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Browse our TANK-Binding Kinase 1 Proteins (TBK1)

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TANK-Binding Kinase 1 Proteins (TBK1)
On are 9 TANK-Binding Kinase 1 (TBK1) Proteins from 7 different suppliers available. Additionally we are shipping TANK-Binding Kinase 1 Antibodies (155) and TANK-Binding Kinase 1 Kits (12) and many more products for this protein. A total of 186 TANK-Binding Kinase 1 products are currently listed.
1200008B05Rik, AI462036, AW048562, NAK, T2K, TBK1, wu:fk70c05, zgc:136548
list all proteins Gene Name GeneID UniProt
TBK1 29110 Q9UHD2
TBK1 56480 Q9WUN2
TBK1 299827  

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TANK-Binding Kinase 1 Proteins (TBK1) by Origin

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More Proteins for TANK-Binding Kinase 1 Interaction Partners

Zebrafish TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Fish IRF6 (show IRF6 Proteins) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Proteins) and TBK1, suggesting that differences in the IRF6 (show IRF6 Proteins) regulation pattern exist between lower and higher vertebrates.

Human TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon (show IKBKE Proteins)) and TANK-binding kinase 1 (TBK1) expression may be involved in the development of intestinal-type gastric cancer.

  2. Here the authors show that recruitment of WIPI2 (show WIPI2 Proteins), itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria.

  3. review of the role of TBK1 in the seemingly unrelated, yet allelic diseases amyotrophic lateral sclerosis (ALS (show IGFALS Proteins)), frontotemporal dementia (FTD (show FTL Proteins)), normal tension glaucoma (NTG (show OPA1 Proteins)) and childhood herpes simplex encephalitis and discuss the role of TBK1 in neuroinflammatory diseases

  4. Enrichment of qualifying variants toward glaucoma was present in all genes except WDR36 (show WDR36 Proteins), in which controls harbored more variants, and TBK1, in which no qualifying variants were detected in cases or controls.

  5. Human herpesvirus 1 ICP27 interacted with TBK1 and STING in a manner that was dependent on TBK1 activity and the RGG motif in ICP27 and inhibited type I IFN induction through the cGAS-STING-TBK1 pathway in human macrophages.

  6. Upon cytosolic DNA stimulation, STAT3 (show STAT3 Proteins) Ser (show SIGLEC1 Proteins)(754) is directly phosphorylated by TBK1 in a STING-dependent manner. Moreover, Ser (show SIGLEC1 Proteins)(754) phosphorylation inhibits cytosolic DNA-induced STAT3 (show STAT3 Proteins) transcriptional activity and selectively reduces STAT3 (show STAT3 Proteins) target genes that are up-regulated in response to cytosolic DNA

  7. YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) act as natural inhibitors of TBK1 and are vital for antiviral physiology.

  8. TBK1 complexes required for the phosphorylation of IRF3 (show IRF3 Proteins) and the production of interferon-beta (show IFNB1 Proteins) have been identified.

  9. This review suggested that haploinsufficiency of TBK1 is causative for ALS (show IGFALS Proteins) and FTD (show FTL Proteins) regardless of the type of mutation.

  10. Report establishes optineurin (show OPTN Proteins) as a positive regulator TBK1 via a bipartite interaction between these molecules.

Mouse (Murine) TANK-Binding Kinase 1 (TBK1) interaction partners

  1. The authors report that Raf kinase inhibitory protein (RKIP (show PEBP1 Proteins)) is essential for TBK1 activation and type I interferon (show IFNA Proteins) production triggered by viral infection.

  2. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Proteins) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Proteins)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Proteins) and TRIF (show RNF138 Proteins).

  3. TBK1 complexes required for the phosphorylation of IRF3 (show IRF3 Proteins) and the production of interferon-beta (show IFNB1 Proteins) have been identified.

  4. this study reveals a previously unknown ICOS (show ICOS Proteins)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells

  5. Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver

  6. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Proteins))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Proteins)).

  7. This study suggest that TBK1 exerts pronociceptive effects in inflammatory nociception which are due to both modulation of NF-kappaB dependent genes and regulation of MAPKs and c-fos.

  8. TRIM27 (show RFP Proteins) inhibits VSV infection-induced type I IFN production by promoting TBK1 degradation.

  9. Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon (show IKBKE Proteins) and TBK1 may contribute to the repression of energy expenditure during obesity.

  10. TBK1 has a role in regulating T-cell activation and migration

TANK-Binding Kinase 1 (TBK1) Protein Profile

Protein Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Alternative names and synonyms associated with TANK-Binding Kinase 1 (TBK1)

  • TANK-binding kinase 1 (tbk1)
  • TANK-binding kinase 1 (TBK1)
  • TANK-binding kinase 1 (LOC100358771)
  • TANK-binding kinase 1 (Tbk1)
  • 1200008B05Rik protein
  • AI462036 protein
  • AW048562 protein
  • NAK protein
  • T2K protein
  • TBK1 protein
  • wu:fk70c05 protein
  • zgc:136548 protein

Protein level used designations for TANK-Binding Kinase 1 Proteins (TBK1)

serine/threonine-protein kinase TBK1 , TANK-binding kinase 1 , NF-kappa-B-activating kinase , TANK binding kinase 1 , serine/threonine protein kinase TBK1 , serine/threonine-protein kinase TBK1-like , NF-kB-activating kinase , T2K

446351 Xenopus laevis
452047 Pan troglodytes
692289 Danio rerio
717427 Macaca mulatta
100051650 Equus caballus
100125828 Sus scrofa
100216212 Xenopus (Silurana) tropicalis
100358771 Oryctolagus cuniculus
100399701 Callithrix jacchus
100433568 Pongo abelii
100484104 Ailuropoda melanoleuca
100553575 Anolis carolinensis
100582856 Nomascus leucogenys
29110 Homo sapiens
481145 Canis lupus familiaris
533141 Bos taurus
56480 Mus musculus
299827 Rattus norvegicus
417825 Gallus gallus
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