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Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells.
TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB (show NFKB1 Proteins) pathway.
Upregulation of miR (show MLXIP Proteins)-532-5p and subsequent suppression of the SESTD1 (show SESTD1 Proteins) and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection.
miR (show MLXIP Proteins)-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE
miR (show MLXIP Proteins)-26b suppresses NF-kappaB (show NFKB1 Proteins) signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 (show MAP3K7 Proteins) and TAB3.
conclude that TRIM38 (show TRIM38 Proteins) negatively regulates TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-induced signaling by mediating lysosome-dependent degradation of TAB2 (show TAB2 Proteins)/3, two critical components in TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-induced signaling pathways
Studies show that three proteins expressed in HEK (show EPHA3 Proteins)-293T cells (NAP1 (show IL8 Proteins), TANK and TBKBP1 (show TBKBP1 Proteins)) interact with TBK1 (show TBK1 Proteins).
MiR (show MLXIP Proteins)-23b suppresses IL-17 (show IL17A Proteins)-, tumor necrosis factor alpha (TNF-alpha (show TNF Proteins))- or IL-1beta (show IL1B Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation and inflammatory cytokine expression by targeting TAB2 (show TAB2 Proteins), TAB3 and IKK-alpha (show CHUK Proteins).
human TAB2 (show TAB2 Proteins) and TAB3, ubiquitin-chain sensory proteins involved in NF-kappaB (show NFKB1 Proteins) signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB (show NFKB1 Proteins) signalling
These results point to the existence of an autophagy-stimulatory 'switch' whereby TAB2 (show TAB2 Proteins) and TAB3 abandon inhibitory interactions with Beclin 1 (show BECN1 Proteins) to engage in a stimulatory liaison with TAK1 (show MAP3K7 Proteins).
Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease
TAB2 (show TAB2 Proteins) and TAB3 are essential for B cell activation (show BLNK Proteins) leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
TGF-beta activated kinase 1/MAP3K7 binding protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3-like
, NF-kappa-B-activating protein 1
, NFkB activating protein 1
, TAK1-binding protein 3
, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
, TGF-beta-activated kinase 1-binding protein 3
, mitogen-activated protein kinase kinase kinase 7 interacting protein 3
, mitogen activated protein kinase kinase kinase 7 interacting protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3