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Following spring viremia of carp (show ANKRD1 Proteins) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Proteins) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Proteins)-dependent regulatory mechanism fine-tuning IFN gene activation.
Functions of the two zebrafish MAVS (show MAVS Proteins) variants are opposite in the induction of IFN1 by targeting IRF7
The miR (show MYLIP Proteins)-142a-3p regulates HSC (show FUT1 Proteins) formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
MyD88 (show MYD88 Proteins) interacts with interferon (show IFNA Proteins) regulatory factor (IRF) 3 (show IRF3 Proteins) and IRF7 in Atlantic salmon (Salmo salar)
Differences in transcription kinetics between IRF-7 and STAT1 (show STAT1 Proteins) indicate that genes are regulated through different pathways. Infection of TO cells with ISAV induced early synthesis of STAT1 (show STAT1 Proteins) mRNA, whereas IRF-7 transcripts were upregulated later.
The MYC (show MYC Proteins) is shown to be recruited to the IRF7 promoter region through interaction with nuclear receptor corepressor 2/histone deacetylase 3 (show HDAC3 Proteins) for its repression.
S100A9 knockdown almost completely abrogated the effects of IRF7 deletion on granulocytic myeloid-derived suppressor cells (G-MDSC) development and tumor metastasis. IRF7 represents a novel regulator for G-MDSC development in cancer and may have predictive value for tumor progression.
the transcription factor NFATC3 (show NFATC3 Proteins) binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells.
We show that IRF-7 siRNA knockdown enhanced LPS (show IRF6 Proteins)-induced IL-10 (show IL10 Proteins) production in human monocyte-derived macrophages, and USP-18 (show USP18 Proteins) overexpression attenuated LPS (show IRF6 Proteins)-induced production of IL-10 (show IL10 Proteins) in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18 (show USP18 Proteins), USP41, IL10 (show IL10 Proteins), and IRF7. An independent cohort confirmed LPS (show IRF6 Proteins) induction of USP41 and IL10 (show IL10 Proteins) genes
KSHV-encoded viral IRF4 (show IRF4 Proteins) interacts with the host IRF7 and inhibits interferon-alpha (show IFNA Proteins) production.
The adaptor molecule RAIDD (show CRADD Proteins) coordinates IKKepsilon (show IKBKE Proteins) and IRF7 interaction to ensure efficient expression of type I interferon (show IFNA Proteins).
Bcl6 (show BCL6 Proteins), by interacting with the co-factors NcoR2 and HDAC3 (show HDAC3 Proteins), plays a pivotal role in controlling IRF7 induction and antiviral signaling priming.
Human IRF7 was shown to be essential for interferon (show IFNA Proteins) type I-dependent protective immunity against primary influenza. (Review)
The IRF7 GG genotype associate with Cognitive Decline and Dementia.
IRF7 cleavage by the 3C protease of enterovirus D68 abrogated its capacity to activate type I interferon (show IFNA Proteins) expression and limit virus replication.
IRF7 represents a novel regulator of granulocytic myeloid-derived suppressor cells development in cancer, which may have predictive value for tumor progression.
a specific requirement for IRF7 in autoantibody production and uncovers a new layer of complexity in the pathogenesis of Systemic lupus erythematosus (SLE).
MiR (show MLXIP Proteins)-144 reduces the antiviral response by attenuating the TRAF6 (show TRAF6 Proteins)-IRF7 pathway to alter the cellular antiviral transcriptional landscape.
IRF7 directly binds to the two conserved IRF (show TRIM63 Proteins) binding sites on the USP25 (show USP25 Proteins) promoter to drive transcription of Usp25 (show USP25 Proteins).
poly I:C augments IFN-gamma-induced (show SAMHD1 Proteins) NO production at the transcriptional level via enhanced IRF7 activation
IRF7 protects against vascular smooth muscle cell proliferation.
Data showed that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo.
Data suggest that Trim35 (tripartite motif-containing 35 (show TRIM35 Proteins)) down-regulates type I interferon (show IFNA Proteins) production in dendritic cells via toll (show TLR4 Proteins)-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.
N(pro) of classical swine fever virus (CSFV) interacts with IRF7; Zn-binding domain of N(pro) is essential for the interaction; results show CSFV N(pro) is capable of manipulating function of IRF7 in plasmacytoid dendritic cells
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
interferon regulatory factor 7
, interferon regulatory factor 7-like
, interferon regulatory factor-7H
, interferon regulatory factor-7