You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our Interferon Regulatory Factor 3 Proteins (IRF3)

Full name:
Interferon Regulatory Factor 3 Proteins (IRF3)
On are 21 Interferon Regulatory Factor 3 (IRF3) Proteins from 10 different suppliers available. Additionally we are shipping Interferon Regulatory Factor 3 Antibodies (306) and Interferon Regulatory Factor 3 Kits (28) and many more products for this protein. A total of 372 Interferon Regulatory Factor 3 products are currently listed.
C920001K05Rik, IRF-3, IRF3
list all proteins Gene Name GeneID UniProt
IRF3 3661 Q14653
IRF3 54131 P70671
Rat IRF3 IRF3 292892  

Show all synonyms

Interferon Regulatory Factor 3 Proteins (IRF3) by Origin

Select your origin of interest

Top referenced Interferon Regulatory Factor 3 Proteins

  1. Human IRF3 Protein expressed in Wheat germ - ABIN2752829 : Wang, Li, Dorf: NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN2752829

  2. Human IRF3 Protein expressed in Escherichia coli (E. coli) - ABIN667046 : DeFilippis, Robinson, Keck, Hansen, Nelson, Früh: Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. in Journal of virology 2005 (PubMed)
    Show all 2 references for ABIN667046

More Proteins for Interferon Regulatory Factor 3 Interaction Partners

Zebrafish Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Interferon (show IFNA Proteins) regulatory factor (IRF (show TRIM63 Proteins))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.

Rhesus Monkey Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Hepatitis A virus protein 2B suppresses beta interferon (show IFNA Proteins) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.

Atlantic Salmon (Salmo salar) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. MyD88 (show MYD88 Proteins) interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 and IRF7 (show IRF7 Proteins) in Atlantic salmon (Salmo salar)

Human Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. down-regulation of IRF3 inhibited the proliferation and extracellular matrix expression in keloid fibroblasts.

  2. rotavirus NSP1 (show SH2D3A Proteins) (nonstructural protein 1) employs a pLxIS motif to target IRF-3 for degradation, but phosphorylation of NSP1 (show SH2D3A Proteins) is not required for its activity. These results suggest a concerted mechanism for the recruitment and activation of IRF-3 that can be subverted by viral proteins to evade innate immune responses.

  3. Highly pathogenic Porcine reproductive and respiratory syndrome virus modulates Interferon-beta (show IFNB1 Proteins) expression mainly through attenuating IRF-3 phosphorylation.

  4. Data suggest that molecular chaperone (show HSP90AA1 Proteins) GRP78 (show HSPA5 Proteins) contributes to toll-like receptor-3 (TLR3 (show TLR3 Proteins))-mediated, interferon regulatory factor 3 protein (IRF3)-dependent innate immune response to hepatitis C virus (HCV) in hepatocytes.

  5. Findings suggest a common and conserved mechanism through which highly pathogenic MERS-CoV and SARS (show SARS Proteins)-CoV harness their M proteins to suppress type I IFN expression at the level of TBK1 (show TBK1 Proteins)-dependent phosphorylation and activation of IRF3 resulting in evasion of the host innate antiviral response.

  6. observations suggest IRF3 may function as a novel regulator to modulate TGF-beta1 (show TGFB1 Proteins)-induced LX-2 proliferation, at least in part, via AKT (show AKT1 Proteins) signaling pathway

  7. FAF1 (show FAF1 Proteins) plays a novel role in negatively regulating virus-induced IFN-beta (show IFNB1 Proteins) production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus

  8. the LxxLL motifs of IRF3 binds within the hydrophobic pocket of E6, precluding Ser (show SIGLEC1 Proteins)-patch phosphorylation, necessary for IRF3 activation and interferon (show IFNA Proteins) induction.

  9. the suppression of type I IFN production by HTLV-1 Tax (show CNTN2 Proteins) through interaction with and inhibition of TBK1 (show TBK1 Proteins) kinase that phosphorylates IRF3

  10. The authors found that Ca(2 (show CA2 Proteins)+) signaling associated with membrane perturbation and recognition of incoming viral genomes by cytosolic nucleic acid receptors are required to activate IRF3 in response to Sendai virus and human cytomegalovirus.

Pig (Porcine) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha (show IFNA Proteins)/beta production.

  2. The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (show IFNB1 Proteins) promoter activity in MARC (show CCL7 Proteins)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.

  3. proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).

Mouse (Murine) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. this study shows that regulation of the IRF3 pathway can affect multiple cell types and contribute to ameliorate pathogenesis of infection-triggered exacerbation of chronic obstructive pulmonary disease

  2. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Proteins))-STING membrane protein-TANK-binding kinase 1 (TBK1 (show TBK1 Proteins)) complex was necessary for the activation of interferon regulatory factor-3 (IRF3).

  3. characterizes SREBP cleavage-activating protein as an essential adaptor in the STING signaling pathway

  4. Study identifies crosstalk between PTEN and IRF3 in tumor suppression and innate immunity.

  5. results revealed a new paradigm in which the antiviral host factor, IRF3, plays a cell-intrinsic pro-parasitic role.

  6. Irf3/IFN activation in hematopoietic stem and progenitor cells expands multipotent progenitors fractions but inhibits HSC (show FUT1 Proteins) mobilization

  7. find that IRF3 versus ISGF3 (show IRF9 Proteins) specificity may be critical to limiting IFN-beta (show IFNB1 Proteins) production and ISGF3 (show IRF9 Proteins) activation, temporally and spatially, but that partial overlap in their specificity is tolerable and may enhance the effectiveness of the innate-immune response

  8. Bipartite nuclear localization signal controls nuclear import and DNA-binding activity of IRF3.

  9. Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26 (show TRIM26 Proteins)-mediated IRF3 ubiquitination and degradation.

  10. PP1 (show PPP1CC Proteins) directly interacts with IRF3 and dephosphorylates IRF3 at Ser385 and Ser396, resulting in the suppression of TLR- and RLR (show DHX58 Proteins)-triggered IFN-beta (show IFNB1 Proteins) production.

Cow (Bovine) Interferon Regulatory Factor 3 (IRF3) interaction partners

  1. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (show IFNB1 Proteins) promoter activity and induces IRF3 degradation.

  2. cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon (show IFNA Proteins) synthesis.

Interferon Regulatory Factor 3 (IRF3) Protein Profile

Protein Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Interferon Regulatory Factor 3 (IRF3)

  • interferon regulatory factor 3 (irf3)
  • interferon regulatory factor 3 (IRF3)
  • interferon regulatory factor 3 (irf-3)
  • interferon regulatory factor 3 (Irf3)
  • interferon regulatory factor 7 (IRF7)
  • C920001K05Rik protein
  • IRF-3 protein
  • IRF3 protein

Protein level used designations for IRF3

interferon regulatory factor 3 , interferon regulatory factor 3-like , IRF-3

564854 Danio rerio
718970 Macaca mulatta
747565 Pan troglodytes
780485 Ovis aries
100337625 Salmo salar
100414132 Callithrix jacchus
100441280 Pongo abelii
100471184 Ailuropoda melanoleuca
3661 Homo sapiens
396656 Sus scrofa
54131 Mus musculus
292892 Rattus norvegicus
476412 Canis lupus familiaris
516979 Bos taurus
396330 Gallus gallus
Selected quality suppliers for Interferon Regulatory Factor 3 Proteins (IRF3)
Did you look for something else?