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Browse our TANK-Binding Kinase 1 Proteins (TBK1)

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TANK-Binding Kinase 1 Proteins (TBK1)
On are 8 TANK-Binding Kinase 1 (TBK1) Proteins from 6 different suppliers available. Additionally we are shipping TANK-Binding Kinase 1 Antibodies (160) and TANK-Binding Kinase 1 Kits (10) and many more products for this protein. A total of 188 TANK-Binding Kinase 1 products are currently listed.
1200008B05Rik, AI462036, AW048562, NAK, T2K, TBK1, wu:fk70c05, zgc:136548
list all proteins Gene Name GeneID UniProt
TBK1 29110 Q9UHD2
TBK1 56480 Q9WUN2
TBK1 299827  

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TANK-Binding Kinase 1 Proteins (TBK1) by Origin

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More Proteins for TANK-Binding Kinase 1 Interaction Partners

Zebrafish TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Fish IRF6 (show IRF6 Proteins) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Proteins) and TBK1, suggesting that differences in the IRF6 (show IRF6 Proteins) regulation pattern exist between lower and higher vertebrates.

Human TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Report establishes optineurin (show OPTN Proteins) as a positive regulator TBK1 via a bipartite interaction between these molecules.

  2. TBK1 duplication is found in normal tension and not in high tension open-angle glaucoma patients of Indian origin.

  3. A broader phenotypic range may be associated with TBK1 copy-number variations, although mutations in this gene are most often detected in patients with normal-tension glaucoma.

  4. Autoubiquitination of TRIM26 (show TRIM26 Proteins) links TBK1 to NEMO (show IKBKG Proteins) in RLR (show DHX58 Proteins)-mediated innate antiviral immune response

  5. ALS (show IGFALS Proteins)-linked mutations in OPTN (show OPTN Proteins) and TBK1 can interfere with mitophagy, suggesting that inefficient turnover of damaged mitochondria may represent a key pathophysiological mechanism contributing to neurodegenerative disease.

  6. Mutations in the TBK1 gene were identified to cause amyotrophic lateral sclerosis (ALS)

  7. In combination with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and retention of OPTN (show OPTN Proteins)/TBK1 on ubiquitinated, damaged mitochondria

  8. TBK1 should thus also be sequenced, after exclusion of C9orf72 (show C9ORF72 Proteins) mutation, in patients presenting frontotemporal dementia, particularly in cases secondarily associated with amyotrophic lateral sclerosis

  9. TBK1 carriers with amyotrophic lateral sclerosis had shorter disease duration than carriers with frontotemporal dementia in a Belgian cohort.

  10. The expression of TBK1 in mammalian cell mitosis is reported, including localization of the protein during division and its binding properties.

Mouse (Murine) TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver

  2. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Proteins))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Proteins)).

  3. This study suggest that TBK1 exerts pronociceptive effects in inflammatory nociception which are due to both modulation of NF-kappaB dependent genes and regulation of MAPKs and c-fos.

  4. TRIM27 (show RFP Proteins) inhibits VSV infection-induced type I IFN production by promoting TBK1 degradation.

  5. Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon (show IKBKE Proteins) and TBK1 may contribute to the repression of energy expenditure during obesity.

  6. TBK1 has a role in regulating T-cell activation and migration

  7. findings demonstrate a novel regulatory circuit in which STING and TBK1 reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A (show PPM1A Proteins) dephosphorylates STING and TBK1

  8. our results identify CK2 (show CSNK2A1 Proteins) as a novel regulator of TBK1 and IRF3 (show IRF3 Proteins) and suggest that targeting CK2 (show CSNK2A1 Proteins) by small molecular inhibitor may be a viable approach to prevent and treat viral infections.

  9. A role for APPL1 (show APPL1 Proteins) in TLR3 (show TLR3 Proteins)/4-dependent TBK1 and IKKepsilon (show IKBKE Proteins) activation in macrophages.

  10. The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon (show IKBKE Proteins) in innate immune response.Interestingly, corresponding region and residues are not required for activation of downstream signaling by TBK1.

TANK-Binding Kinase 1 (TBK1) Protein Profile

Protein Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Alternative names and synonyms associated with TANK-Binding Kinase 1 (TBK1)

  • TANK-binding kinase 1 (tbk1)
  • TANK-binding kinase 1 (TBK1)
  • TANK-binding kinase 1 (LOC100358771)
  • TANK-binding kinase 1 (Tbk1)
  • 1200008B05Rik protein
  • AI462036 protein
  • AW048562 protein
  • NAK protein
  • T2K protein
  • TBK1 protein
  • wu:fk70c05 protein
  • zgc:136548 protein

Protein level used designations for TANK-Binding Kinase 1 Proteins (TBK1)

serine/threonine-protein kinase TBK1 , TANK-binding kinase 1 , NF-kappa-B-activating kinase , TANK binding kinase 1 , serine/threonine protein kinase TBK1 , serine/threonine-protein kinase TBK1-like , NF-kB-activating kinase , T2K

446351 Xenopus laevis
452047 Pan troglodytes
692289 Danio rerio
717427 Macaca mulatta
100051650 Equus caballus
100125828 Sus scrofa
100216212 Xenopus (Silurana) tropicalis
100358771 Oryctolagus cuniculus
100399701 Callithrix jacchus
100433568 Pongo abelii
100484104 Ailuropoda melanoleuca
100553575 Anolis carolinensis
100582856 Nomascus leucogenys
29110 Homo sapiens
481145 Canis lupus familiaris
533141 Bos taurus
56480 Mus musculus
299827 Rattus norvegicus
417825 Gallus gallus
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