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Only the TLR2 +596 SNP was found to be significantly associated to asthma (OR = 3.24 for CT, 2.71 for TT) and particularly to females. The identification of TLR SNPs will reveal potential candidates for gene-environment interactions in Puerto Ricans.
relative frequency of TLR2 polymorphism was similar in heart transplant (HTX (show ZIC3 Antibodies)) patients and blood donors; TLR2 polymorphism was neither associated with occurrence or level of cytomegalovirus (CMV) infection nor with survival, graft failure or rejection, or CMV serostatus of patient before transplantation
this study shows that neutrophil expression levels of TLR2 are increased in septic patients
in this study using TLR2 and TLR4 (show TLR4 Antibodies)-reporter cells, lipoproteins were found to inhibit TLR responses with differences in affinity and kinetics
High TLR2 expression is associated with gastric cancer.
Data suggest that anti-inflammatory effects of DHA (and inflammatory effects of palmitic acid) are at least in part mediated through modulating ER homeostasis; ER stress can be differentially modulated by various types of dietary fat; DHA down-regulates ligand-induced activation of TLR2 and TLR4 (show TLR4 Antibodies) in activated monocytes. (DHA = docosahexaenoic acid; ER = endoplasmic reticulum; TLR = toll (show TLR4 Antibodies)-like receptor)
these results reveal a novel role of T-cell expressed TLR2 in enhancing the differentiation and function of TH9 T cells
TLR2 plays a key role in platelet hyperreactivity and the prothrombotic state in the setting of hyperlipidemia by sensing a wide range of endogenous lipid peroxidation ligands and activating innate immune signaling cascade in platelets.
These data illustrate a functional role for TLR2 in the pathogenesis of choroidal neovascularization.
The combined results of this meta-analysis show that rs3804099 in TLR2 and rs4986791 in TLR4 (show TLR4 Antibodies) were significantly associated with asthma risk
strains that preferentially activate TLR2, and others that also activate TLR4 (show TLR4 Antibodies)
a role for TLR2 in controlling cutaneous leishmaniasis disease severity has been demonstrated in vivo; absence of this phenotype in either TLR1 (show TLR1 Antibodies)-/- or TLR6 (show TLR6 Antibodies)-/- mice suggests that TLR2 does not have a specific requirement for either known co-receptor during Leishmania infection; findings indicate that parasite lipophosphoglycan is not required for the observed TLR2 mediated effects
The present results indicate that the lack of TLR2 does affect the nerve regeneration process in sciatic nerve disease.
results suggest that B. tropicalis allergens engage TLR4 (show TLR4 Antibodies) that potentiates TLR2 signaling.
This study reveals the striking ability of a prototypical innate immune receptor to trigger a potent and suppressive IL-10 (show IL10 Antibodies) response in effector/memory T cells, supporting the notion that TLR2 is a co-regulatory receptor on T cells.
Dual TLR2/TLR7 (show TLR7 Antibodies) agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8 (show CD8A Antibodies)(+) T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced TH1 (show HAND1 Antibodies)/TH2 profile in mice.
In conclusion, the authors demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response.
results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle
Transcription levels of TLR2, TLR4 (show TLR4 Antibodies), and CD14 (show CD14 Antibodies) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 Antibodies) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 Antibodies) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 Antibodies), and TLR6 (show TLR6 Antibodies) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 Antibodies); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 Antibodies) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 Antibodies) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 Antibodies) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 Antibodies) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Antibodies) secretion via the TLR2/MyD88 (show MYD88 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 Antibodies) and TLR9 (show TLR9 Antibodies) contribute to NF-kappaB (show NFKB1 Antibodies) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Antibodies).
Data suggest TLR2, TLR4 (show TLR4 Antibodies), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 Antibodies).
TLR2 is required for the suppression of TLR4 (show TLR4 Antibodies) signaling activation.
The role of TLR2, TLR4 (show TLR4 Antibodies) and RP105 (show CD180 Antibodies)/MD1 (show LY86 Antibodies) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Antibodies), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 Antibodies) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 Antibodies), TLR2, and TLR6 (show TLR6 Antibodies), respectively; in TLR1 (show TLR1 Antibodies) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
expression of TLR4 (show TLR4 Antibodies) and TLR2 in normal and LPS (show IRF6 Antibodies)-treated horses
Because factors other than mastitis can affect SCC (show CYP11A1 Antibodies) and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC (show CYP11A1 Antibodies) or mastitis in goats.
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ Antibodies) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 Antibodies). burgdorferi through TLR1 (show TLR1 Antibodies)/2 and TLR5 (show TLR5 Antibodies).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein