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Data suggest that endosomal localization of TICAM2 (show TICAM2 Proteins) is essential for TLR4 (show TLR4 Proteins)-mediated type I interferon (show IFNA Proteins)-inducing signaling from endosomes; TICAM2 (show TICAM2 Proteins) acts as scaffold protein (show HOMER1 Proteins) and activates TICAM1; N-terminal myristoylation allows TICAM2 (show TICAM2 Proteins) to anchor to endosomal membrane. (TICAM2 (show TICAM2 Proteins) = toll like receptor adaptor molecule-2 (show TICAM2 Proteins); TICAM1 = toll like receptor adaptor molecule-1; TLR4 (show TLR4 Proteins) = toll-like receptor 4 (show TLR4 Proteins)) [REVIEW]
Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (show IFNB1 Proteins) (TRIF (show TRIM69 Proteins)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (show TRIM69 Proteins)/RIPK1 (show RIPK1 Proteins)/caspase-8 (show CASP8 Proteins) occurs in fibrillary platforms.
Therefore, Seneca Valley virus suppressed antiviral interferon (show IFNA Proteins) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (show MAVS Proteins), TRIF (show TRIM69 Proteins), and TANK by its 3C protease.
TRIF (show TRIM69 Proteins) gene may contribute to susceptibility of T2DM.
The NF-kappaB (show NFKB1 Proteins) activated by dsRNA appears not to be the canonical p65 (show GORASP1 Proteins)/p50 (show CD40 Proteins) heterodimers.
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (show FOXE1 Proteins)/HEMGN, SERPINA5 (show SERPINA5 Proteins) (rs2069974), FTO (show FTO Proteins) (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (show SCARB1 Proteins) (rs11057820) genes. We found associations with SNPs in FOXE1 (show FOXE1 Proteins), SERPINA5 (show SERPINA5 Proteins), FTO (show FTO Proteins), TICAM1 and HSPA6 (show HSPA6 Proteins) and and follicular thyroid cancer
IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF (show TRIM69 Proteins).
TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT (show CHPT1 Proteins)-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line
involved in signaling that moderates the expression of heme oxygenase1 and il-8 (show IL8 Proteins) after keratinocytes exposure to dinitrochlorobenzene
Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (show DEFB103A Proteins) suppresses the polyI:C-induced TLR3 (show TLR3 Proteins) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (show IFIH1 Proteins)) and MAVS (IPS1/CARDIF (show MAVS Proteins)).
Versican (show Vcan Proteins) is produced by Trif (show RNF138 Proteins)- and type I interferon (show IFNA Proteins)-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs
TRIF (show RNF138 Proteins) contributes to murine host defense during the initial response to leptospiral infection
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA (show PCNA Proteins)- and ATM (show ATM Proteins)/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.
Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (show NCAM1 Proteins) expression are regulated by both the MyD88 (show MYD88 Proteins)- and TRIF (show RNF138 Proteins)-dependent pathways.
TRIF (show RNF138 Proteins) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Proteins) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Proteins)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)), and Tank-binding kinase 1 (TBK1 (show TBK1 Proteins)) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Proteins) and TRIF (show RNF138 Proteins).
These results suggested the importance of TRIF (show RNF138 Proteins) in TLR2 mediated foam cell formation via inflammatory mediators, including MCP-1 (show CPT1B Proteins).
DENV replication and IFNalpha/beta, TNF-alpha (show TNF Proteins), IL-12 (show IL12A Proteins) and IL-18 (show IL18 Proteins) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (show RNF138 Proteins), MYD88 (show MYD88 Proteins) or NF-kB inhibition
The authors demonstrate that, in addition to MyD88 (show MYD88 Proteins), Yersinia pseudotuberculosis inhibits TRIF (show RNF138 Proteins) signaling through the type III secretion system effector YopJ.
Results show that toll (show TLR4 Proteins)/IL-1 (show IL1A Proteins) domain-containing adaptor inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)) is essential for Toll (show TLR4 Proteins)-like receptors TLR3 (show TLR3 Proteins)- and TLR4 (show TLR4 Proteins)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
Inhibition of the Toll (show TLR4 Proteins)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (show IFNB1 Proteins) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.
3D-models of rohu TLR3 (show TLR3 Proteins)-TIR and zebrafish TRIF
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (show NFKB1 Proteins) and zebrafish type I IFN was described.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (show NFKB1 Proteins) response promoter
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
TIR domain-containing adapter molecule 1
, TIR domain containing adaptor inducing interferon-beta
, toll-interleukin I receptor domain containing adaptor molecule 1
, toll-like receptor adaptor molecule 1
, TIR domain-containing adapter molecule 1-like
, TIR domain-containing adapter protein inducing IFN-beta
, proline-rich, vinculin and TIR domain-containing protein B
, putative NF-kappa-B-activating protein 502H
, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
, TIR domain-containing adaptor inducing interferon-beta
, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
, TIR-domain containing adaptor inducing IFN-beta