Browse our Interferon Regulatory Factor 3 Proteins (IRF3)

Full name:
Interferon Regulatory Factor 3 Proteins (IRF3)
On www.antibodies-online.com are 20 Interferon Regulatory Factor 3 (IRF3) Proteins from 9 different suppliers available. Additionally we are shipping Interferon Regulatory Factor 3 Antibodies (298) and Interferon Regulatory Factor 3 Kits (31) and many more products for this protein. A total of 366 Interferon Regulatory Factor 3 products are currently listed.
Synonyms:
C920001K05Rik, IRF-3, IRF3
list all proteins Gene Name GeneID UniProt
IRF3 3661 Q14653
IRF3 54131 P70671
Rat IRF3 IRF3 292892  

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Interferon Regulatory Factor 3 Proteins (IRF3) by Origin

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Top referenced Interferon Regulatory Factor 3 Proteins

  1. Human IRF3 Protein expressed in Wheat germ - ABIN2752829 : Wang, Li, Dorf: NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. in PLoS ONE 2012 (PubMed)
    Show all 3 references for 2752829

  2. Human IRF3 Protein expressed in Escherichia coli (E. coli) - ABIN667046 : DeFilippis, Robinson, Keck, Hansen, Nelson, Früh: Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. in Journal of virology 2005 (PubMed)
    Show all 2 references for 667046

More Proteins for Interferon Regulatory Factor 3 Interaction Partners

Zebrafish Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Following spring viremia of carp (show ANKRD1 Proteins) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Proteins) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Proteins)-dependent regulatory mechanism fine-tuning IFN gene activation.

  2. Interferon (show IFNA Proteins) regulatory factor (IRF (show TRIM63 Proteins))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.

Rhesus Monkey Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Hepatitis A virus protein 2B suppresses beta interferon (show IFNA Proteins) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.

Atlantic Salmon (Salmo salar) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. MyD88 (show MYD88 Proteins) interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 and IRF7 (show IRF7 Proteins) in Atlantic salmon (Salmo salar)

Human Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3), a transcription factor central for IFN-beta (show IFNB1 Proteins) and IFN-stimulated gene expression.

  2. 1,8-cineole potentiates the antiviral activity of IRF3 in addition to its inhibitory effect on proinflammatory NF-kappaB (show NFKB1 Proteins) signaling in an ex vivo model of rhinosinusitis.

  3. TBK1 (show TBK1 Proteins) complexes required for the phosphorylation of IRF3 and the production of interferon-beta (show IFNB1 Proteins) have been identified.

  4. RIG-I (show DDX58 Proteins)-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway

  5. cGAs recognizes bacterial/viral DNA, and is a strong activator of STING that can further activate IRF3 and subsequent type I interferon (show IFNA Proteins) production. (Review)

  6. IRF3 overexpression in Acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) promotes cell growth and survival, and miR (show MLXIP Proteins)-155 is involved, indicating that IRF3 may be a potential new biomarker and therapeutic target for AML (show RUNX1 Proteins).

  7. down-regulation of IRF3 inhibited the proliferation and extracellular matrix expression in keloid fibroblasts.

  8. rotavirus NSP1 (show SH2D3A Proteins) (nonstructural protein 1) employs a pLxIS motif to target IRF-3 for degradation, but phosphorylation of NSP1 (show SH2D3A Proteins) is not required for its activity. These results suggest a concerted mechanism for the recruitment and activation of IRF-3 that can be subverted by viral proteins to evade innate immune responses.

  9. Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta (show IFNB1 Proteins) expression mainly through attenuating IRF-3 phosphorylation.

  10. Data suggest that molecular chaperone (show HSP90AA1 Proteins) GRP78 (show HSPA5 Proteins) contributes to toll-like receptor-3 (TLR3 (show TLR3 Proteins))-mediated, interferon regulatory factor 3 protein (IRF3)-dependent innate immune response to hepatitis C virus (HCV) in hepatocytes.

Pig (Porcine) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex.

  2. Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha (show IFNA Proteins)/beta production.

  3. The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (show IFNB1 Proteins) promoter activity in MARC (show CCL7 Proteins)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.

  4. proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).

Mouse (Murine) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Results establish Irf3, known mostly for its role in antiviral responses, as a transcription factor involved in the induction of Th2 responses through the promotion of pro-Th2 costimulation in CD11b (show ITGAM Proteins)(+) dendritic cells

  2. Rubicon (show KIAA0226 Proteins) specifically interacts with the interferon (show IFNA Proteins) regulatory factor (IRF (show TRIM63 Proteins)) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon (show IFNA Proteins)-mediated antiviral response.

  3. this study shows that IRF3 in antigen-presenting cells and T cells is required for optimal T-cell effector function and the ability of T cells to influence innate immune function of antigen-presenting cells

  4. The mitochondrial damage-cGAS-STING-IRF3 pathway is critically involved in metabolic stress-induced endothelial inflammation.

  5. TBK1 (show TBK1 Proteins) complexes required for the phosphorylation of IRF3 and the production of interferon-beta (show IFNB1 Proteins) have been identified.

  6. this study shows that lipopolysaccharide priming of dendritic cells stabilizes their tolerogenicity through reduction of NF-kappaB (show NFKB1 Proteins) and IRF3 signaling

  7. this study shows that regulation of the IRF3 pathway can affect multiple cell types and contribute to ameliorate pathogenesis of infection-triggered exacerbation of chronic obstructive pulmonary disease

  8. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Proteins))-STING membrane protein-TANK-binding kinase 1 (TBK1 (show TBK1 Proteins)) complex was necessary for the activation of interferon regulatory factor-3 (IRF3).

  9. characterizes SREBP cleavage-activating protein as an essential adaptor in the STING signaling pathway

  10. Study identifies crosstalk between PTEN and IRF3 in tumor suppression and innate immunity.

Cow (Bovine) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (show IFNB1 Proteins) promoter activity and induces IRF3 degradation.

  2. cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon (show IFNA Proteins) synthesis.

Interferon Regulatory Factor 3 (IRF3) Protein Profile

Protein Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Interferon Regulatory Factor 3 (IRF3)

  • interferon regulatory factor 3 (irf3)
  • interferon regulatory factor 3 (IRF3)
  • interferon regulatory factor 3 (irf-3)
  • interferon regulatory factor 3 (Irf3)
  • interferon regulatory factor 7 (IRF7)
  • C920001K05Rik protein
  • IRF-3 protein
  • IRF3 protein

Protein level used designations for IRF3

interferon regulatory factor 3 , interferon regulatory factor 3-like , IRF-3

GENE ID SPECIES
564854 Danio rerio
718970 Macaca mulatta
747565 Pan troglodytes
780485 Ovis aries
100337625 Salmo salar
100414132 Callithrix jacchus
100441280 Pongo abelii
100471184 Ailuropoda melanoleuca
3661 Homo sapiens
396656 Sus scrofa
54131 Mus musculus
292892 Rattus norvegicus
476412 Canis lupus familiaris
516979 Bos taurus
396330 Gallus gallus
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