Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
TLR2 priming (via Pam3Csk4) would inhibit TLR4 (show TLR4 Antibodies)-mediated responses while TLR3 (show TLR3 Antibodies) priming (via Poly I:C) would enhance subsequent TLR4 (show TLR4 Antibodies)-inflammatory signaling.
There were no differences between T2D and HC, except for a larger decrease in plasma TNF-alpha (show TNF Antibodies) in HC vs. T2D (group x time interaction, P < 0.05). One session of low-volume HIIT has immunomodulatory effects and provides potential anti-inflammatory benefits to people with, and without, T2D.
we have demonstrated that B. burgdorferi-induced DC migration is mediated by TLR2. Our findings underscore the utility of this model as a valuable tool to study immunity to spirochetal infections.
TLR2 has protumorigenic and prometastatic effects in intrahepatic cholangiocarcinoma through the upregulation of inflammatory cytokines induced by the activation of NF-kappaB (show NFKB1 Antibodies) signaling
Cytokine production induced by invasive S. mutans via intracellular TLR2 and NOD2 (show NOD2 Antibodies) in HAECs may be associated with inflammation.
Normothermic Ex Vivo Lung Perfusion in Brain-dead Donors Reduces Inflammatory Cytokines and Toll (show TLR4 Antibodies)-like Receptor Expression.
Studied the relationship between polymorphisms in MBL (show MBL2 Antibodies), TLR1 (show TLR1 Antibodies), TLR2 and TLR6 (show TLR6 Antibodies) encoding genes and stimulated IFN-gamma (show IFNG Antibodies) and IL-12 (show IL12A Antibodies) ex vivo production in BCG (show SLC11A1 Antibodies) osteitis survivors. Found that variant genotypes of the MBL2 (show MBL2 Antibodies) gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma (show IFNG Antibodies) production.
Meta-analysis revealed that the TLR2 rs4696480 polymorphism is significantly associated with asthma susceptibility, and the TLR2 rs4696480 polymorphism is a risk factor for asthma.
the colonic tissue levels of TLR2 and TLR4 (show TLR4 Antibodies) and nitric oxide were elevated in Irritable bowel syndrome patients; results support the presence of a degree of immune dysregulation and oxidative stress in patients with Irritable bowel syndrome
Results suggest a potential role for the host genetic background in diabetes mellitus type 2 diabetic foot susceptibility and demonstrate that there is an association between TLR9 (show TLR9 Antibodies)-1237 T/C polymorphism and the risk of diabetic foot, but no association was found with TLR2
TLR2 signaling promotes the development of Malignant Pleural Effusion.
Murine intravital thrombosis studies demonstrated that CAP-PEs (show PES1 Antibodies) accelerate thrombosis in TLR2-dependent manner and that TLR2 contributes to accelerate thrombosis in mice in the settings of hyperlipidemia.
These findings demonstrate that PGN (show SPG7 Antibodies) promotes the secretion of G-CSF (show CSF3 Antibodies) from monocytes and endothelial cells, leading to the acceleration of granulopoiesis. Our results illustrate that bacterial recognition by TLR2 facilitates granulopoiesis during Gram-positive bacterial infection.
Cathepsin S (show CTSS Antibodies) activity controls injury-related vascular remodeling via TLR2/p38MAPK (show MAPK14 Antibodies)/PI3K/Akt (show AKT1 Antibodies)/p-HDAC6 (show HDAC6 Antibodies) signaling pathway.
The adapter Mal (show TIRAP Antibodies) (encoded by TIRAP (show TIRAP Antibodies)) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal (show TIRAP Antibodies) was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9 (show TLR9 Antibodies).
data indicate that increased levels of TLR2 and TLR4 (show TLR4 Antibodies) in the liver and spleen may play an important role during acute T. gondii infection
the role of Toll (show TLR4 Antibodies)-like receptor (TLR) 2, TLR4 (show TLR4 Antibodies), myeloid differentiation response gene 88, and Toll (show TLR4 Antibodies)-IL-1 (show IL1A Antibodies) receptor domain-containing adaptor-inducing interferon-gamma (show IFNG Antibodies) (TRIF (show RNF138 Antibodies)), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis.
This study showed that although TLR2 is an important mediator of the early inflammatory response, it is dispensable for protective immunity against O. tsutsugamushi
this study shows an inflammatory role for TLR2 in mouse hepatitis virus-induced acute fulminant hepatitis
these data identify Trim13 (show TRIM13 Antibodies) as a positive regulator of NF-kappaB (show NFKB1 Antibodies) activation and suggest that lysine 29-linked polyubiquitination is a specific ubiquitin-linked pattern involved in the control of TLR2 signaling.
Transcription levels of TLR2, TLR4 (show TLR4 Antibodies), and CD14 (show CD14 Antibodies) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 Antibodies) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 Antibodies) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 Antibodies), and TLR6 (show TLR6 Antibodies) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 Antibodies); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 Antibodies) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 Antibodies) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
ALOX5AP (show ALOX5AP Antibodies), CPNE3 (show CPNE3 Antibodies), IL1R2 (show IL1R2 Antibodies), IL6 (show IL6 Antibodies), TLR2, TLR4 (show TLR4 Antibodies), and THY1 (show THY1 Antibodies) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 Antibodies) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 Antibodies) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Antibodies) secretion via the TLR2/MyD88 (show MYD88 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 Antibodies) and TLR9 (show TLR9 Antibodies) contribute to NF-kappaB (show NFKB1 Antibodies) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Antibodies).
Data suggest TLR2, TLR4 (show TLR4 Antibodies), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 Antibodies).
TLR2 is required for the suppression of TLR4 (show TLR4 Antibodies) signaling activation.
The role of TLR2, TLR4 (show TLR4 Antibodies) and RP105 (show CD180 Antibodies)/MD1 (show LY86 Antibodies) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Antibodies), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 Antibodies) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 Antibodies), TLR2, and TLR6 (show TLR6 Antibodies), respectively; in TLR1 (show TLR1 Antibodies) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
expression of TLR4 (show TLR4 Antibodies) and TLR2 in normal and LPS (show IRF6 Antibodies)-treated horses
Because factors other than mastitis can affect SCC (show CYP11A1 Antibodies) and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC (show CYP11A1 Antibodies) or mastitis in goats.
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ Antibodies) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 Antibodies). burgdorferi through TLR1 (show TLR1 Antibodies)/2 and TLR5 (show TLR5 Antibodies).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein