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Browse our TAB2 Proteins (TAB2)

Full name:
TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 Proteins (TAB2)
On www.antibodies-online.com are 2 TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) Proteins from 1 different suppliers available. Additionally we are shipping TAB2 Antibodies (53) and TAB2 Kits (4) and many more products for this protein. A total of 65 TAB2 products are currently listed.
Synonyms:
1110030N06Rik, A530078N03Rik, CHTD2, map3k7ip2, mKIAA0733, zgc:77446
list all proteins Gene Name GeneID UniProt
TAB2 23118 Q9NYJ8
TAB2 68652 Q99K90
Rat TAB2 TAB2 308267 Q5U303

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TAB2 Proteins (TAB2) by Origin

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More Proteins for TAB2 Interaction Partners

Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) interaction partners

  1. DK1 inhibits the formation of the TAK1 (show MAP3K7 Proteins)-TAB2-TRAF6 (show TRAF6 Proteins) complex and leads to the inhibition of TRAF6 (show TRAF6 Proteins) ubiquitination.

  2. Authors demonstrate that enterovirus 71 3C interacts with TAB2 and TAK1 (show MAP3K7 Proteins) and suppresses cytokine expression via cleavage of the TAK1 (show MAP3K7 Proteins) complex proteins.

  3. SUMOylation may serve as a novel mechanism for the regulation of TAB2.

  4. conclude that TRIM38 (show TRIM38 Proteins) negatively regulates TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-induced signaling pathways

  5. These data indicate that overexpression of TRIM22 (show TRIM22 Proteins) may negatively regulate the TRAF6 (show TRAF6 Proteins)-stimulated NF-kappaB (show NFKB1 Proteins) pathway by interacting with and degrading TAB2.

  6. our data implicate Tab2 as a mediator of resistance to endocrine therapy and as a potential new target to reverse pharmacological resistance and potentiate antiestrogen action.

  7. We found that endothelial TAK1 (show MAP3K7 Proteins) and TAB2, but not TAB1 (show TAB1 Proteins), were critically involved in vascular formation

  8. MiR (show MLXIP Proteins)-23b suppresses IL-17 (show IL17A Proteins)-, tumor necrosis factor alpha (TNF-alpha (show TNF Proteins))- or IL-1beta (show IL1B Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation and inflammatory cytokine expression by targeting TAB2, TAB3 (show TAB3 Proteins) and IKK-alpha (show CHUK Proteins).

  9. TAK1 (show MAP3K7 Proteins) and its adapter protein (show TOLLIP Proteins), TAB2, reciprocally regulate both TAK1 (show MAP3K7 Proteins)- and ASK1 (show MAP3K5 Proteins)-mediated signaling pathways to direct the activations of NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins).

  10. human TAB2 and TAB3 (show TAB3 Proteins), ubiquitin-chain sensory proteins involved in NF-kappaB (show NFKB1 Proteins) signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB (show NFKB1 Proteins) signalling

Mouse (Murine) TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) interaction partners

  1. RNF4 (show RNF4 Proteins) negatively regulates NF-kappaB (show NFKB1 Proteins) signaling by down-regulating TAB2

  2. TAB1 (show TAB1 Proteins) and TAB2 are required for activated macrophages, making TAB1 (show TAB1 Proteins) and TAB2 effective targets to control inflammation by modulating macrophage survival.

  3. Loss of Tab2 is associated with liver injury.

  4. miR (show MLXIP Proteins)-155 inhibits the immunosuppressive capacity of MSCs by reducing iNOS (show NOS2 Proteins) expression by targeting TAB2.

  5. TAB2 and TAB3 (show TAB3 Proteins) are essential for B cell activation (show BLNK Proteins) leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.

  6. We found that endothelial TAK1 (show NR2C2 Proteins) and TAB2, but not TAB1 (show TAB1 Proteins), were critically involved in vascular formation

  7. MiR (show MLXIP Proteins)-23b suppresses IL-17 (show IL17A Proteins)-, tumor necrosis factor alpha (TNF-alpha (show TNF Proteins))- or IL-1beta (show IL1B Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation and inflammatory cytokine expression by targeting TAB2, TAB3 (show TAB3 Proteins) and IKK-alpha (show CHUK Proteins).

  8. Epithelial TAK1 (show NR2C2 Proteins) activity is regulated through two unique, TAB1 (show TAB1 Proteins)-dependent basal & TAB2-mediated stimuli-dependent mechanisms.

  9. TAK1 (show NR2C2 Proteins) and its adapter protein (show GRB10 Proteins), TAB2, reciprocally regulate both TAK1 (show NR2C2 Proteins)- and ASK1 (show MAP3K5 Proteins)-mediated signaling pathways to direct the activations of NF-kappaB (show NFKB1 Proteins) and AP-1 (show JUN Proteins).

  10. Wnt3a (show WNT3A Proteins) stimulation led to an increase in the interaction of TAB2 with NLK (show NLK Proteins) and the formation of a TAK1 (show NR2C2 Proteins).TAB2.NLK (show NLK Proteins) complex, suggesting that this TAK1 (show NR2C2 Proteins)-TAB2-NLK (show NLK Proteins) pathway may constitute a negative feedback mechanism for canonical Wnt (show WNT2 Proteins) signaling.

Zebrafish TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) interaction partners

  1. a critical, dosage-sensitive role during development was demonstrated by the cardiac defects observed upon titrated knockdown of tab2 expression in zebrafish embryos

TAB2 Protein Profile

Protein Summary

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

Alternative names and synonyms associated with TAB2

  • TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2)
  • TGF-beta activated kinase 1/MAP3K7 binding protein 2 (Tab2)
  • TGF-beta activated kinase 1/MAP3K7 binding protein 2 (tab2)
  • 1110030N06Rik protein
  • A530078N03Rik protein
  • CHTD2 protein
  • map3k7ip2 protein
  • mKIAA0733 protein
  • zgc:77446 protein

Protein level used designations for TAB2

TGF-beta activated kinase 1/MAP3K7 binding protein 2 , mitogen-activated protein kinase kinase kinase 7-interacting protein 2-like , TAB-2 , TAK1-binding protein 2 , TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 , TGF-beta-activated kinase 1-binding protein 2 , mitogen-activated protein kinase kinase kinase 7-interacting protein 2 , mitogen-activated protein kinase kinase kinase 7 interacting protein 2 , Tak1 binding protein 2 , mitogen activated protein kinase kinase kinase 7 interacting protein 2 , mitogen-activated protein kinase kinase kinase 7-interacting protein 2 homolog

GENE ID SPECIES
100026855 Monodelphis domestica
100414129 Callithrix jacchus
100597932 Nomascus leucogenys
23118 Homo sapiens
421622 Gallus gallus
484028 Canis lupus familiaris
540203 Bos taurus
68652 Mus musculus
308267 Rattus norvegicus
494163 Danio rerio
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