Browse our TLR4 Proteins (TLR4)

Full name:
Toll-Like Receptor 4 Proteins (TLR4)
On www.antibodies-online.com are 21 Toll-Like Receptor 4 (TLR4) Proteins from 8 different suppliers available. Additionally we are shipping TLR4 Antibodies (607) and TLR4 Kits (54) and many more products for this protein. A total of 697 TLR4 products are currently listed.
Synonyms:
ARMD10, CD284, Lps, Ly87, Ran/M1, Rasl2-8, TLR-4, TOLL
list all proteins Gene Name GeneID UniProt
TLR4 7099 O00206
TLR4 21898 Q9QUK6
TLR4 29260 Q9QX05

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TLR4 Proteins (TLR4) by Origin

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Top referenced TLR4 Proteins

  1. Human TLR4 Protein expressed in Wheat germ - ABIN1322876 : Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008 (PubMed)
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More Proteins for TLR4 Interaction Partners

Human Toll-Like Receptor 4 (TLR4) interaction partners

  1. these findings identify new compounds for antagonizing TLR2 and TLR4 activation and define structural properties of POPG analogs for discriminating between two TLR systems.

  2. Compared to adipocytes from the infrapatellar fat pad (show PADI4 Proteins) (IPFP) and synovium of lean patients, adipocytes from the IPFP of obese patients had higher levels of TLR4 gene expression.

  3. These new findings reveal the ability of RvD2 to reduce TLR4 expression and attenuate LPS (show IRF6 Proteins)-induced inflammation, providing a new area of SPM (show NPC1 Proteins) activity to investigate in this major area of therapeutic research.

  4. The present study demonstrated that plasma fatty acid can interact with variants of the TLR4 gene to modulate the risk for a systemic inflammatory state represented by the inflammatory cluster, as measured by 11 inflammatory biomarker plasma concentrations.

  5. Smoking can induce differential expression of circulating miR (show MLXIP Proteins)-NAs (show SCN9A Proteins), such as down-regulation of miR (show MLXIP Proteins)-149-3p. Reducing miR (show MLXIP Proteins)-149-3p may increase the inflammatory response in COPD (show ARCN1 Proteins) patients through the regulation of the TLR-4/NF-kappaB (show NFKB1 Proteins) signaling pathway

  6. HDL (show HSD11B1 Proteins) isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP (show DDIT3 Proteins) upregulation, which were blocked by PBA and DPI. These data indicate that ox-HDL (show HSD11B1 Proteins) may activate ER stress-CHOP (show DDIT3 Proteins)-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4.

  7. The current study discovered a novel 72-kDa chondroitin sulfate-OGN (show OGN Proteins) that is specific for innate immune cells. This variant is able to bind and activate TLR4.

  8. the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 (show PTPN22 Proteins) c.1858C>T (rs2476601), TLR4 c.896A>G (rs4986790) and TLR4 c.1196C>T (rs4986791), IL7R (show IL7R Proteins) c.197T>C (rs1494555) and IL7R (show IL7R Proteins) c.412G>A (rs1494558).

  9. This study suggest that TLR4 gene polymorphism may act as an intermediate factor for the association between tobacco smoking addiction and bipolar disorder.

  10. On stimulation with the TLR4 agonist, LPS (show IRF6 Proteins) downregulated TLR4 mRNA expression in alveolar macrophages.

Mouse (Murine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. Data suggest that the transmembrane domains of Tlr4 and Tlr6 (show TLR6 Proteins) have essential roles in Tlr4/Tlr6 (show TLR6 Proteins)/Cd36 (show CD36 Proteins) receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.

  2. This study demonstrated that TLR4 deficiency contributes to regulating microglia to switch to the M2 phenotype, which ameliorates neurological impairment after traumatic brain injury in mice.

  3. Ggut dysbiosis with simultaneous leaky gut (show GUSB Proteins) and systemic endotoxemia-induced TLR4 activation.

  4. The current study discovered a novel 72-kDa chondroitin sulfate-OGN (show OGN Proteins) that is specific for innate immune cells. This variant is able to bind and activate TLR4.

  5. results strongly implicate the HMGB1-TLR2/4 axis in the activation of microglia following multiple cortical spreading depression inductions

  6. Inflammatory polarization of cardiac mesenchymal stromal cells by left ventricular dysfunction is mediated by TLR4.

  7. TLR4 signaling mediates benzanthrone-induced inflammation.

  8. These findings illustrate the critical role of pulmonary TLR4 in the development of necrotizing enterocolitis -associated lung injury

  9. TRIF (show RNF138 Proteins) has a central role in sterile liver injury in mouse model.

  10. IL-10 (show IL10 Proteins) helps to maintain heart function during stress via myeloid differentiation gene 88/IRAK-4 (show IRAK4 Proteins)/IRAK-1 (show IRAK1 Proteins)-dependent TLR4 signaling.

Cow (Bovine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. TLR4 polymorphisms are associated with lower reproductive Performance.

  2. As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Proteins) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.

  3. Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.

  4. Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.

  5. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.

  6. TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins

  7. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.

  8. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Proteins)) genes.

  9. Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.

  10. Findings indicate that intervertebral disc (IVD (show IVD Proteins)) cells constitutively express TLR4.

Rabbit Toll-Like Receptor 4 (TLR4) interaction partners

  1. TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

  2. The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.

  3. Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.

  4. Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).

  5. TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage

  6. The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).

Pig (Porcine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.

  2. Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.

  3. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.

  4. Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.

  5. TLR2 is required for the suppression of TLR4 signaling activation.

  6. The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.

  7. The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.

  8. Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.

  9. Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.

  10. Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.

Horse (Equine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.

  2. A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.

  3. In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.

  4. evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins

  5. TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.

TLR4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TLR4

  • toll-like receptor 4 (TLR4)
  • toll-like receptor 4 (Tlr4)
  • ARMD10 protein
  • CD284 protein
  • Lps protein
  • Ly87 protein
  • Ran/M1 protein
  • Rasl2-8 protein
  • TLR-4 protein
  • TOLL protein

Protein level used designations for Toll-Like Receptor 4 Proteins (TLR4)

hToll , homolog of Drosophila toll , lipopolysaccharide response , toll4 , Toll-like receptor4 protein , Toll-like receptor 4-like protein

GENE ID SPECIES
7099 Homo sapiens
21898 Mus musculus
417241 Gallus gallus
29260 Rattus norvegicus
281536 Bos taurus
100009497 Oryctolagus cuniculus
100724803 Cavia porcellus
403417 Canis lupus familiaris
399541 Sus scrofa
493698 Felis catus
100066890 Equus caballus
100860955 Capra hircus
554263 Ovis aries
100980644 Pan paniscus
100689329 Cricetulus griseus
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