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HBsAg simulation increased proinflammatory cytokine production and invasion of HepG2.2.15 cells, while this process was inhibited by TLR2 silence.
this review highlights the contribution of TLR2 to host protection, immune evasion by Mycobacterium tuberculosis and immune regulation during chronic Mycobacterium tuberculosis infection
treatment with an antibody against Toll (show TLR4 Antibodies)-like receptor (TLR) 2 reversed the effect of L. paracasei on inducing negative regulators and inhibiting TNF-alpha (show TNF Antibodies) and IL-1beta (show IL1B Antibodies) productions.
Neonatal cells were more potent in the activation of ERK (show EPHB2 Antibodies) and Akt (show AKT1 Antibodies) through TLR2 and TLR4 (show TLR4 Antibodies) co-activation.
T. denticola stimulates the innate immune system in a TLR2-dependent fashion.
This study shows TLR2 signalling induce cytokine production and regulate wnt (show WNT2 Antibodies) signalling thereby cause maturation of megakaryocyte.
Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins.
elevated expression of TLR2 on CD14 (show NDUFA2 Antibodies)+ monocytes in pulmonary tuberculosis patients confirms the role of TLR2 in host defense against M. tuberculosis. 597T/C polymorphism of TLR 2 gene may be a risk factor for susceptibility to pulmonary tuberculosis in a sample Egyptian population.
Lentiviral gene transfer or knockdown of PPP1R11 (show PPP1R11 Antibodies) in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 (show PPP1R11 Antibodies) and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections
study to examine potential associations between a selection of SNPs in the genes encoding TLR2 and TOLLIP (show TOLLIP Antibodies), and predisposition, severity and outcome of Staphylococcus aureus bloodstream infections (SABSI); the TLR2 and TOLLIP (show TOLLIP Antibodies) polymorphisms were not associated with susceptibility to SABSI, severity, 30-day all-cause mortality, or SABSI caused by the clonal complex 30 genotype
results suggest that the TLR2-p38 (show CRK Antibodies)-CD86 (show CD86 Antibodies) signaling pathway plays a vital role in inflammation associated with burn injury
TLR2 and TLR4 (show TLR4 Antibodies) modulate the serotonin contractile motor response in mouse colon.
Isoflurane relieves zymosan-induced neutrophil inflammatory lung response by targeting NMDA glutamate receptor (show GRIN1 Antibodies) and Toll-like receptor 2 signaling pathway.
Results of RNA-sequencing demonstrated roles for TLR2 varied by cell type during T. gondii infection. Our findings facilitate understanding of the detailed relationship between TLR2 and T. gondii infection, and elucidate mechanisms underlying neurological changes during infection
TLR2 expression on B1a cells is not critical for their IgM-dependent atheroprotection.
Artificially applied c-kit (show KIT Antibodies)(+) cells interact with the target organ endothelium following ischemia reperfusion injury. This interaction seems to depend on TLR-MyD88 (show MYD88 Antibodies) signaling.
our results demonstrate that 5-HT (show DDC Antibodies) induces the invasion of commensal E. coli into gut (show GUSB Antibodies) submucosa by amplifying commensal bacteria-induced epithelial signaling (superoxide production and the inductions of NOX2 (show CYBB Antibodies) and TLR2/TLR4 (show TLR4 Antibodies)). The authors suggest that these changes may constitute the molecular basis for the pathogenesis of inflammatory bowel disease (IBD).
TLR2 signaling could be involved in the increase in the B-1 cell population induced by Propionibacterium acnes.
These studies reveal that the costimulatory effects of TLR1 (show TLR1 Antibodies)-TLR2 signaling in CD8 (show CD8A Antibodies)(+) T cells are in part mediated by 4-1BB (show TNFRSF9 Antibodies) and are important for mounting an effective antitumor immune response.
results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle
Transcription levels of TLR2, TLR4 (show TLR4 Antibodies), and CD14 (show CD14 Antibodies) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 Antibodies) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 Antibodies) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 Antibodies), and TLR6 (show TLR6 Antibodies) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 Antibodies); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 Antibodies) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 Antibodies) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 Antibodies) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 Antibodies) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
we assume that reduced TLR2 expression may be responsible for the decreased phagocytizing capacity of circulating monocytes in the early post-traumatic phase
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 Antibodies) secretion via the TLR2/MyD88 (show MYD88 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 Antibodies) and TLR9 (show TLR9 Antibodies) contribute to NF-kappaB (show NFKB1 Antibodies) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Antibodies).
Data suggest TLR2, TLR4 (show TLR4 Antibodies), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 Antibodies).
TLR2 is required for the suppression of TLR4 (show TLR4 Antibodies) signaling activation.
The role of TLR2, TLR4 (show TLR4 Antibodies) and RP105 (show CD180 Antibodies)/MD1 (show LY86 Antibodies) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Antibodies), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 Antibodies) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
expression of TLR4 (show TLR4 Antibodies) and TLR2 in normal and LPS (show IRF6 Antibodies)-treated horses
Because factors other than mastitis can affect SCC (show CYP11A1 Antibodies) and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC (show CYP11A1 Antibodies) or mastitis in goats.
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ Antibodies) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 Antibodies). burgdorferi through TLR1 (show TLR1 Antibodies)/2 and TLR5 (show TLR5 Antibodies).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein