Browse our TICAM1 Proteins (TICAM1)

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Toll-Like Receptor Adaptor Molecule 1 Proteins (TICAM1)
On are 5 Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Proteins from 3 different suppliers available. Additionally we are shipping TICAM1 Antibodies (82) and TICAM1 Kits (7) and many more products for this protein. A total of 100 TICAM1 products are currently listed.
AW046014, AW547018, IIAE6, MyD88-3, PRVTIRB, TICAM-1, trif
list all proteins Gene Name GeneID UniProt
TICAM1 148022 Q8IUC6
TICAM1 106759 Q80UF7
Rat TICAM1 TICAM1 363328  

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TICAM1 Proteins (TICAM1) by Origin

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More Proteins for TICAM1 Interaction Partners

Human Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. Therefore, Seneca Valley virus suppressed antiviral interferon (show IFNA Proteins) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (show MAVS Proteins), TRIF (show TRIM69 Proteins), and TANK by its 3C protease.

  2. TRIF (show TRIM69 Proteins) gene may contribute to susceptibility of T2DM.

  3. The NF-kappaB (show NFKB1 Proteins) activated by dsRNA appears not to be the canonical p65 (show GORASP1 Proteins)/p50 (show CD40 Proteins) heterodimers.

  4. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (show FOXE1 Proteins)/HEMGN, SERPINA5 (show SERPINA5 Proteins) (rs2069974), FTO (show FTO Proteins) (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (show SCARB1 Proteins) (rs11057820) genes. We found associations with SNPs in FOXE1 (show FOXE1 Proteins), SERPINA5 (show SERPINA5 Proteins), FTO (show FTO Proteins), TICAM1 and HSPA6 (show HSPA6 Proteins) and and follicular thyroid cancer

  5. IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF (show TRIM69 Proteins).

  6. TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT (show CHPT1 Proteins)-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line

  7. involved in signaling that moderates the expression of heme oxygenase1 and il-8 (show IL8 Proteins) after keratinocytes exposure to dinitrochlorobenzene

  8. Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (show DEFB103A Proteins) suppresses the polyI:C-induced TLR3 (show TLR3 Proteins) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (show IFIH1 Proteins)) and MAVS (IPS1/CARDIF (show MAVS Proteins)).

  9. signaling through TRIF (show TRIM69 Proteins) is important for the inflammatory response of AngII-induced abdominal aortic aneurysm formation

  10. Data show that toll-like receptor 3 (show TLR3 Proteins)/TRIF (show TRIM69 Proteins) protein signalling regulates cytokines IL-32 (show IL32 Proteins) and IFN-beta (show IFNB1 Proteins) secretion by activation of receptor-interacting protein-1 (RIP-1 (show RIPK1 Proteins)) and tumour necrosis factor (show TNF Proteins) receptor-associated factor 6 (TRAF6 (show TRAF6 Proteins)) in cornea epithelial cells.

Mouse (Murine) Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA (show PCNA Proteins)- and ATM (show ATM Proteins)/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.

  2. Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (show NCAM1 Proteins) expression are regulated by both the MyD88 (show MYD88 Proteins)- and TRIF (show RNF138 Proteins)-dependent pathways.

  3. TRIF (show RNF138 Proteins) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.

  4. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Proteins) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Proteins)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)), and Tank-binding kinase 1 (TBK1 (show TBK1 Proteins)) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Proteins) and TRIF (show RNF138 Proteins).

  5. These results suggested the importance of TRIF (show RNF138 Proteins) in TLR2 mediated foam cell formation via inflammatory mediators, including MCP-1 (show CPT1B Proteins).

  6. DENV replication and IFNalpha/beta, TNF-alpha (show TNF Proteins), IL-12 (show IL12A Proteins) and IL-18 (show IL18 Proteins) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (show RNF138 Proteins), MYD88 (show MYD88 Proteins) or NF-kB inhibition

  7. The authors demonstrate that, in addition to MyD88 (show MYD88 Proteins), Yersinia pseudotuberculosis inhibits TRIF (show RNF138 Proteins) signaling through the type III secretion system effector YopJ.

  8. Results show that toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) domain-containing adaptor inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)) is essential for Toll (show TLR4 Proteins)-like receptors TLR3 (show TLR3 Proteins)- and TLR4 (show TLR4 Proteins)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).

  9. Data show that annexin A2 (AnxA2 (show ANXA2 Proteins)) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4 (show TLR4 Proteins))-initiated TRAM protein (show TRAM2 Proteins)-TRIF (show RNF138 Proteins) protein pathway occurring on endosomes.

  10. ProTalpha preconditioning-induced prevention of retinal ischemic damage is mediated by selective activation of the TIR-domain-containing adapter-inducing interferon-beta (show IFNB1 Proteins) interferon regulatory factor 3 (show IRF3 Proteins) pathway downstream of toll-like receptor 4 (show TLR4 Proteins) in microglia

Cow (Bovine) Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. Inhibition of the Toll (show TLR4 Proteins)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (show IFNB1 Proteins) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.

Zebrafish Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. 3D-models of rohu TLR3 (show TLR3 Proteins)-TIR and zebrafish TRIF

  2. The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (show NFKB1 Proteins) and zebrafish type I IFN was described.

  3. study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (show NFKB1 Proteins) response promoter

TICAM1 Protein Profile

Protein Summary

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.

Alternative names and synonyms associated with TICAM1

  • toll-like receptor adaptor molecule 1 (TICAM1)
  • toll-like receptor adaptor molecule 1 (LOC100231928)
  • toll-like receptor adaptor molecule 1 (Ticam1)
  • toll-like receptor adaptor molecule 1 (ticam1)
  • AW046014 protein
  • AW547018 protein
  • IIAE6 protein
  • MyD88-3 protein
  • PRVTIRB protein
  • TICAM-1 protein
  • trif protein

Protein level used designations for TICAM1

TIR domain-containing adapter molecule 1 , TIR domain containing adaptor inducing interferon-beta , toll-interleukin I receptor domain containing adaptor molecule 1 , toll-like receptor adaptor molecule 1 , TIR domain-containing adapter molecule 1-like , TIR domain-containing adapter protein inducing IFN-beta , proline-rich, vinculin and TIR domain-containing protein B , putative NF-kappa-B-activating protein 502H , toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta , TIR domain-containing adaptor inducing interferon-beta , toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta , TICAM-1 , TIR-domain containing adaptor inducing IFN-beta , TRIF/TICAM1

468677 Pan troglodytes
574294 Macaca mulatta
611852 Canis lupus familiaris
100062414 Equus caballus
100231928 Taeniopygia guttata
100405343 Callithrix jacchus
100588929 Nomascus leucogenys
148022 Homo sapiens
106759 Mus musculus
510427 Bos taurus
363328 Rattus norvegicus
403147 Danio rerio
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