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Browse our TICAM1 Proteins (TICAM1)

Full name:
Toll-Like Receptor Adaptor Molecule 1 Proteins (TICAM1)
On are 3 Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Proteins from 2 different suppliers available. Additionally we are shipping TICAM1 Antibodies (76) and TICAM1 Kits (6) and many more products for this protein. A total of 91 TICAM1 products are currently listed.
AW046014, AW547018, IIAE6, MyD88-3, PRVTIRB, TICAM-1, trif
list all proteins Gene Name GeneID UniProt
TICAM1 148022 Q8IUC6
TICAM1 106759 Q80UF7
Rat TICAM1 TICAM1 363328  

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TICAM1 Proteins (TICAM1) by Origin

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More Proteins for TICAM1 Interaction Partners

Human Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. involved in signaling that moderates the expression of heme oxygenase1 and il-8 (show IL8 Proteins) after keratinocytes exposure to dinitrochlorobenzene

  2. Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (show DEFB103A Proteins) suppresses the polyI:C-induced TLR3 (show TLR3 Proteins) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (show IFIH1 Proteins)) and MAVS (IPS1/CARDIF (show MAVS Proteins)).

  3. signaling through TRIF (show TRIM69 Proteins) is important for the inflammatory response of AngII-induced abdominal aortic aneurysm formation

  4. Data show that toll-like receptor 3 (show TLR3 Proteins)/TRIF (show TRIM69 Proteins) protein signalling regulates cytokines IL-32 (show IL32 Proteins) and IFN-beta (show IFNB1 Proteins) secretion by activation of receptor-interacting protein-1 (RIP-1 (show RIPK1 Proteins)) and tumour necrosis factor (show TNF Proteins) receptor-associated factor 6 (TRAF6 (show TRAF6 Proteins)) in cornea epithelial cells.

  5. WDFY1 (show WDFY1 Proteins) mediates TLR3 (show TLR3 Proteins)/TLR4 (show TLR4 Proteins) signaling by recruiting TRIF (show TRIM69 Proteins).

  6. In mic (show AGT Proteins)e with nonfunctional TRIF (Trif(mut) mice), Ang II-induced hypertension and cardiac hypertrophy were abrogated, and proinflammatory gene expression in heart and kid (show TRIM69 Proteins)neys was unchanged or decreased. These results indicate that Ang II induces activation of a proinflammatory innate immune response, causing hypertension and cardiac hypertrophy, which require functional adaptor protein TRIF-mediated pathways.

  7. TRIF (show TRIM69 Proteins) promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis.

  8. amino-terminal 21 amino acid sequence is crucial for TRAF3 (show TRAF3 Proteins) association, protein stability and activation of the IFN pathway

  9. required, in combination with MyD88 (show MYD88 Proteins), for TLR4 (show TLR4 Proteins)-mediated proinflammatory dendritic cell differentiation

  10. findings show that TRIF (show TRIM69 Proteins) activates IRF3 (show IRF3 Proteins) through a phosphorylation-dependent mechanism; results reveal that phosphorylation of innate adaptor proteins is an essential and conserved mechanism that selectively recruits IRF3 (show IRF3 Proteins) to activate the type I IFN pathway

Mouse (Murine) Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. Results show that toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) domain-containing adaptor inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)) is essential for Toll (show TLR4 Proteins)-like receptors TLR3 (show TLR3 Proteins)- and TLR4 (show TLR4 Proteins)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).

  2. Data show that annexin A2 (AnxA2 (show ANXA2 Proteins)) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4 (show TLR4 Proteins))-initiated TRAM protein (show TRAM2 Proteins)-TRIF (show RNF138 Proteins) protein pathway occurring on endosomes.

  3. ProTalpha preconditioning-induced prevention of retinal ischemic damage is mediated by selective activation of the TIR-domain-containing adapter-inducing interferon-beta (show IFNB1 Proteins) interferon regulatory factor 3 (show IRF3 Proteins) pathway downstream of toll-like receptor 4 (show TLR4 Proteins) in microglia

  4. signaling through TRIF (show RNF138 Proteins) is important for the inflammatory response of AngII-induced abdominal aortic aneurysm formation

  5. analysis of how MyD88 (show MYD88 Proteins) and TRIF (show RNF138 Proteins) affect TLR4 (show TLR4 Proteins) activation

  6. Ang II (show AGT Proteins) induces activation of a proinflammatory innate immune response, causing hypertension and cardiac hypertrophy. These effects require functional adaptor protein TRIF (show RNF138 Proteins)-mediated pathways.

  7. Data indicate that Toll-like receptor 4 (TLR4 (show TLR4 Proteins)) endocytosis and the TIR-domain-containing adapter-inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins))-signaling pathway in macrophages during endotoxin tolerance in the absence of cluster of differentiation 14 (CD14 (show CD14 Proteins)).

  8. A MAVS (show MAVS Proteins)/TICAM-1-independent interferon (show IFNA Proteins)-inducing pathway contributes to regulation of hepatitis B virus replication

  9. Trif was mainly present in the ganglion cell layer(GCL)after ischemia-reperfusion (IR) injury. Retinas of TrifKO mice had a significantly reduced neurotoxic pro-inflammatory response and significantly increased survival of the GCL neurons after IR.

  10. Mice with single or double deficiencies in these MyD88 (show MYD88 Proteins) and TRIF (show RNF138 Proteins) had reduced responses, based on finding fewer GFPhi Retinal dendritic cell in injured retinas post-optic nerve crush injury.

Cow (Bovine) Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. Inhibition of the Toll (show TLR4 Proteins)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (show IFNB1 Proteins) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.

Zebrafish Toll-Like Receptor Adaptor Molecule 1 (TICAM1) interaction partners

  1. 3D-models of rohu TLR3 (show TLR3 Proteins)-TIR and zebrafish TRIF

  2. The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (show NFKB1 Proteins) and zebrafish type I IFN was described.

  3. study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (show NFKB1 Proteins) response promoter

TICAM1 Protein Profile

Protein Summary

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.

Alternative names and synonyms associated with TICAM1

  • toll-like receptor adaptor molecule 1 (TICAM1)
  • toll-like receptor adaptor molecule 1 (LOC100231928)
  • toll-like receptor adaptor molecule 1 (Ticam1)
  • toll-like receptor adaptor molecule 1 (ticam1)
  • AW046014 protein
  • AW547018 protein
  • IIAE6 protein
  • MyD88-3 protein
  • PRVTIRB protein
  • TICAM-1 protein
  • trif protein

Protein level used designations for TICAM1

TIR domain-containing adapter molecule 1 , TIR domain containing adaptor inducing interferon-beta , toll-interleukin I receptor domain containing adaptor molecule 1 , toll-like receptor adaptor molecule 1 , TIR domain-containing adapter molecule 1-like , TIR domain-containing adapter protein inducing IFN-beta , proline-rich, vinculin and TIR domain-containing protein B , putative NF-kappa-B-activating protein 502H , toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta , TIR domain-containing adaptor inducing interferon-beta , toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta , TICAM-1 , TIR-domain containing adaptor inducing IFN-beta , TRIF/TICAM1

468677 Pan troglodytes
574294 Macaca mulatta
611852 Canis lupus familiaris
100062414 Equus caballus
100231928 Taeniopygia guttata
100405343 Callithrix jacchus
100588929 Nomascus leucogenys
148022 Homo sapiens
106759 Mus musculus
510427 Bos taurus
363328 Rattus norvegicus
403147 Danio rerio
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