psycho-analysis 2005
Show all 3 Pubmed References
GRP94 is tightly associated with the cell surface of parietal cells from rabbit gastric mucosa, where it exhibits high-affinity binding for the adenosine receptor agonist NECA and specific inhibitor radicicol.
These data demonstrate the essential role of the gp96-TLR interaction in priming T cell immunity and provide further molecular basis for the coupling of gp96-mediated innate with adaptive immunity.
Heat-shock protein gp96 enhances T cell responses and protective potential to BCG (show SLC11A1 Antibodies) vaccine.
binding of PCSK9 (show PCSK9 Antibodies) to GRP94 protects LDLR (show LDLR Antibodies) from degradation likely by preventing early binding of PCSK9 (show PCSK9 Antibodies) to LDLR (show LDLR Antibodies)
These data indicate that macrophage gp96 is essential for protective immunity during Gram-negative pneumonia
gp96 participates in the generation of natural Treg cells, which might be involved in the control of liver regeneration in the periphery
These studies imply GRP78 (show HSPA5 Antibodies), but not GRP94, is required for mammary gland development.
GRP94 deficiency in the liver led to injury, LPC (show PCSK7 Antibodies) expansion, increased proliferation, activation of oncogenic signaling, progressive repopulation of GRP94-positive hepatocytes and HCC (show FAM126A Antibodies) development in aged mice.
GP96 serves as an essential chaperone for the cell-surface protein (show CD28 Antibodies) glycoprotein A repetitions predominant (GARP (show LRRC32 Antibodies)), which is a docking receptor for latent membrane-associated TGF-beta (show TGFB1 Antibodies) (mLTGF-beta).
this work uncovered the essential role of gp96 in regulating melanogenesis.
Deletion of CD24 (show CD24 Antibodies) impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells.
Immuno-stimulating peptide derived from HMGB1 (show HMGB1 Antibodies) is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines.
mutations in GRP94 that affect its IGF chaperone activity represent a novel causal genetic mechanism that limits IGF biosynthesis, quite a distinct mechanism from the known genes in the GH/IGF signaling network.
In this instance, the ATP5B (show ATP5B Antibodies)/CALR (show CALR Antibodies)/HSP90B1/HSPB1 (show HSPB1 Antibodies)/HSPD1 (show HSPD1 Antibodies)-signaling network was revealed as the predominant target which was associated with the majority of the observed protein-protein interactions. As a result, the identified targets may be useful in explaining the anticancer mechanisms of ursolic acid and as potential targets for colorectal cancer therapy.
High HSP90B1 expression is associated with non-small-cell lung cancer.
data suggest that the GRP94/CCT8 (show CCT8 Antibodies)/c-Jun (show JUN Antibodies)/EMT (show ITK Antibodies) signaling cascade might be a new therapeutic target for HCC (show FAM126A Antibodies)
We filtered four OSCC genes including SERPINB9 (show SERPINB9 Antibodies), SERPINE2 (show SERPINE2 Antibodies), GAK (show GAK Antibodies), and HSP90B1 through the gene global prioritization score (P < 0.005).
Our results demonstrated that GRP94 is a key molecule in Hepatocellular carcinoma (HCC (show FAM126A Antibodies)) progression that modulates the AKT (show AKT1 Antibodies) pathway and eNOS (show NOS3 Antibodies) levels
Results indicate that FN14 (show TNFRSF12A Antibodies) and GRP94 are prediction/prognosis markers which open up new possibilities for preventing/treating brain metastasis in breast cancer patients.
This study clarifies a Grp94-mediated ERAD pathway for GABAA (show GABRg1 Antibodies) receptors, which provides a novel way to finely tune their function in physiological and pathophysiological conditions.
structural maturation of the client protein substrate, rather than ATP binding or hydrolysis, serves as the primary signal for dissociation of GRP94-client protein complexes [GRP94]
These results identify a compact, intertwined quaternary conformation of native GRP94
This study showed that ubiquitinated ALK5 (show TGFBR1 Antibodies) and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 Antibodies) and ALK5 (show TGFBR1 Antibodies) interact with heat shock protein 90(HSP90 (show HSP90 Antibodies)).
In Xenopus, gp96 can prime CD8(+) T-cell effectors that are not MHC restricted.
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.
tumor rejection antigen (gp96) 1
, 94 kD glucose-regulated protein
, endoplasmin-like protein
, 94 kDa glucose-regulated protein
, endoplasmic reticulum resident protein 99
, heat shock protein 90 kDa beta member 1
, polymorphic tumor rejection antigen 1
, transforming growth factor alpha regulated gene 2
, tumor rejection antigen gp96
, heat shock protein 90kDa beta (grp94), member 1
, heat shock protein 90kDa beta (Grp94), member 1
, endothelial cell (HBMEC) glycoprotein
, stress-inducible tumor rejection antigen gp96
, tumor rejection antigen 1
, 98 kDa protein kinase
, PPK 98
, gp96 homolog
, heat shock protein 90kDa beta, member 1
, heat shock protein gp96
, HSP 108
, heat shock 108 kDa protein
, heat shock protein 108
, transferrin-binding protein