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Browse our anti-TICAM2 (TICAM2) Antibodies

Full name:
anti-Toll-Like Receptor Adaptor Molecule 2 Antibodies (TICAM2)
On are 103 Toll-Like Receptor Adaptor Molecule 2 (TICAM2) Antibodies from 23 different suppliers available. Additionally we are shipping TICAM2 Proteins (12) and many more products for this protein. A total of 129 TICAM2 products are currently listed.
B430113A10, MyD88-4, TICAM-2, TIRAP3, Tirp, TRAM, Trif
list all antibodies Gene Name GeneID UniProt
TICAM2 364867  
TICAM2 353376 Q86XR7
TICAM2 225471 Q8BJQ4

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anti-Rat (Rattus) TICAM2 Antibodies:

anti-Human TICAM2 Antibodies:

anti-Mouse (Murine) TICAM2 Antibodies:

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Top referenced anti-TICAM2 Antibodies

  1. Human Monoclonal TICAM2 Primary Antibody for FACS - ABIN2665412 : Enokizono, Kumeta, Funami, Horiuchi, Sarmiento, Yamashita, Standley, Matsumoto, Seya, Inagaki: Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)
    Show all 6 references for ABIN2665412

  2. Human Polyclonal TICAM2 Primary Antibody for EIA, IF - ABIN500929 : ONeill, Fitzgerald, Bowie: The Toll-IL-1 receptor adaptor family grows to five members. in Trends in immunology 2003 (PubMed)
    Show all 4 references for ABIN500929

  3. Human Polyclonal TICAM2 Primary Antibody for DB, EIA - ABIN493396 : Oshiumi, Sasai, Shida, Fujita, Matsumoto, Seya: TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for ABIN493396

  4. Human Polyclonal TICAM2 Primary Antibody for DB, EIA - ABIN493528 : Oshiumi, Matsumoto, Funami, Akazawa, Seya: TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. in Nature immunology 2003 (PubMed)
    Show all 3 references for ABIN493528

  5. Human Polyclonal TICAM2 Primary Antibody for IHC (fro), WB - ABIN265137 : Vogel, Fitzgerald, Fenton: TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. in Molecular interventions 2004 (PubMed)
    Show all 2 references for ABIN265137

  6. Human Polyclonal TICAM2 Primary Antibody for WB - ABIN657981 : Lysakova-Devine, Keogh, Harrington, Nagpal, Halle, Golenbock, Monie, Bowie: Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Antibodies against TICAM2 Interaction Partners

Human Toll-Like Receptor Adaptor Molecule 2 (TICAM2) interaction partners

  1. Data show that Toll (show TLR4 Antibodies)/IL-1R domain-containing adaptor molecule (TICAM)-2 possesses two conserved acidic amino acids, D91 and E92, which regulate TICAM-2 self-activation and signaling.

  2. Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (show IL1B Antibodies) (P = 4.3 x 10(-5)) associated with TB.

  3. TRAM (show TRAM1 Antibodies) plays a role in TLR7 (show TLR7 Antibodies) signaling through a novel signaling axis towards the activation of anti-viral immunity.

  4. TRAM (show TRAM1 Antibodies) acts as a sorting adaptor not only for TLR4 (show TLR4 Antibodies), but also for TLR2 (show TLR2 Antibodies), to facilitate signaling to IRF7 (show IRF7 Antibodies) at the endosome, which explains how TLR2 (show TLR2 Antibodies) is capable of causing type I IFN induction.

  5. A putative TRAF6 (show TRAF6 Antibodies)-binding motif in TRAM (show TRAM1 Antibodies) may mediate a new TRAM (show TRAM1 Antibodies) function in TLR4 (show TLR4 Antibodies) signaling in regulating inflammatory responses, distinct from its bridging TLR4 (show TLR4 Antibodies) and TRIF (show TRIM69 Antibodies). A TRAM (show TRAM1 Antibodies) E183A mutation abolished this.

  6. results suggest TLR adaptor molecules knockdown, such as MyD88 (show MYD88 Antibodies) or TRAM (show TRAM1 Antibodies), can decrease IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) mRNA and increase CXCL12 (show CXCL12 Antibodies) mRNA expression in HGF (show HGF Antibodies) and HPDLF.

  7. The homotypic interaction between TICAM-2 TIR is indispensable to present a scaffold for recruiting the monomeric moiety of the TICAM-1 (show TICAM1 Antibodies) TIR dimer.

  8. induction of both IL-6 (show IL6 Antibodies) and IL-8 (show IL8 Antibodies) is associated with elevated TIRAP (show TIRAP Antibodies) and reduced TRAM (show TRAM1 Antibodies) mRNA expression

  9. Data indicate that MyD88 (show MYD88 Antibodies) works together with the IL-1 (show IL1A Antibodies)/IL-18 (show IL18 Antibodies) receptors, can interact with two distinct sorting adaptors, TRAM (show TRAM1 Antibodies) and Mal (show MAL Antibodies), in a conserved manner.

  10. viral inhibitor peptide of TLR4 (show TLR4 Antibodies) possibly represents a surface domain of A46 that specifically inhibits TLR4 (show TLR4 Antibodies) by masking critical binding sites on MyD88 adaptor (show MYD88 Antibodies)-like and TRIF-related adaptor molecule

Mouse (Murine) Toll-Like Receptor Adaptor Molecule 2 (TICAM2) interaction partners

  1. TRIF (show RNF138 Antibodies)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 (show TLR4 Antibodies) and 3. JNK (show MAPK8 Antibodies)-dependent mechanisms likely mediate this downregulation.

  2. Data show that annexin A2 (AnxA2 (show ANXA2 Antibodies)) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4 (show TLR4 Antibodies))-initiated TRAM protein (show TRAM2 Antibodies)-TRIF (show RNF138 Antibodies) protein pathway occurring on endosomes.

  3. TRIF (show RNF138 Antibodies) mediates antibacterial defense during Gram-negative pneumonia, at least in part, by inducing IFN-x03B3; at the primary site of infection.

  4. The authors confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3 (show TLR3 Antibodies)-mediated TRIF (show RNF138 Antibodies) signaling by using TLR3 (show TLR3 Antibodies)-deficient mice.

  5. MMP-12 (show MMP12 Antibodies) up-regulation mediated by SARM (show SARM1 Antibodies)-TRIF (show RNF138 Antibodies) signaling pathway contributes to IFN-gamma (show IFNG Antibodies)-independent airway inflammation and AHR (show AHR Antibodies) post RSV infection in nude mice.

  6. HMGB1 (show HMGB1 Antibodies) and its downstream TLR4 (show TLR4 Antibodies)/Myd88 (show MYD88 Antibodies)/TRIF (show RNF138 Antibodies) signaling pathway play important roles in the mouse intestinal I/R injury.

  7. TLR4 (show TLR4 Antibodies), TRIF (show RNF138 Antibodies), and MyD88 (show MYD88 Antibodies) mediate the intraocular inflammatory response in endophthalmitis caused by Bacillus cereus.

  8. TRIF (show RNF138 Antibodies) is a mediator of the innate and adaptive immune interactions in the protective properties of memory immunity against Gram-negative bacteria.

  9. Inhibitory effects of SP were mediated through the regulation of TRIF (show RNF138 Antibodies)-dependent signaling.

  10. These findings indicate that a balanced immune response operating through both TRIF (show RNF138 Antibodies)-driven and MyD88 (show MYD88 Antibodies)-driven pathways likely provides the most effective host cell intrinsic antiviral defense responses to severe SARS (show SARS Antibodies)-CoV disease

TICAM2 Antigen Profile

Antigen Summary

TIRP is a Toll/interleukin-1 receptor (IL1R\; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4\; MIM 603030).

Alternative names and synonyms associated with TICAM2

  • toll-like receptor adaptor molecule 2 (Ticam2) antibody
  • toll-like receptor adaptor molecule 2 (TICAM2) antibody
  • B430113A10 antibody
  • MyD88-4 antibody
  • TICAM-2 antibody
  • TIRAP3 antibody
  • Tirp antibody
  • TRAM antibody
  • Trif antibody

Protein level used designations for TICAM2

TIR domain-containing adapter molecule 2 , TMED7-TICAM2 readthrough , NF-kappa-B-activating protein 502 , TRIF-related adaptor molecule , cytoplasmic adaptor , putative NF-kappa-B-activating protein 502 , toll-like receptor adaptor protein 3 , toll/interleukin-1 receptor (TIR) domain-containing adapter protein , TIR domain-containing adapter protein , TRIF-related adapter molecule TRAM , Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2 , toll/interleukin-1 receptor domain-containing protein , TRIF-related adapter molecule

364867 Rattus norvegicus
100029323 Monodelphis domestica
100409449 Callithrix jacchus
100500706 Pan troglodytes
100520421 Sus scrofa
100529854 Equus caballus
100533188 Canis lupus familiaris
353376 Homo sapiens
225471 Mus musculus
539350 Bos taurus
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