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TLR2 priming (via Pam3Csk4) would inhibit TLR4 (show TLR4 ELISA Kits)-mediated responses while TLR3 (show TLR3 ELISA Kits) priming (via Poly I:C) would enhance subsequent TLR4 (show TLR4 ELISA Kits)-inflammatory signaling.
There were no differences between T2D and HC, except for a larger decrease in plasma TNF-alpha (show TNF ELISA Kits) in HC vs. T2D (group x time interaction, P < 0.05). One session of low-volume HIIT has immunomodulatory effects and provides potential anti-inflammatory benefits to people with, and without, T2D.
we have demonstrated that B. burgdorferi-induced DC migration is mediated by TLR2. Our findings underscore the utility of this model as a valuable tool to study immunity to spirochetal infections.
TLR2 has protumorigenic and prometastatic effects in intrahepatic cholangiocarcinoma through the upregulation of inflammatory cytokines induced by the activation of NF-kappaB (show NFKB1 ELISA Kits) signaling
Cytokine production induced by invasive S. mutans via intracellular TLR2 and NOD2 (show NOD2 ELISA Kits) in HAECs may be associated with inflammation.
Normothermic Ex Vivo Lung Perfusion in Brain-dead Donors Reduces Inflammatory Cytokines and Toll (show TLR4 ELISA Kits)-like Receptor Expression.
Studied the relationship between polymorphisms in MBL (show MBL2 ELISA Kits), TLR1 (show TLR1 ELISA Kits), TLR2 and TLR6 (show TLR6 ELISA Kits) encoding genes and stimulated IFN-gamma (show IFNG ELISA Kits) and IL-12 (show IL12A ELISA Kits) ex vivo production in BCG (show SLC11A1 ELISA Kits) osteitis survivors. Found that variant genotypes of the MBL2 (show MBL2 ELISA Kits) gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma (show IFNG ELISA Kits) production.
Meta-analysis revealed that the TLR2 rs4696480 polymorphism is significantly associated with asthma susceptibility, and the TLR2 rs4696480 polymorphism is a risk factor for asthma.
the colonic tissue levels of TLR2 and TLR4 (show TLR4 ELISA Kits) and nitric oxide were elevated in Irritable bowel syndrome patients; results support the presence of a degree of immune dysregulation and oxidative stress in patients with Irritable bowel syndrome
Results suggest a potential role for the host genetic background in diabetes mellitus type 2 diabetic foot susceptibility and demonstrate that there is an association between TLR9 (show TLR9 ELISA Kits)-1237 T/C polymorphism and the risk of diabetic foot, but no association was found with TLR2
TLR2 signaling promotes the development of Malignant Pleural Effusion.
Murine intravital thrombosis studies demonstrated that CAP-PEs (show PES1 ELISA Kits) accelerate thrombosis in TLR2-dependent manner and that TLR2 contributes to accelerate thrombosis in mice in the settings of hyperlipidemia.
These findings demonstrate that PGN (show SPG7 ELISA Kits) promotes the secretion of G-CSF (show CSF3 ELISA Kits) from monocytes and endothelial cells, leading to the acceleration of granulopoiesis. Our results illustrate that bacterial recognition by TLR2 facilitates granulopoiesis during Gram-positive bacterial infection.
Cathepsin S (show CTSS ELISA Kits) activity controls injury-related vascular remodeling via TLR2/p38MAPK (show MAPK14 ELISA Kits)/PI3K/Akt (show AKT1 ELISA Kits)/p-HDAC6 (show HDAC6 ELISA Kits) signaling pathway.
The adapter Mal (show TIRAP ELISA Kits) (encoded by TIRAP (show TIRAP ELISA Kits)) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal (show TIRAP ELISA Kits) was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9 (show TLR9 ELISA Kits).
data indicate that increased levels of TLR2 and TLR4 (show TLR4 ELISA Kits) in the liver and spleen may play an important role during acute T. gondii infection
the role of Toll (show TLR4 ELISA Kits)-like receptor (TLR) 2, TLR4 (show TLR4 ELISA Kits), myeloid differentiation response gene 88, and Toll (show TLR4 ELISA Kits)-IL-1 (show IL1A ELISA Kits) receptor domain-containing adaptor-inducing interferon-gamma (show IFNG ELISA Kits) (TRIF (show RNF138 ELISA Kits)), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis.
This study showed that although TLR2 is an important mediator of the early inflammatory response, it is dispensable for protective immunity against O. tsutsugamushi
this study shows an inflammatory role for TLR2 in mouse hepatitis virus-induced acute fulminant hepatitis
these data identify Trim13 (show TRIM13 ELISA Kits) as a positive regulator of NF-kappaB (show NFKB1 ELISA Kits) activation and suggest that lysine 29-linked polyubiquitination is a specific ubiquitin-linked pattern involved in the control of TLR2 signaling.
Transcription levels of TLR2, TLR4 (show TLR4 ELISA Kits), and CD14 (show CD14 ELISA Kits) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 ELISA Kits) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 ELISA Kits) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 ELISA Kits), and TLR6 (show TLR6 ELISA Kits) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 ELISA Kits); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 ELISA Kits) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 ELISA Kits) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
ALOX5AP (show ALOX5AP ELISA Kits), CPNE3 (show CPNE3 ELISA Kits), IL1R2 (show IL1R2 ELISA Kits), IL6 (show IL6 ELISA Kits), TLR2, TLR4 (show TLR4 ELISA Kits), and THY1 (show THY1 ELISA Kits) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 ELISA Kits) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 ELISA Kits) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 ELISA Kits) secretion via the TLR2/MyD88 (show MYD88 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 ELISA Kits) and TLR9 (show TLR9 ELISA Kits) contribute to NF-kappaB (show NFKB1 ELISA Kits) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 ELISA Kits).
Data suggest TLR2, TLR4 (show TLR4 ELISA Kits), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 ELISA Kits).
TLR2 is required for the suppression of TLR4 (show TLR4 ELISA Kits) signaling activation.
The role of TLR2, TLR4 (show TLR4 ELISA Kits) and RP105 (show CD180 ELISA Kits)/MD1 (show LY86 ELISA Kits) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 ELISA Kits), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 ELISA Kits) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 ELISA Kits), TLR2, and TLR6 (show TLR6 ELISA Kits), respectively; in TLR1 (show TLR1 ELISA Kits) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
expression of TLR4 (show TLR4 ELISA Kits) and TLR2 in normal and LPS (show IRF6 ELISA Kits)-treated horses
Because factors other than mastitis can affect SCC (show CYP11A1 ELISA Kits) and our sample sizes were limited, additional studies are needed to corroborate an association between TLR2 genotype and SCC (show CYP11A1 ELISA Kits) or mastitis in goats.
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ ELISA Kits) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 ELISA Kits). burgdorferi through TLR1 (show TLR1 ELISA Kits)/2 and TLR5 (show TLR5 ELISA Kits).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein