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Cow (Bovine) Monoclonal TBK1 Primary Antibody for ICC, IF - ABIN252648
Merimi, Klener, Szynal, Cleuter, Kerkhofs, Burny, Martiat, Van den Broeke: Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. in Journal of virology 2007
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Human Monoclonal TBK1 Primary Antibody for WB - ABIN967614
Kishore, Huynh, Mathialagan, Hall, Rouw, Creely, Lange, Caroll, Reitz, Donnelly, Boddupalli, Combs, Kretzmer, Tripp: IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Human Polyclonal TBK1 Primary Antibody for ICC, ELISA - ABIN1002907
Pomerantz, Baltimore: NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. in The EMBO journal 2000
Show all 2 Pubmed References
Human Monoclonal TBK1 Primary Antibody for ICS - ABIN1176943
Viatour, Merville, Bours, Chariot: Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. in Trends in biochemical sciences 2005
Human Polyclonal TBK1 Primary Antibody for WB - ABIN151881
Xie, Zhang, Zhao, Lu, You, Condorelli, Wang, Guan: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2011
Fish IRF6 (show IRF6 Antibodies) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Antibodies) and TBK1, suggesting that differences in the IRF6 (show IRF6 Antibodies) regulation pattern exist between lower and higher vertebrates.
Our results highlight an unexpected role of the Golgi apparatus in innate immunity as a key subcellular gateway for TBK1 activation after RNA virus infection.
The results of this study proposed that TBK1 is not a frequent causal gene in Chinese ALS patients.
HERP (show HERPUD1 Antibodies) Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 and thereby hinders the association of TBK1 with its substrate IRF3 (show IRF3 Antibodies), thus blocking IRF3 (show IRF3 Antibodies) activation and transcriptional induction of the cellular antiviral responses.
Pathogenic variants in TBK1 are rare but could be responsible for sALS (show CDH23 Antibodies) in a small number of Korean patients.
High TBK1 expression is associated with normal tension glaucoma.
We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).
Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (show IGFALS Antibodies)) with or without comorbid frontotemporal dementia.
The occurrence of TBK1 mutations in FTD (show FTL Antibodies) and ALS (show IGFALS Antibodies) underlines the fact that FTD (show FTL Antibodies) and ALS (show IGFALS Antibodies) are part of the same disease spectrum. For future therapeutic trials, characterization of TBK1 mutation carriers in presymptomatic cohorts, such as the genetic frontotemporal dementia initiative (GENFI), is of great importance.
demonstrate a key role of TBK1/IKKepsilon (show IKBKE Antibodies) in the survival and proliferation of HTLV-1-transformed T cells
these studies reveal an additional regulatory function of TRIM8 (show TRIM8 Antibodies) in innate immune responses: TRIM8 (show TRIM8 Antibodies) catalyzes polyubiquitination of TRIF (show RNF138 Antibodies), resulting in disruption of TRIF (show RNF138 Antibodies)-TBK1 interaction
TBK1 regulates p16 (show CDKN2A Antibodies) expression and retinal ganglion cell senescence.
USP38 inhibits type I interferon (show IFNA Antibodies) signaling by editing TBK1 ubiquitination through NLRP4 signalosome.
The authors report that Raf kinase inhibitory protein (RKIP (show PEBP1 Antibodies)) is essential for TBK1 activation and type I interferon (show IFNA Antibodies) production triggered by viral infection.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Antibodies) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Antibodies)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Antibodies) (TRIF (show RNF138 Antibodies)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Antibodies) and TRIF (show RNF138 Antibodies).
TBK1 complexes required for the phosphorylation of IRF3 (show IRF3 Antibodies) and the production of interferon-beta (show IFNB1 Antibodies) have been identified.
this study reveals a previously unknown ICOS (show ICOS Antibodies)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells
Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver
Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Antibodies))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Antibodies)).
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
serine/threonine-protein kinase TBK1
, TANK-binding kinase 1
, NF-kappa-B-activating kinase
, TANK binding kinase 1
, serine/threonine protein kinase TBK1
, serine/threonine-protein kinase TBK1-like
, NF-kB-activating kinase