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Human Monoclonal IRF3 Primary Antibody for WB - ABIN967306
Au, Moore, Lowther, Juang, Pitha: Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. in Proceedings of the National Academy of Sciences of the United States of America 1996
Show all 8 Pubmed References
Human Monoclonal IRF3 Primary Antibody for Inhibition, IF - ABIN967285
Darnell, Kerr, Stark: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. in Science (New York, N.Y.) 1994
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Mouse (Murine) Polyclonal IRF3 Primary Antibody for WB - ABIN1881465
Marichal, Bedoret, Mesnil, Pichavant, Goriely, Trottein, Cataldo, Goldman, Lekeux, Bureau, Desmet: Interferon response factor 3 is essential for house dust mite-induced airway allergy. in The Journal of allergy and clinical immunology 2010
Show all 5 Pubmed References
Human Polyclonal IRF3 Primary Antibody for IHC, ELISA - ABIN1002558
Malmgaard: Induction and regulation of IFNs during viral infections. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004
Show all 4 Pubmed References
Human Polyclonal IRF3 Primary Antibody for ICC, ELISA - ABIN1002559
Fitzgerald, McWhirter, Faia, Rowe, Latz, Golenbock, Coyle, Liao, Maniatis: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. in Nature immunology 2003
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Human Polyclonal IRF3 Primary Antibody for IF (cc), IF (p) - ABIN742688
Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection. in Journal of virology 2013
Show all 3 Pubmed References
Human Monoclonal IRF3 Primary Antibody for BR, IF - ABIN2689798
Hiscott, Pitha, Genin, Nguyen, Heylbroeck, Mamane, Algarte, Lin: Triggering the interferon response: the role of IRF-3 transcription factor. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999
Show all 3 Pubmed References
Human Polyclonal IRF3 Primary Antibody for IF (cc), IF (p) - ABIN742695
Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. in Journal of immunology (Baltimore, Md. : 1950) 2014
Human Polyclonal IRF3 Primary Antibody for IF (p), IHC (p) - ABIN682588
Fan, Li, Zhu, Sui, Chen, Deng, Sui, Wang: NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows. in Biotechnology letters 2016
Mouse (Murine) Polyclonal IRF3 Primary Antibody for IHC, WB - ABIN3023115
Zhong, Wang, Fang, Zhang, Luo, Shang, Ouyang, Ouyang, Chen, Xiao: Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. in PLoS ONE 2013
Following spring viremia of carp (show ANKRD1 Antibodies) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Antibodies) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Antibodies)-dependent regulatory mechanism fine-tuning IFN gene activation.
Interferon (show IFNA Antibodies) regulatory factor (IRF (show TRIM63 Antibodies))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.
Hepatitis A virus protein 2B suppresses beta interferon (show IFNA Antibodies) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
MyD88 (show MYD88 Antibodies) interacts with interferon (show IFNA Antibodies) regulatory factor (IRF) 3 and IRF7 (show IRF7 Antibodies) in Atlantic salmon (Salmo salar)
IRF-3 gene polymorphisms were associated with the susceptibility and prognosis of CLL, it can be used as an auxiliary index for clinical detection of CLL.
Clarithromycin acts a crucial modulator of the innate immune response, particularly IFN production, by modulating IRF-3 dimerization and subsequent translocation to the nucleus of airway epithelial cells.
c-Cbl (show CBL Antibodies) negatively regulates IFN-beta (show IFNB1 Antibodies) signaling and cellular antiviral response by promoting IRF3 ubiquitination and degradation.
data describe an unappreciated role for EAP30 in IRF3-dependent innate antiviral response in the nucleus.
IRF-3 is an important regulator of ORMDL3 (show ORMDL3 Antibodies) induction following RSV infection by binding directly to the promoter of ORMDL3 (show ORMDL3 Antibodies)
above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro).
NEMO (show IKBKG Antibodies)-IKKbeta (show IKBKB Antibodies) Are Essential for IRF3 and NF-kappaB (show NFKB1 Antibodies) Activation in the cGAS-STING Pathway
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 (show TBK1 Antibodies) and thereby hinders the association of TBK1 (show TBK1 Antibodies) with its substrate IRF3, thus blocking IRF3 activation and transcriptional induction of the cellular antiviral responses.
IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis
this study shows that IRF-3-mediated apoptosis of virus-infected cells could be an effective antiviral mechanism, without expression of the interferon (show IFNA Antibodies)-stimulated genes
The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha (show IFNA Antibodies)/beta production.
The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (show IFNB1 Antibodies) promoter activity in MARC (show CCL7 Antibodies)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.
proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).
Interruption of IRF3-dependent signaling resulted in decreased cardiac expression of inflammatory cytokines and chemokines and decreased inflammatory cell infiltration of the heart, as well as in attenuated ventricular dilation and improved cardiac function.
This study reveals a critical role of NSD3 (show WHSC1L1 Antibodies)-mediated IRF3 methylation in enhancing antiviral innate immunity.
these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 (show EGR2 Antibodies) and YY1 (show YY1 Antibodies) in NIH3T3 cells
Data show that stimulator of interferon (show IFNA Antibodies) genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3-independent immune cell dysregulation and lung disease in mice.
study provided evidence that the ability of ICP34.5 to control IRF3 activation is through its ability to reverse translational shutoff and sustain the expression of other IFN inhibitors encoded by the virus
This study did not find non-conservative mutations among SJL, B10.S, B6 and B10 mice in the IRF3 amino acid sequence, and show SJL bone marrow-derived macrophages infected with Theiler's murine encephalomyelitis virus exhibit increased virus RNA replication and infectious virus yields as well as greater IL-6 production than C57Bl strain (including B10.S) cultures.
The IRF-3 pathway is essential for tick-borne encephalitis virus-induced RANTES (show CCL5 Antibodies) production in the brain.
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (show IFNB1 Antibodies) promoter activity and induces IRF3 degradation.
cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon (show IFNA Antibodies) synthesis.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
interferon regulatory factor 3
, interferon regulatory factor 3-like