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Mouse (Murine) Monoclonal TLR2 Primary Antibody for Func, IA - ABIN2191804
Meng, Rutz, Schiemann, Metzger, Grabiec, Schwandner, Luppa, Ebel, Busch, Bauer, Wagner, Kirschning: Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. in The Journal of clinical investigation 2004
Show all 6 references for ABIN2191804
Mouse (Murine) Monoclonal TLR2 Primary Antibody for Func, IA - ABIN2191805
Roura-Mir, Wang, Cheng, Matsunaga, Dascher, Peng, Fenton, Kirschning, Moody: Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 5 references for ABIN2191805
these results suggest that targeting the COX-2 (show COX2 Antibodies)/PGE2 pathway together with TLR/MyD88 (show MYD88 Antibodies) signaling, which would suppress the inflammatory microenvironment and maintenance of stemness, could be an effective preventive or therapeutic strategy for gastric cancer
expression and activity of TLR2 and 4 in peripheral blood monocytes as well as B cells in in type-2 diabetic subjects; surface expression of TLR2 and 4 was significantly reduced in B cells of the newly diagnosed type-2 diabetic subjects and was associated with decreased cellular activation and cytokine secretion
OSA patients had increased TLR2/6 co-expressions on blood immune cells, which were related to their immune cell counts and could be reversed with CPAP (show CENPJ Antibodies) treatment. In vitro IHR could induce TLR2/6 co-upregulation.
PRG4 (show PRG4 Antibodies) binds to TLR2 and TLR4 (show TLR4 Antibodies) and this binding mediates a novel anti-inflammatory role for PRG4 (show PRG4 Antibodies)
study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (show CLEC7A Antibodies) (rs7309123) or TLR2 (rs5743708) represents an independent risk factor of developing IFD in patients with AML (show RUNX1 Antibodies) undergoing induction chemotherapy.
TLR2 participates in the signaling of Burkholderia pseudomallei lipopolysaccharide.
The role of TLR-2 in systemic lupus erythematosus and periodontal disease (review)
a direct effect of the TLR2 Arg753Gln polymorphism on sepsis risk, especially in Europeans(Meta-Analysis)
Data suggest that activation of TLR2 (here, using TLR2 ligand peptidoglycan) directly increases NGF gene expression and protein levels in cells isolated from intervertebral discs (nucleus pulposus or annulus fibrosus) obtained from tissue donors.
Whole-body vibration improves the anti-inflammatory status in elderly subjects through toll-like receptor 2 and 4 signaling pathways.
HMGB1 (show HMGB1 Antibodies)-TLR2/TLR4 (show TLR4 Antibodies) signaling cascade.
The mRNA and protein expression of TLR2 and its downstream mediators in the brain tissue were also significantly lowered in mice treated with Corilagin.
These results expand on our knowledge of the roles for TLR2 and TLR4 (show TLR4 Antibodies) in C. burnetii infection and suggest various roles for these receptors that are dictated by the site of infection.
In conclusion, our data indicate that, similar to TLR4 (show TLR4 Antibodies), TLR2 plays a critical role in radio-resistance.
Control of Methicillin-Resistant Staphylococcus aureus Pneumonia Utilizing TLR2 Agonist Pam3CSK4.
This study provides insights into the essential role of TLR2 dimerization in the activation of pathogenic pro-inflammatory Ly6C(hi) monocytes during DSS (show PMP22 Antibodies)-induced colitis.
demonstrated that the PGRS domain is required to mediate cell entry into macrophages, with the key domain encompassing position 140-260 amino acids of PE_PGRS33. PE_PGRS33-mediated entry into macrophages was abolished in TLR2-deficient mice
This study demonstrated that the Toll like receptor-2 regulates production of glial-derived neurotrophic factors in murine intestinal smooth muscle cells
TLR2 ligand Ara (show FOXC1 Antibodies)-LAM (show LSAMP Antibodies)-induced TLR2 signaling leads to the activation of the transcription factor T-bet which plays a pivotal role in restoring the effector functions of CD8 (show CD8A Antibodies)+ T-cells in L. donovani infected susceptible host
Data indicated that inoculation with peptidoglycan-polysaccharide effectively induced otitis media (OM) in TLR2-/- mice, which provided a novel model for exploring the molecular pathogenesis of OM.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 Antibodies) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 Antibodies) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 Antibodies), and TLR6 (show TLR6 Antibodies) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 Antibodies); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 Antibodies) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 Antibodies) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
ALOX5AP (show ALOX5AP Antibodies), CPNE3 (show CPNE3 Antibodies), IL1R2 (show IL1R2 Antibodies), IL6 (show IL6 Antibodies), TLR2, TLR4 (show TLR4 Antibodies), and THY1 (show THY1 Antibodies) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This study showed that TLR1 (show TLR1 Antibodies) and TLR2 together are necessary for the recognition of triacylated lipopeptides.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 Antibodies) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 Antibodies) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Antibodies) secretion via the TLR2/MyD88 (show MYD88 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 Antibodies) and TLR9 (show TLR9 Antibodies) contribute to NF-kappaB (show NFKB1 Antibodies) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Antibodies).
Data suggest TLR2, TLR4 (show TLR4 Antibodies), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 Antibodies).
TLR2 is required for the suppression of TLR4 (show TLR4 Antibodies) signaling activation.
The role of TLR2, TLR4 (show TLR4 Antibodies) and RP105 (show CD180 Antibodies)/MD1 (show LY86 Antibodies) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Antibodies), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 Antibodies) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 Antibodies), TLR2, and TLR6 (show TLR6 Antibodies), respectively; in TLR1 (show TLR1 Antibodies) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
both TLR2 and TLR6 (show TLR6 Antibodies) are important in the recognition of M. hyopneumoniae in porcine alveolar macrophages
expression of TLR4 (show TLR4 Antibodies) and TLR2 in normal and LPS (show IRF6 Antibodies)-treated horses
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ Antibodies) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 Antibodies). burgdorferi through TLR1 (show TLR1 Antibodies)/2 and TLR5 (show TLR5 Antibodies).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein