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these results suggest that inhibition of PTP1B activity is a promising new target in the treatment of colorectal cancer and the prevention of metastasis
the molecular mechanisms by which PTP1B and TC-PTP (show PTPN2 ELISA Kits) loss co-operates with other genetic aberrations will need to be elucidated to design more effective therapeutic strategies.
Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B, which in turn activates the epidermal growth factor receptor (show EGFR ELISA Kits)-p38 mitogen-activated protein kinase (show MAPK14 ELISA Kits) pathway that induces cyclooxygenase-2 (show PTGS2 ELISA Kits) expression.
The findings show that reduced PTP1B responses contribute to disease symptoms in part by enhancing S100A9 (show S100A9 ELISA Kits) expression during viral-associated chronic obstructive pulmonary disease exacerbations.
Both the rs2904268 C>G CG and GG genotype frequencies were markedly higher in the ESCC group relative to the control group (both p < 0.05). However, the genotype frequencies of rs2230605A>G and rs16995309 C>T were similar between the ESCC and control groups These results indicated that the PTPN1 gene polymorphism rs2904268 is associated with susceptibility to Esophageal Squamous Cell Carcinoma in Inner Mongolia.
Data suggest TrxR1 (show TXNRD1 ELISA Kits) and NADPH (show NQO1 ELISA Kits) directly protect PTP1B from inactivation by oxidation; this protection is independent of TRX1 (show MLL ELISA Kits) and PRX2 (show PRDX2 ELISA Kits); this protection is blocked by auranofin (an inhibitor of TrxR1 (show TXNRD1 ELISA Kits) and requires an intact selenocysteine residue in TrxR1 (show TXNRD1 ELISA Kits). (TrxR1 (show TXNRD1 ELISA Kits) = thioredoxin reductase 1 (show TXNRD1 ELISA Kits); PTP1B = protein tyrosine phosphatase (show ACP1 ELISA Kits), non-receptor type 1; TRX1 (show MLL ELISA Kits) = thioredoxin-1 (show TXNL1 ELISA Kits); PRX2 (show PRDX2 ELISA Kits) = paired related homeobox 2 (show PRRX2 ELISA Kits) protein)
Regulation of platelet-activating factor-mediated PTP1B activation by a Janus kinase 2/ calpain pathway has been reported.
PTP1B was overexpressed in over 70% of breast cancer tissues, correlating with patients with estrogen receptor (ER (show ESR1 ELISA Kits))-negative, progesterone receptor (PR (show PGR ELISA Kits))-negative, and human epidermal growth factor receptor (show EGFR ELISA Kits) 2 (HER2 (show ERBB2 ELISA Kits))-positive tumors. The data also showed that both tumor size and lymph node metastasis were significantly higher in patients with a higher level of PTP1B.
PTP1B uses conformational and dynamic allostery to regulate its activity. Both conformational rigidity and dynamics are essential for controlling protein activity.
PTP1BDelta6 is a positive regulator of JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signaling in classical Hodgkin lymphoma cells.(
Under normoglycemia control and pod-PTP1B KO mice exhibited comparable renal functions. However, podocyte PTP1B disruption attenuated hyperglycemia-induced albuminuria and renal injury and preserved glucose control. Also, podocyte PTP1B disruption was accompanied with improved renal insulin (show INS ELISA Kits) signaling and enhanced autophagy with decreased inflammation and fibrosis.
Endothelial PTP1B deletion improves cardiac VEGF signalling and angiogenesis and protects against chronic afterload-induced heart failure.
PTP1B inhibitors protect against atherosclerotic plaque formation in the LDLR (show LDLR ELISA Kits)(-/-) mouse model of atherosclerosis.
The results suggest a deficiency of PTP1B improves hypothalamic insulin (show INS ELISA Kits) sensitivity resulting in the attenuation of AgRP (show AGRP ELISA Kits) mRNA expression under HFD conditions.
cadherin 2 (CDH2 (show CDH2 ELISA Kits)) and CDH4 (show CDH4 ELISA Kits) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins.
this paper shows that PTP1B specifically regulates IgE-mediated STAT5 (show STAT5A ELISA Kits) pathway, but is redundant in influencing mast cell function in vivo
PTP1B/RNF213 (show RNF213 ELISA Kits)/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 ELISA Kits)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis.
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
protein tyrosine phosphatase, non-receptor type 1
, tyrosine-protein phosphatase non-receptor type 1
, tyrosine-protein phosphatase non-receptor type 1-like
, protein tyrosine phosphatase, placental
, protein-tyrosine phosphatase 1B
, protein-protein-tyrosine phosphatase HA2
, protein-tyrosine phosphatase HA2
, protein tyrosine phosphatase 1b
, non-receptor protein tyrosine phosphatase
, phosphoprotein phosphatase
, tyrosine phosphatase 1B