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Human Polyclonal TLR10 Primary Antibody for EIA, WB - ABIN493512
Nyman, Stenmark, Flodin, Johansson, Hammarström, Nordlund: The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. in The Journal of biological chemistry 2008
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Human Monoclonal TLR10 Primary Antibody for ICFC - ABIN2662577
Bourke, Bosisio, Golay, Polentarutti, Mantovani: The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. in Blood 2003
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Human Monoclonal TLR10 Primary Antibody for IF - ABIN2665653
Chuang, Ulevitch: Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. in Biochimica et biophysica acta 2001
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Human Polyclonal TLR10 Primary Antibody for EIA, WB - ABIN500940
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
Show all 2 references for ABIN500940
phylogenetic analysis of the cytoplasmic regions of TLR genes suggested that the signal transduction pathway of TLR10 was different from those of TLR1 (show TLR1 Antibodies) and TLR6 (show TLR6 Antibodies)
Study annotated variants at 4p14 as expression quantitative trait loci (eQTL) associated with TLR6/10 and FAM114A1; findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.
concluded that TLR-1 (show TLR1 Antibodies) rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease
genetic variants in TLR10 are associated with protection against complicated skin and skin structure infections
TLR1 (show TLR1 Antibodies) rs4833095 and TLR10 rs10004195 may play crucial roles in H. pylori susceptibility and gastric pathogenesis.
Our results suggest that TLR10 polymorphisms may contribute to the pathogenesis of autoimmune thyroid diseases.
single nucleotide polymorphism (SNP) in TLR10 (rs11096957) is associated with risk for Tuberculosis
Genetic variation rs5743565 in TLR1 (show TLR1 Antibodies) might be associated with the decreased susceptibility to Graves disease, whlie polymorphisms in TLR6 (show TLR6 Antibodies) and TLR10 did not reach the statistical significance.
The correlation between TLR1 (show TLR1 Antibodies), TLR6 (show TLR6 Antibodies), and TLR10 polymorphisms and the development of atopic dermatitis in the Republic of Bashkortostan has been found.
The results suggest roles for TLR3 (show TLR3 Antibodies), TLR10, PLAT (show PLAT Antibodies) (n=2), VEGFA (show VEGFA Antibodies) and DENND1B (show DENND1B Antibodies) in susceptibility to chronic cavitary pulmonary aspergillosis.
TLR10 is a modulatory pattern-recognition receptor with mainly inhibitory properties
The expression analysis showed similar expression profiles for TLR1 (show TLR1 Antibodies) and TLR6 (show TLR6 Antibodies), which indicate a co-regulation of these two genes, TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 (show TLR1 Antibodies) and TLR6 (show TLR6 Antibodies).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
toll-like receptor 10
, toll-like receptor 10-like