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Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.
TSHR gene mutations p.R528C and c.392+4del4 associated with congenital hypothyroidism.
this study shows that the TSHR is not main factor contributing to determining common genetic basis among Graves disease and alopecia areata
TSHR D727E polymorphism might be involved in the pathogenesis of toxic multinodular goiter
lncRNA PVT1 may contribute to tumorigenesis of thyroid cancer through recruiting EZH2 (show EZH2 ELISA Kits) and regulating TSHR expression.
experimentally verified contact of Ser (show SIGLEC1 ELISA Kits)-281 (ECD (show SHFM1 ELISA Kits)) and Ile-486 (TMD (show TTN ELISA Kits)) was subsequently utilized in docking homology models of the ECD (show SHFM1 ELISA Kits) and the TMD (show TTN ELISA Kits) to create a full-length model of a glycoprotein hormone receptor (show NR4A1 ELISA Kits)
TSHR gene polymorphisms are associated with typical symptoms in primary congenital hypothyroidism.
The eminent ratio of TSHr methylation in well-differentiated thyroid carcinoma against benign thyroidal nodules adduced that TSHr methylation status can be utilized as a tumor marker for well-differentiated thyroid cancer.
Thyroid-stimulating hormone receptor intronic polymorphisms are associated with the susceptibility to Graves' disease and Graves' ophthalmopathy in the Brazilian population, but do not appear to influence the disease course.
data support a structural model of the TSHR transmembrane domain with a bulged transmembrane helix TM2 (show TPM2 ELISA Kits) and a straight TM5 that is specific of glycoprotein hormone receptors
TSHR gene variants are associated with congenital hypothyroidism.
Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.
Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r (show IGF1R ELISA Kits) expression, and have Igf1r (show IGF1R ELISA Kits) protein and protein fragments in both cytoplasm and nucleus. Igf1r (show IGF1R ELISA Kits) mRNA levels were similar between TSHR KO and WT mice.
The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c (show SREBF1 ELISA Kits) activity.
These findings suggest that activation of TSHR directly inhibits FASN (show FASN ELISA Kits) expression in mature adipocytes, possibly mediated by PKA and ERK (show EPHB2 ELISA Kits)
A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder.
The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP secretion and HMGCR (show HMGCR ELISA Kits) up-regulation through the cAMP/PKA/pCREB signaling pathway.
findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development
The inhibition of hepatic PEPCK (show PEPCK ELISA Kits) and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice.
UCP-1 (show UCP1 ELISA Kits) and TSHR co-localized in retrobulbar adipose tissues in murine models of Graves' disease.
Cloned a thyroid-stimulating hormone receptor (TSHR) cDNA from thyroid glands. The sequence of this cDNA indicated that it encoded a 739 amino acid TSHR splice variant that lacked exon 5 (TSHR739).
Localization of thyrotropin receptor and thyroglobulin (show TG ELISA Kits) in the bovine corpus luteum.
analysis of activation switch in the thyrotropin receptor
Rhes (show RASD2 ELISA Kits) can interfere with the functional activity of wt and mutated TSHr.
Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit.
the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor
The equine TSHR is not responsive to equine chorionic gonadotropin but is more sensitive to human CG than the human TSHR
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
, thyroid-stimulating hormone receptor
, thyrotropin receptor
, seven transmembrane helix receptor
, thyrotropin receptor-I, hTSHR-I