Browse our anti-TLR4 (TLR4) Antibodies

Full name:
anti-Toll-Like Receptor 4 Antibodies (TLR4)
On www.antibodies-online.com are 613 Toll-Like Receptor 4 (TLR4) Antibodies from 38 different suppliers available. Additionally we are shipping TLR4 Kits (58) and TLR4 Proteins (21) and many more products for this protein. A total of 707 TLR4 products are currently listed.
Synonyms:
ARMD10, CD284, Lps, Ly87, Ran/M1, Rasl2-8, TLR-4, TOLL

All available anti-TLR4 Antibodies

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Top referenced anti-TLR4 Antibodies

  1. Cow (Bovine) Polyclonal TLR4 Primary Antibody for IF (cc), IF (p) - ABIN736491 : Tang, Zhou, Wang, Zhang, Wang, Li, Huang: Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts. in Archives of oral biology 2011 (PubMed)
    Show all 10 references for 736491

  2. Mouse (Murine) Polyclonal TLR4 Primary Antibody for WB - ABIN388334 : de Groot, Hoefer, Grundmann, Schoneveld, Haverslag, van Keulen, Bot, Timmers, Piek, Pasterkamp, de Kleijn: Arteriogenesis requires toll-like receptor 2 and 4 expression in bone-marrow derived cells. in Journal of molecular and cellular cardiology 2011 (PubMed)
    Show all 6 references for 388334

  3. Human Polyclonal TLR4 Primary Antibody for DB, EIA - ABIN493502 : Zhang, Shan, Jiang, Cohn, Lee: Toll-like receptor 4 deficiency causes pulmonary emphysema. in The Journal of clinical investigation 2006 (PubMed)
    Show all 5 references for 493502

  4. Mouse (Murine) Monoclonal TLR4 Primary Antibody for FACS, IP - ABIN1449233 : Fuller, Bayley, Chambers: Activin A is an essential cofactor for osteoclast induction. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 4 references for 1449233

  5. Mouse (Murine) Monoclonal TLR4 Primary Antibody for FACS - ABIN1449236 : Kawasaki, Nogawa, Nishijima et al.: Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 ... in Journal of immunology (Baltimore, Md. : 1950) 2002 (PubMed)
    Show all 4 references for 1449236

  6. Human Polyclonal TLR4 Primary Antibody for EIA, WB - ABIN951278 : Sam-Agudu, Greene, Opoka, Kazura, Boivin, Zimmerman, Riedesel, Bergemann, Schimmenti, John: TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. in The American journal of tropical medicine and hygiene 2010 (PubMed)
    Show all 3 references for 951278

  7. Human Monoclonal TLR4 Primary Antibody for FACS - ABIN4896796 : Punsmann, Liebers, Lotz, Brüning, Raulf: Ex vivo cytokine release and pattern recognition receptor expression of subjects exposed to dampness: pilot study to assess the outcome of mould exposure to the innate immune system. in PLoS ONE 2013 (PubMed)
    Show all 2 references for 4896796

  8. Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN119329 : Jiang, Akashi, Miyake, Petty: Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B. in Journal of immunology (Baltimore, Md. : 1950) 2000 (PubMed)
    Show all 2 references for 119329

  9. Mouse (Murine) Monoclonal TLR4 Primary Antibody for FACS - ABIN4897001 : Wang, Ma, Charboneau, Barke, Roy: Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. in The Journal of biological chemistry 2011 (PubMed)

  10. Human Monoclonal TLR4 Primary Antibody for FACS - ABIN4896792 : Donnadieu-Rigole, Mura, Portales, Duroux-Richard, Bouthier, Eliaou, Perney, Apparailly: Effects of alcohol withdrawal on monocyte subset defects in chronic alcohol users. in Journal of leukocyte biology 2016 (PubMed)

More Antibodies against TLR4 Interaction Partners

Human Toll-Like Receptor 4 (TLR4) interaction partners

  1. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS(-/-) and TLR4(-/-) cells.

  2. Here the authors show that MAL (show MAL Antibodies) TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 TIR domains and induce formation of MyD88 (show MYD88 Antibodies) assemblies.

  3. Experiments demonstrate for the first time that palmitic acid activation of TLR4 occurs in response to direct molecular interactions between palmitic acid and MD-2 (show LY96 Antibodies); suggest a likely molecular mechanism for palmitic acid induction of pro-inflammatory immune responses in human dendritic cells expressing TLR4.

  4. In LPS-stimulated HEK293 cells with low CD14 and high (show IRF6 Antibodies) TLR4, no accumulation of PI(4,5)P2 occurred. With an increasing amount of CD14 and decrease of TLR4, 2 peaks of PI(4,5)P2 appeared, approaching those found in LPS-stimulated cells expressing CD14 alone. This suggests that LPS-induced accumulation of PI(4,5)P2 that maximizes TLR4 signaling is controlled by CD14, whereas TLR4 can fine tune this via PI(4,5)P2 turnover.

  5. TLR4 coding SNPs Asp299Gly and Thr399Ile might be used as genetic susceptibility alleles for POAG

  6. Estradiol alters the immune-responsiveness of cultured HECECs to TLR2 (show TLR2 Antibodies) and TLR4 ligands in a complex fashion that appears to vary with bacterial ligand, TLR subtype, and duration of exposure

  7. Ligand-driven triggering of TLR-3 (show TLR3 Antibodies), -4, NOD2 (show NOD2 Antibodies), and DC-SIGN (show CD209 Antibodies), despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells.

  8. The study demonstrated that HIV infection sensitizes Kupffer cells to the proinflammatory effects of lipopolysaccharides in a TLR4-dependent manner.

  9. The lipid flippases, ATP8B1 (show ATP8B1 Antibodies) and ATP11A (show ATP11A Antibodies) are novel elements of the innate immune response that are essential to attenuate the inflammatory response, possibly by mediating endotoxin-induced internalization of TLR4.

  10. these findings identify new compounds for antagonizing TLR2 (show TLR2 Antibodies) and TLR4 activation and define structural properties of POPG analogs for discriminating between two TLR systems.

Mouse (Murine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. Stimulation of the TLR4-TRIF (show RNF138 Antibodies) pathway can protect against the development of allergic airway disease and that a TRIF (show RNF138 Antibodies)-dependent adjuvant effect on CD4 (show CD4 Antibodies)(+) ICOS (show ICOS Antibodies)(+) T-cell responses may be a contributing mechanism.

  2. HMGB1 (show HMGB1 Antibodies) activates the NF-kappaB (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies) pathways through TLR4/MyD88 (show MYD88 Antibodies)-dependent signaling and induces an inflammatory response in lungs exposed to cigarette smoke.

  3. Findings reveal that TLR4 mutant significantly abated the intestinal IR injury and ALI at least in part by alleviating the inflammatory response and oxidative stress.

  4. These findings indicate that TLR2 (show TLR2 Antibodies) and TLR4 are required to control Brucella microti infection in mice and that this effect could be related to its participation in the maturation of dendritic cells and the generation of specific CD8 (show CD8A Antibodies)(+) Tc cells.

  5. Monophosphoryl lipid A stimulation of a TLR4-TRIF (show RNF138 Antibodies)-PI3K-Akt (show AKT1 Antibodies) pathway prevents lipopolysaccharide-induced ERK (show EPHB2 Antibodies) activation in the medullar thick ascending limb.

  6. Results show that TLR4 plays a critical role in the effects of dietary fat composition on the development of hepatic steatosis, inflammation, and injury consistent with nonalcoholic steatohepatitis.

  7. FasL (show FASL Antibodies) expression in splenic CD5 (show CD5 Antibodies)(+)CD1d (show CD1D Antibodies)(hi) B cells was decreased compared to the control group after TLR4 ligation.

  8. Stimulation of murine peritoneal macrophages with LPS induces biphasic accumulation of PI(4,5)P2 with peaks at 10 and 60-90 min that were still seen after silencing of TLR4 expression, questioning the involvement of TLR4 in this process.

  9. Data suggest that the transmembrane domains of Tlr4 and Tlr6 (show TLR6 Antibodies) have essential roles in Tlr4/Tlr6 (show TLR6 Antibodies)/Cd36 (show CD36 Antibodies) receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.

  10. This study demonstrated that TLR4 deficiency contributes to regulating microglia to switch to the M2 phenotype, which ameliorates neurological impairment after traumatic brain injury in mice.

Cow (Bovine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. TLR4 polymorphisms are associated with lower reproductive Performance.

  2. As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Antibodies) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.

  3. Transcription levels of TLR2 (show TLR2 Antibodies), TLR4, and CD14 (show CD14 Antibodies) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.

  4. Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.

  5. TLR2 (show TLR2 Antibodies) and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.

  6. TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins

  7. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 (show TLR2 Antibodies) and TLR4 with the formation of NETs and change in surface architecture.

  8. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Antibodies)) genes.

  9. Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.

  10. Findings indicate that intervertebral disc (IVD (show IVD Antibodies)) cells constitutively express TLR4.

Rabbit Toll-Like Receptor 4 (TLR4) interaction partners

  1. TLR2 (show TLR2 Antibodies), 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

  2. The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Antibodies) (p65 (show SYT1 Antibodies)) were respectively detected.

  3. Lipopolysaccharide upregulates the expression of rabbit TLR2 (show TLR2 Antibodies) and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.

  4. Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Antibodies) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Antibodies).

  5. TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage

  6. The elevated expression of TLR4 was detected after SAH (show ACSM3 Antibodies) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Antibodies).

Pig (Porcine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Antibodies) in Meishan weaned piglets.

  2. Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Antibodies) challenge.

  3. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.

  4. Data suggest TLR2 (show TLR2 Antibodies), TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2 (show TLR2 Antibodies)/TLR4.

  5. TLR2 (show TLR2 Antibodies) is required for the suppression of TLR4 signaling activation.

  6. The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.

  7. The role of TLR2 (show TLR2 Antibodies), TLR4 and RP105 (show CD180 Antibodies)/MD1 (show LY86 Antibodies) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Antibodies), is reported.

  8. Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.

  9. Fish Oil attenuates the activation of the HPA (show HPSE Antibodies) axis induced by LPS (show IRF6 Antibodies) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.

  10. Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.

Horse (Equine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.

  2. A low steady expression of TLR4, MD-2 (show LY96 Antibodies) and CD14 (show CD14 Antibodies) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.

  3. In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.

  4. evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins

  5. TLR4/MD-2 (show LY96 Antibodies) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.

TLR4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TLR4

  • toll-like receptor 4 (TLR4) antibody
  • toll-like receptor 4 (Tlr4) antibody
  • ARMD10 antibody
  • CD284 antibody
  • Lps antibody
  • Ly87 antibody
  • Ran/M1 antibody
  • Rasl2-8 antibody
  • TLR-4 antibody
  • TOLL antibody

Protein level used designations for TLR4

hToll , homolog of Drosophila toll , lipopolysaccharide response , toll4 , Toll-like receptor4 protein , Toll-like receptor 4-like protein

GENE ID SPECIES
7099 Homo sapiens
21898 Mus musculus
417241 Gallus gallus
29260 Rattus norvegicus
281536 Bos taurus
100009497 Oryctolagus cuniculus
100724803 Cavia porcellus
403417 Canis lupus familiaris
399541 Sus scrofa
493698 Felis catus
100066890 Equus caballus
100860955 Capra hircus
554263 Ovis aries
100980644 Pan paniscus
100689329 Cricetulus griseus
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