Browse our TANK-Binding Kinase 1 Proteins (TBK1)

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TANK-Binding Kinase 1 Proteins (TBK1)
On www.antibodies-online.com are 11 TANK-Binding Kinase 1 (TBK1) Proteins from 7 different suppliers available. Additionally we are shipping TANK-Binding Kinase 1 Antibodies (156) and TANK-Binding Kinase 1 Kits (15) and many more products for this protein. A total of 192 TANK-Binding Kinase 1 products are currently listed.
Synonyms:
1200008B05Rik, AI462036, AW048562, NAK, T2K, TBK1, wu:fk70c05, zgc:136548
list all proteins Gene Name GeneID UniProt
TBK1 29110 Q9UHD2
TBK1 56480 Q9WUN2
TBK1 299827  

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TANK-Binding Kinase 1 Proteins (TBK1) by Origin

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More Proteins for TANK-Binding Kinase 1 Interaction Partners

Zebrafish TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Fish IRF6 (show IRF6 Proteins) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Proteins) and TBK1, suggesting that differences in the IRF6 (show IRF6 Proteins) regulation pattern exist between lower and higher vertebrates.

Human TANK-Binding Kinase 1 (TBK1) interaction partners

  1. High TBK1 expression is associated with normal tension glaucoma.

  2. We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).

  3. Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (show IGFALS Proteins)) with or without comorbid frontotemporal dementia.

  4. The occurrence of TBK1 mutations in FTD (show FTL Proteins) and ALS (show IGFALS Proteins) underlines the fact that FTD (show FTL Proteins) and ALS (show IGFALS Proteins) are part of the same disease spectrum. For future therapeutic trials, characterization of TBK1 mutation carriers in presymptomatic cohorts, such as the genetic frontotemporal dementia initiative (GENFI), is of great importance.

  5. demonstrate a key role of TBK1/IKKepsilon (show IKBKE Proteins) in the survival and proliferation of HTLV-1-transformed T cells

  6. Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1-IKKepsilon (show IKBKE Proteins)-IRF3 (show IRF3 Proteins) complex, resulting in reduction in IRF3 (show IRF3 Proteins) phosphorylation and type I interferon (show IFNA Proteins) production. (TANK = TRAF family member associated NFKB activator (show TANK Proteins); TBK1 = TANK binding kinase 1; IKKepsilon (show IKBKE Proteins) = inhibitor of nuclear factor kappa B kinase subunit epsilon (show IKBKE Proteins); IRF3 (show IRF3 Proteins) = interferon regulatory factor 3 (show IRF3 Proteins))

  7. Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon (show IKBKE Proteins)) and TANK-binding kinase 1 (TBK1) expression may be involved in the development of intestinal-type gastric cancer.

  8. Here the authors show that recruitment of WIPI2 (show WIPI2 Proteins), itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria.

  9. review of the role of TBK1 in the seemingly unrelated, yet allelic diseases amyotrophic lateral sclerosis (ALS (show IGFALS Proteins)), frontotemporal dementia (FTD (show FTL Proteins)), normal tension glaucoma (NTG (show OPA1 Proteins)) and childhood herpes simplex encephalitis and discuss the role of TBK1 in neuroinflammatory diseases

  10. Enrichment of qualifying variants toward glaucoma was present in all genes except WDR36 (show WDR36 Proteins), in which controls harbored more variants, and TBK1, in which no qualifying variants were detected in cases or controls.

Mouse (Murine) TANK-Binding Kinase 1 (TBK1) interaction partners

  1. these studies reveal an additional regulatory function of TRIM8 (show TRIM8 Proteins) in innate immune responses: TRIM8 (show TRIM8 Proteins) catalyzes polyubiquitination of TRIF (show RNF138 Proteins), resulting in disruption of TRIF (show RNF138 Proteins)-TBK1 interaction

  2. TBK1 regulates p16 expression and retinal ganglion cell senescence.

  3. USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome.

  4. The authors report that Raf kinase inhibitory protein (RKIP (show PEBP1 Proteins)) is essential for TBK1 activation and type I interferon (show IFNA Proteins) production triggered by viral infection.

  5. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Proteins) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Proteins)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Proteins) and TRIF (show RNF138 Proteins).

  6. TBK1 complexes required for the phosphorylation of IRF3 (show IRF3 Proteins) and the production of interferon-beta (show IFNB1 Proteins) have been identified.

  7. this study reveals a previously unknown ICOS (show ICOS Proteins)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells

  8. Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver

  9. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (show RPS6KB1 Proteins))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (show IRF3 Proteins)).

  10. This study suggest that TBK1 exerts pronociceptive effects in inflammatory nociception which are due to both modulation of NF-kappaB dependent genes and regulation of MAPKs and c-fos.

TANK-Binding Kinase 1 (TBK1) Protein Profile

Protein Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Alternative names and synonyms associated with TANK-Binding Kinase 1 (TBK1)

  • TANK-binding kinase 1 (tbk1)
  • TANK-binding kinase 1 (TBK1)
  • TANK-binding kinase 1 (LOC100358771)
  • TANK-binding kinase 1 (Tbk1)
  • 1200008B05Rik protein
  • AI462036 protein
  • AW048562 protein
  • NAK protein
  • T2K protein
  • TBK1 protein
  • wu:fk70c05 protein
  • zgc:136548 protein

Protein level used designations for TANK-Binding Kinase 1 Proteins (TBK1)

serine/threonine-protein kinase TBK1 , TANK-binding kinase 1 , NF-kappa-B-activating kinase , TANK binding kinase 1 , serine/threonine protein kinase TBK1 , serine/threonine-protein kinase TBK1-like , NF-kB-activating kinase , T2K

GENE ID SPECIES
446351 Xenopus laevis
452047 Pan troglodytes
692289 Danio rerio
717427 Macaca mulatta
100051650 Equus caballus
100125828 Sus scrofa
100216212 Xenopus (Silurana) tropicalis
100358771 Oryctolagus cuniculus
100399701 Callithrix jacchus
100433568 Pongo abelii
100484104 Ailuropoda melanoleuca
100553575 Anolis carolinensis
100582856 Nomascus leucogenys
29110 Homo sapiens
481145 Canis lupus familiaris
533141 Bos taurus
56480 Mus musculus
299827 Rattus norvegicus
417825 Gallus gallus
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