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the colonic tissue levels of TLR2 and TLR4 (show TLR4 ELISA Kits) and nitric oxide were elevated in Irritable bowel syndrome patients; results support the presence of a degree of immune dysregulation and oxidative stress in patients with Irritable bowel syndrome
Results suggest a potential role for the host genetic background in diabetes mellitus type 2 diabetic foot susceptibility and demonstrate that there is an association between TLR9 (show TLR9 ELISA Kits)-1237 T/C polymorphism and the risk of diabetic foot, but no association was found with TLR2
Dimeric BCAP (show PHF11 ELISA Kits) associates with the TIR domains of TLR2/4 and MAL/TIRAP (show TIRAP ELISA Kits), suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions.
Finally, Fusobacterium nucleatum FAD (show BRCA2 ELISA Kits)-I activation of human BD-2 (show DEFB4 ELISA Kits) expression was mediated via both Toll-like receptor-1 (show TLR1 ELISA Kits)/2 (TLR-1 (show TLR1 ELISA Kits)/2) and TLR-2/6 heterodimerization.
We demonstrate that TLR2 ligation in CD3 (show CD3 ELISA Kits)/CD28 (show CD28 ELISA Kits)-costimulated CCR6 (show CCR6 ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) T cells leads to enhanced virus production. Our results highlight the potential impact of bacterial translocation on the overall permissiveness of CCR6 (show CCR6 ELISA Kits)(+) CD4 (show CD4 ELISA Kits)(+) T cells to productive HIV-1 infection.
One single nucleotide polymorphisms in toll like receptor 2 was significantly associated with bleeding on probing.
The SNP rs3804099 of TLR2 may have significant effects on heritability of psoriasis vulgaris in Chinese population.
Based on these results, it is possible that expression of porin (show VDAC1 ELISA Kits) sequence variants that strongly induce TLR2 activation may be a mechanism to enhance the invasive features of pathogenic Neisseriae strains.
TLR2 polymorphisms were associated with recurrent acute otitis media.
this study shows that an increase in CD14 (show NDUFA2 ELISA Kits)+ TLR-2+ monocytes within the 90 days post-transplantation was associated with increased risk of kidney allograft dysfunction at 180 and 365 days post-transplantation
The adapter Mal (show TIRAP ELISA Kits) (encoded by TIRAP (show TIRAP ELISA Kits)) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal (show TIRAP ELISA Kits) was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9 (show TLR9 ELISA Kits).
data indicate that increased levels of TLR2 and TLR4 (show TLR4 ELISA Kits) in the liver and spleen may play an important role during acute T. gondii infection
the role of Toll (show TLR4 ELISA Kits)-like receptor (TLR) 2, TLR4 (show TLR4 ELISA Kits), myeloid differentiation response gene 88, and Toll (show TLR4 ELISA Kits)-IL-1 (show IL1A ELISA Kits) receptor domain-containing adaptor-inducing interferon-gamma (show IFNG ELISA Kits) (TRIF (show RNF138 ELISA Kits)), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis.
This study showed that although TLR2 is an important mediator of the early inflammatory response, it is dispensable for protective immunity against O. tsutsugamushi
this study shows an inflammatory role for TLR2 in mouse hepatitis virus-induced acute fulminant hepatitis
these data identify Trim13 (show TRIM13 ELISA Kits) as a positive regulator of NF-kappaB (show NFKB1 ELISA Kits) activation and suggest that lysine 29-linked polyubiquitination is a specific ubiquitin-linked pattern involved in the control of TLR2 signaling.
The authors provide evidence that TLR2 activation of liver sinusoidal endothelial cells by mouse hepatitis virus type 3 is an aggravating factor of hepatic inflammation and correlates with the severity of hepatitis.
These results point out to a role of TLR2 in gut (show GUSB ELISA Kits) protection against colonization and endogenous invasion by Candida albicans.
Paeoniflorin inhibits high glucose-induced macrophage activation through TLR2-dependent signal pathways.
Data, including data from studies using knockout mice, suggest that signaling via Tlr2 is involved in inflammatory response induced by Bothrops atrox snake venom.
Transcription levels of TLR2, TLR4 (show TLR4 ELISA Kits), and CD14 (show CD14 ELISA Kits) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 ELISA Kits) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 ELISA Kits) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 ELISA Kits), and TLR6 (show TLR6 ELISA Kits) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 ELISA Kits); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 ELISA Kits) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 ELISA Kits) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
ALOX5AP (show ALOX5AP ELISA Kits), CPNE3 (show CPNE3 ELISA Kits), IL1R2 (show IL1R2 ELISA Kits), IL6 (show IL6 ELISA Kits), TLR2, TLR4 (show TLR4 ELISA Kits), and THY1 (show THY1 ELISA Kits) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 ELISA Kits) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 ELISA Kits) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 ELISA Kits) secretion via the TLR2/MyD88 (show MYD88 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 ELISA Kits) and TLR9 (show TLR9 ELISA Kits) contribute to NF-kappaB (show NFKB1 ELISA Kits) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 ELISA Kits).
Data suggest TLR2, TLR4 (show TLR4 ELISA Kits), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 ELISA Kits).
TLR2 is required for the suppression of TLR4 (show TLR4 ELISA Kits) signaling activation.
The role of TLR2, TLR4 (show TLR4 ELISA Kits) and RP105 (show CD180 ELISA Kits)/MD1 (show LY86 ELISA Kits) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 ELISA Kits), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 ELISA Kits) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 ELISA Kits), TLR2, and TLR6 (show TLR6 ELISA Kits), respectively; in TLR1 (show TLR1 ELISA Kits) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
expression of TLR4 (show TLR4 ELISA Kits) and TLR2 in normal and LPS (show IRF6 ELISA Kits)-treated horses
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ ELISA Kits) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 ELISA Kits). burgdorferi through TLR1 (show TLR1 ELISA Kits)/2 and TLR5 (show TLR5 ELISA Kits).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein