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anti-Mouse (Murine) SARM1 Antibodies:
anti-Human SARM1 Antibodies:
anti-Rat (Rattus) SARM1 Antibodies:
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Human Polyclonal SARM1 Primary Antibody for EIA, IF - ABIN1449950
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
Show all 4 references for ABIN1449950
Human Polyclonal SARM1 Primary Antibody for ELISA, ICC - ABIN4352013
Murata, Sakaguchi, Kataoka, Huh: SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. in Molecular biology of the cell 2013
Sarm1(-/-)mice developed fewer Beta-amyloid precursor protein aggregates in axons of corpus callosum after traumatic brain injury.
MMP-12 (show MMP12 Antibodies) up-regulation mediated by SARM-TRIF (show RNF138 Antibodies) signaling pathway contributes to IFN-gamma (show IFNG Antibodies)-independent airway inflammation and AHR (show AHR Antibodies) post RSV infection in nude mice.
SARM1, Not MyD88 (show MYD88 Antibodies), Mediates TLR7 (show TLR7 Antibodies)/TLR9 (show TLR9 Antibodies)-Induced Apoptosis in Neurons
nicotinamide mononucleotide adenylyltransferase 2 (show NMNAT2 Antibodies)-depletion-dependent degeneration of established axons and restricted extension of developing axons are thus both SARM1 dependent
SARM1-induced depletion of NAD(+) may explain the potent axon protection in Wallerian degeneration slow (Wld(s)) mutant mice.
The findings suggest that Sarm1 regulates social behaviors and cognition.
Therefore, Sarm1 functions downstream of ROS (show ROS1 Antibodies) to induce neuronal cell death and axon degeneration during oxidative stress.
SARM expression was reduced and TRIF (show RNF138 Antibodies) expression was increased after respiratory syncytial virus infection.
this study identifies a new role for SARM in CCL5 (show CCL5 Antibodies) expression in macrophages.
Wild-type LPS (show TLR4 Antibodies) is able to upregulate SARM and to prevent SIRPalpha downregulation.
Active nerve degeneration requires SARM1 and MAP kinases, including DLK (show DAPK3 Antibodies), while the NAD+ synthetic enzyme NMNAT2 (show NMNAT2 Antibodies) prevents degeneration.
Data show that sterile alpha- and armadillo-motif-containing protein (SARM) modulates MyD88 protein-mediated Toll-like receptors (TLRs) activation through BB-loop dependent interleukin-1 receptor (TIR) TIR-TIR interactions.
These results indicate that association of PINK1 (show PINK1 Antibodies) with SARM1 and TRAF6 (show TRAF6 Antibodies) is an important step for mitophagy.
The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.
Rapid Wallerian degeneration requires the pro-degenerative molecules SARM1.
Data found that the UXT (show UXT Antibodies) isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis.
SARM overexpression caused mitochondrial clustering which has also been observed in several cell death phenomenon.
The N-terminal 27 amino acids (S27 (show RPS27 Antibodies)) of SARM, which is hydrophobic and polybasic, acts as a mitochondria-targeting signal sequence, associating SARM to the mitochondria. The S27 (show RPS27 Antibodies) peptide has an inherent ability to bind to lipids and mitochondria.
SARM-mediated inhibition may not be exclusively directed at TRIF (show TRIM69 Antibodies) or MyD88 (show MYD88 Antibodies), but that SARM may also directly inhibit MAPK (show MAPK1 Antibodies) phosphorylation
TIR adaptor SARM is a negative regulator of Toll (show TLR4 Antibodies)-like receptor signaling.
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88- dependent pathway or non-TLR signaling. Negative regulator of NF- kappa-B and IRF activation (By similarity).
sterile alpha and TIR motif-containing protein 1
, sterile alpha and TIR motif containing 1
, Tir-1 homolog
, SAM domain-containing protein 2
, sterile alpha and Armadillo repeat protein
, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
, sterile alpha motif domain-containing protein 2
, tir-1 homolog