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The induction of antibodies to an AQP4 (show AQP4 ELISA Kits) epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 (show AQP4 ELISA Kits) antibodies in human neuromyelitis optica.
Antibiotics-induced 'germ free' status or the additional MyD88 (show MYD88 ELISA Kits) deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions
ABIN1 (show TNIP1 ELISA Kits) requires its ubiquitin binding domain and cooperates with TAX1BP1 and A20 (show TNFAIP3 ELISA Kits) to restrict antiviral signaling.
results demonstrate TBK1 (show TBK1 ELISA Kits)-IKKi (show IKBKE ELISA Kits) to be novel substrates for A20 (show TNFAIP3 ELISA Kits) and further identify a novel mechanism whereby A20 (show TNFAIP3 ELISA Kits) and TAX1BP1 restrict antiviral signaling by disrupting a TRAF3 (show TRAF3 ELISA Kits)-TBK1 (show TBK1 ELISA Kits)-IKKi (show IKBKE ELISA Kits) signaling complex
TAX1BP1 is pivotal for the termination of NF-kappaB (show NFKB1 ELISA Kits) and JNK (show MAPK8 ELISA Kits) signaling by functioning as an essential regulator of A20 (show TNFAIP3 ELISA Kits).
TAX1BP1 is an essential adaptor for linking A20 (show TNFAIP3 ELISA Kits) to TRAF6 (show TRAF6 ELISA Kits) and other factors in order to influence NF-B activation.
These results reveal the molecular mechanism of TIP-1 (show TAX1BP3 ELISA Kits) as an antagonist in PDZ domain (show INADL ELISA Kits) signaling.
we demonstrate that myosin VI (show MYO6 ELISA Kits) and TAX1BP1 are recruited to ubiquitylated Salmonella and play a key role in xenophagy
A protein construct corresponding to the SKICH domain plus the linker region was expressed, purified and crystallized for TAX1BP1.
RNF11 (show RNF11 ELISA Kits) functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta (show IFNB1 ELISA Kits) production.
Autophagy of Tax1bp1/Ndp52 (show CALCOCO2 ELISA Kits) promotes non-canonical NF-kappaB (show NFKB1 ELISA Kits) signalling.
Allele frequencies of three Alu insertions that are located in MEF2C (show MEF2C ELISA Kits) (two of them) and TAX1BP1 genes significantly differ between cohorts of healthy donors and ALL(acute lymphoblastic leukemia) patients.
In a link with T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis, an alphabeta T cell receptor recognizes a self peptide from neuronal protein (show LRCH1 ELISA Kits) HuD (show ELAVL4 ELISA Kits) in context of histocompatibility antigen HLA-A2.
There is evidence of the association between the TAX1BP1 polymorphism and oral cavity cancer but there are no differences in the distribution of the polymorphism among patients with head and neck cancer and individuals without history of neoplasm.
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tax1 (human T-cell leukemia virus type I) binding protein 1
, tax1-binding protein 1 homolog B
, Tax1 binding protein 1
, muscle-derived protein 62
, TRAF6-binding protein homolog
, tax1-binding protein 1 homolog
, TRAF6-binding protein
, tax1-binding protein 1
, liver regeneration-related protein 2
, liver regeneration-related protein LRRG004