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This study suggests that TLR2 and NLRP3 (show NLRP3 ELISA Kits) inflammasomes are factors involved in cross-talk mediating the foreign body type response to wear particles.
Data show that genetic ablation of Toll-like receptor 2 (TLR2) by siRNA and TLR2-neutralizing antibody could block NF-kappa B (NF-kappaB (show NFKB1 ELISA Kits)) activation by exosomes.
TLR2 expression (and TLR9 (show TLR9 ELISA Kits)) is increased in monocyte subsets of active rheumatoid arthritis patients.
TLR-4 (show TLR4 ELISA Kits) might play a more important role than TLR-2 in atherogenesis, especially in acute coronary syndrome.
Altogether, our experiments suggest that histone induces TF expression in ECs via cell surface receptors TLR4 (show TLR4 ELISA Kits) and TLR2, simultaneously depending on the activation of the transcription factors NF-kappaB (show NFKB1 ELISA Kits) and AP-1 (show FOSB ELISA Kits).
This study demonstrates that T597C polymorphism of TLR2 is a risk factor for susceptibility to pulmonary tuberculosis rather than to tuberculous meningitis
This study shows that both TLR2 and TLR9 (show TLR9 ELISA Kits) genes and single nucleotide polymorphism combinations do influence the clinical course of Chlamydia infections.
Meta-analysis/Review: individuals with the rs5743708 gene polymorphism in the TLR2 gene are under a higher risk for tuberculosis disease.
TLR2 and TLR4 (show TLR4 ELISA Kits) gene expression is upregulated when total cholesterol (TC) levels are increased, Triglyceride (TG) levels are increased, or TC and TG are increased.
Median levels of TLR2 mRNA in alveolar echinococcosis and cystic echinococcosis groups were significantly elevated as compared with that in healthy control group
data suggest that Tlr2 deficiency may promote the development of cardiac hypertrophy and ventricular remodeling after transverse aortic constriction
The TLR2 is activated by sporozoites and suppresses intrahepatic rodent malaria parasite development
TLR2 increase the stimulating effect of beta2GP1/anti-beta2GP1 complex on the expression of TNF-alpha (show TNF ELISA Kits) in mouse peritoneal macrophages
Mast cells are able to phagocytose and produce nitric oxide against Candida albicans via TLR2/Dectin-1 (show CLEC7A ELISA Kits).
Severity of sodium dodecyl sulfate-induced colitis is reduced in Ido1 (show IDO1 ELISA Kits)-deficient mice with down-regulation of TLR-MyD88 (show MYD88 ELISA Kits)-NF-kB transcriptional networks.
TLR4 (show TLR4 ELISA Kits), TLR2 also contributed to Mrp8 (show S100A8 ELISA Kits)-induced inflammatory response and tolerance.
This study showed that keratinocyte nicotinic acetylcholine receptors activation dampens TLR2-mediated migration and pro-inflammatory cytokine and antimicrobial peptide (show cAMP ELISA Kits) production.
serine dipeptide lipids of P. gingivalis periodontal pathogen inhibit osteoblast differentiation and function at least in part through engagement of TLR2
HMGB1 (show HMGB1 ELISA Kits)-TLR2/TLR4 (show TLR4 ELISA Kits) signaling cascade.
We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis.
TLR2 and TLR4 (show TLR4 ELISA Kits) mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 (show TLR4 ELISA Kits) with the formation of NETs and change in surface architecture.
TLR2, TLR1 (show TLR1 ELISA Kits), and TLR6 (show TLR6 ELISA Kits) haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4 (show TLR4 ELISA Kits); granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 (show TLR4 ELISA Kits) signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
Whereas previous results regarding the TLR1 (show TLR1 ELISA Kits) gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution.
The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens.
ALOX5AP (show ALOX5AP ELISA Kits), CPNE3 (show CPNE3 ELISA Kits), IL1R2 (show IL1R2 ELISA Kits), IL6 (show IL6 ELISA Kits), TLR2, TLR4 (show TLR4 ELISA Kits), and THY1 (show THY1 ELISA Kits) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This study showed that TLR1 (show TLR1 ELISA Kits) and TLR2 together are necessary for the recognition of triacylated lipopeptides.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 (show TLR4 ELISA Kits) in the ovary.
VB-201 may counter inflammation where TLR-2 and/or CD14 (show CD14 ELISA Kits) complicity is essential, and is therefore beneficial for the treatment of atherosclerosis.
Toll-like receptor 2 signaling on intestinal epithelial cells may enhance intestinal barrier function and prevent deoxynivalenol-induced barrier dysfunction of epithelial cells.
These results suggest that porcine circovirus 2 induces IL-8 (show IL8 ELISA Kits) secretion via the TLR2/MyD88 (show MYD88 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signalling pathway.
At 14 days after autotransplantation of a pig kidney, mRNA expression for TLR2 is increased.
These data demonstrated that TLR2, TLR3 (show TLR3 ELISA Kits) and TLR9 (show TLR9 ELISA Kits) contribute to NF-kappaB (show NFKB1 ELISA Kits) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 ELISA Kits).
Data suggest TLR2, TLR4 (show TLR4 ELISA Kits), and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4 (show TLR4 ELISA Kits).
TLR2 is required for the suppression of TLR4 (show TLR4 ELISA Kits) signaling activation.
The role of TLR2, TLR4 (show TLR4 ELISA Kits) and RP105 (show CD180 ELISA Kits)/MD1 (show LY86 ELISA Kits) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 ELISA Kits), is reported.
Single nucleotide polymorphisms in TLR2 is associated with immune response to gram-negative bacterial infections.
The dramatic reduction in p38 MAPK (show MAPK14 ELISA Kits) phosphorylation by TLR-2 stimulation in aortic valve interstitial cells excludes a role for this receptor type in mediating angiotensin II or peroxynitrite effects.
In total, 20, 27, and 26 SNPs were detected in TLR1 (show TLR1 ELISA Kits), TLR2, and TLR6 (show TLR6 ELISA Kits), respectively; in TLR1 (show TLR1 ELISA Kits) and TLR2, the numbers of SNPs detected were significantly lower (P < or = 0.05, P < or = 0.01) in the wild boars than in the domestic pigs.
expression of TLR4 (show TLR4 ELISA Kits) and TLR2 in normal and LPS (show IRF6 ELISA Kits)-treated horses
Over-expression of TLR2 decreases radical damage to host cells through low-level production of NO and MDA and promotes the clearance of invasive bacteria by up-regulating lysozyme (show LYZ ELISA Kits) secretion and filtration of inflammatory cells to the infected site.
TLR2 of M. fuscata has undergone purifying selection while the membrane-proximal part of the extracellular domain of M. mulatta TLR2 exhibits higher rates of non-synonymous substitutions, indicating a trace of Darwinian positive selection
The results indicate that microglia and astrocytes respond to B (show TDO2 ELISA Kits). burgdorferi through TLR1 (show TLR1 ELISA Kits)/2 and TLR5 (show TLR5 ELISA Kits).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
toll/interleukin 1 receptor-like 4
, toll/interleukin-1 receptor-like protein 4
, toll-like receptor 2 variant 1
, toll-like receptor 2 variant 2
, toll-like receptor 2 type-2
, toll-like receptor 2 type2
, Toll-like receptor 2-like protein