Browse our anti-SARM1 (SARM1) Antibodies

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anti-Sterile alpha and TIR Motif Containing 1 Antibodies (SARM1)
On are 57 Sterile alpha and TIR Motif Containing 1 (SARM1) Antibodies from 15 different suppliers available. Additionally we are shipping SARM1 Proteins (3) and many more products for this protein. A total of 64 SARM1 products are currently listed.
A830091I15Rik, C78606, MyD88-5, MyD885, SAMD2, SARM
list all antibodies Gene Name GeneID UniProt
SARM1 237868 Q6PDS3
SARM1 23098 Q6SZW1
SARM1 287545  

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Most Popular Reactivities for anti-SARM1 (SARM1) Antibodies

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anti-Mouse (Murine) SARM1 Antibodies:

anti-Human SARM1 Antibodies:

anti-Rat (Rattus) SARM1 Antibodies:

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Top referenced anti-SARM1 Antibodies

  1. Human Polyclonal SARM1 Primary Antibody for ELISA, ICC - ABIN4352013 : Murata, Sakaguchi, Kataoka, Huh: SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. in Molecular biology of the cell 2013 (PubMed)

  2. Human Polyclonal SARM1 Primary Antibody for ICC, IF - ABIN4352017 : Rodet, Tasiemski, Boidin-Wichlacz, Van Camp, Vuillaume, Slomianny, Salzet: Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech. in Scientific reports 2015 (PubMed)

More Antibodies against SARM1 Interaction Partners

Mouse (Murine) Sterile alpha and TIR Motif Containing 1 (SARM1) interaction partners

  1. demonstrate that the NADase activity of full-length SARM1 is required in axons to promote axonal NAD+ depletion and axonal degeneration after injury.

  2. Genetic deletion of SARM1 decreases axonal degeneration in a mouse model of neuropathy.

  3. SARM is a potential regulator of sepsis-induced splenocyte apoptosis.

  4. Sarm1(-/-)mice developed fewer Beta-amyloid precursor protein aggregates in axons of corpus callosum after traumatic brain injury.

  5. MMP-12 (show MMP12 Antibodies) up-regulation mediated by SARM-TRIF (show RNF138 Antibodies) signaling pathway contributes to IFN-gamma (show IFNG Antibodies)-independent airway inflammation and AHR (show AHR Antibodies) post RSV infection in nude mice.

  6. SARM1, Not MyD88 (show MYD88 Antibodies), Mediates TLR7 (show TLR7 Antibodies)/TLR9 (show TLR9 Antibodies)-Induced Apoptosis in Neurons

  7. nicotinamide mononucleotide adenylyltransferase 2 (show NMNAT2 Antibodies)-depletion-dependent degeneration of established axons and restricted extension of developing axons are thus both SARM1 dependent

  8. SARM1-induced depletion of NAD(+) may explain the potent axon protection in Wallerian degeneration slow (Wld(s)) mutant mice.

  9. The findings suggest that Sarm1 regulates social behaviors and cognition.

  10. Therefore, Sarm1 functions downstream of ROS (show ROS1 Antibodies) to induce neuronal cell death and axon degeneration during oxidative stress.

Human Sterile alpha and TIR Motif Containing 1 (SARM1) interaction partners

  1. Active nerve degeneration requires SARM1 and MAP kinases, including DLK (show DAPK3 Antibodies), while the NAD+ synthetic enzyme NMNAT2 (show NMNAT2 Antibodies) prevents degeneration.

  2. Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions.

  3. These results indicate that association of PINK1 (show PINK1 Antibodies) with SARM1 and TRAF6 (show TRAF6 Antibodies) is an important step for mitophagy.

  4. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.

  5. Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1.

  6. Data found that the UXT (show UXT Antibodies) isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.

  7. SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon.

  8. The N-terminal 27 amino acids (S27 (show RPS27 Antibodies)) of SARM, which is hydrophobic and polybasic, acts as a mitochondria-targeting signal sequence, associating SARM to the mitochondria. The S27 (show RPS27 Antibodies) peptide has an inherent ability to bind to lipids and mitochondria.

  9. SARM-mediated inhibition may not be exclusively directed at TRIF (show TRIM69 Antibodies) or MyD88 (show MYD88 Antibodies), but that SARM may also directly inhibit MAPK (show MAPK1 Antibodies) phosphorylation

  10. TIR adaptor SARM is a negative regulator of Toll (show TLR4 Antibodies)-like receptor signaling.

SARM1 Antigen Profile

Antigen Summary

Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation (By similarity).

Alternative names and synonyms associated with SARM1

  • sterile alpha and TIR motif containing 1 (SARM1) antibody
  • sterile alpha and TIR motif containing 1 (LOC100349344) antibody
  • sterile alpha and HEAT/Armadillo motif containing 1 (Sarm1) antibody
  • sterile alpha and TIR motif containing 1 (Sarm1) antibody
  • sterile alpha and TIR motif containing 1 (sarm1) antibody
  • A830091I15Rik antibody
  • C78606 antibody
  • MyD88-5 antibody
  • MyD885 antibody
  • SAMD2 antibody
  • SARM antibody

Protein level used designations for SARM1

sterile alpha and TIR motif-containing protein 1 , sterile alpha and TIR motif containing 1 , Tir-1 homolog , SAM domain-containing protein 2 , sterile alpha and Armadillo repeat protein , sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila , sterile alpha motif domain-containing protein 2 , tir-1 homolog

491165 Canis lupus familiaris
100059075 Equus caballus
536256 Bos taurus
100349344 Oryctolagus cuniculus
237868 Mus musculus
23098 Homo sapiens
287545 Rattus norvegicus
403143 Danio rerio
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