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Functions of the two zebrafish MAVS (show MAVS Proteins) variants are opposite in the induction of IFN1 by targeting IRF7
The miR (show MYLIP Proteins)-142a-3p regulates HSC (show FUT1 Proteins) formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
MyD88 (show MYD88 Proteins) interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 (show IRF3 Proteins) and IRF7 in Atlantic salmon (Salmo salar)
Differences in transcription kinetics between IRF-7 and STAT1 (show STAT1 Proteins) indicate that genes are regulated through different pathways. Infection of TO cells with ISAV induced early synthesis of STAT1 (show STAT1 Proteins) mRNA, whereas IRF-7 transcripts were upregulated later.
The IRF7 GG genotype associate with Cognitive Decline and Dementia.
IRF7 cleavage by the 3C protease of enterovirus D68 abrogated its capacity to activate type I interferon (show IFNA Proteins) expression and limit virus replication.
Viral infection induced DAPK1 (show DAPK1 Proteins)-IRF7 and DAPK1 (show DAPK1 Proteins)-IRF3 (show IRF3 Proteins) interactions and overexpression of DAPK1 (show DAPK1 Proteins) enhanced virus-induced activation of the interferon (show IFNA Proteins)-stimulated response element (ISRE) and IFN-beta (show IFNB1 Proteins) promoters and the expression of the IFNB1 (show IFNB1 Proteins) gene.
Interferon regulatory factor 7 (IRF7) is a direct target of miR (show MLXIP Proteins)-762 and overexpression of miR (show MLXIP Proteins)-762 reduced expression of IRF7.
Data indicate that the type-I interferon (show IFNA Proteins) master regulator gene interferon regulatory factor 7 (IRF7) is only hypomethylated in lupus patients with renal involvement.
our results indicate that IRF7 promotes glioma cell invasion and both chemoresistance and radioresistance through AGO2 (show EIF2C2 Proteins) inhibition
The interaction between AIP (show AIP Proteins) and IRF7 is enhanced upon virus infection, and AIP (show AIP Proteins) potently inhibits IRF7-induced type I IFN (IFN-alpha/beta) production.
Authors found that knockdown of IRF7 leads to growth inhibition of Epstein-Barr virus-transformed cells, and restoration of IRF7 by exogenous plasmid correlates with growth recovery of the viral transformed cells.
In TSC2-deficient angiomyolipoma patient cells, IRF7 is a pivotal factor in the Rheb (show RHEB Proteins)/mTOR (show FRAP1 Proteins) pathway.
These findings suggest that IRF7-dependent amplification of type I and III IFNs is required for protection against primary infection by influenza virus in humans.
poly I:C augments IFN-gamma-induced (show SAMHD1 Proteins) NO production at the transcriptional level via enhanced IRF7 activation
IRF7 protects against vascular smooth muscle cell proliferation.
Data showed that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo.
Data suggest that Trim35 (tripartite motif-containing 35 (show TRIM35 Proteins)) down-regulates type I interferon (show IFNA Proteins) production in dendritic cells via toll (show TLR4 Proteins)-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Authors show that the capacity to undergo pro- to anti-inflammatory (M1-to-M2) phenotype switch is controlled by the transcription factor interferon regulatory factor 7 (IRF7) that is down-regulated by the TGFbeta1 (show TGFB1 Proteins) pathway.
Our data highlight a pivotal role of CCL7 (show CCL7 Proteins) and IRF-7 in rhinovirus-induced inflammation
These results establish a dominant protective role for MAVS (show MAVS Proteins), IRF-3 (show IRF3 Proteins) and IRF-7, and IFNAR (show IFNAR1 Proteins) in restricting Oropouche virus infection and tissue injury and suggest that IFN signaling in nonmyeloid cells contributes to the host defense.
IRF7 suppresses antiparasitic immunity in the spleen, while IFNAR1 (show IFNAR1 Proteins)-mediated, but IRF7-independent, signaling contributes to pathology in the brain during experimental blood-stage malaria.
IRF-3 (show IRF3 Proteins), IRF-7, and IPS-1 (show ISYNA1 Proteins) promote host defense against acute human metapneumovirus infection in neonatal mice
IRF7 acts as a novel negative regulator of pathological cardiac hypertrophy by inhibiting nuclear factor-kappaB signaling and may constitute a potential therapeutic target for pathological cardiac hypertrophy.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.
N(pro) of classical swine fever virus (CSFV) interacts with IRF7; Zn-binding domain of N(pro) is essential for the interaction; results show CSFV N(pro) is capable of manipulating function of IRF7 in plasmacytoid dendritic cells
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
interferon regulatory factor 7
, interferon regulatory factor 7-like
, interferon regulatory factor-7H
, interferon regulatory factor-7