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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
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These results show that DC-SIGN (show CD209 Proteins) and TLR-4 interactions regulate inflammatory responses in renal tubular epithelial cells and participate in AKI pathogenesis.
Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin (show OCLN Proteins) and zonula occludens 1 (show TJP1 Proteins).
Data show that TLR4 was the miR (show MLXIP Proteins)-511-5p direct target responsible for glucocorticoids- and TGF-beta (show TGFB1 Proteins)-mediated inhibition of pro-inflammatory cytokines production observed in endotoxin tolerant monocytes.
TLR3 (show TLR3 Proteins) or TLR4 activation of mesenchymal stem cells increases Treg cell induction via the Notch (show NOTCH1 Proteins) pathway
Taxol activates the TLR4-NFkappaB (show NFKB1 Proteins) pathway which in turn induces ABCB1 (show ABCB1 Proteins) gene expression and drug resistance in ovarian carcinoma cells.
miR (show MLXIP Proteins)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4, TRAF6 (show TRAF6 Proteins), and p-IkappaBalpha (show NFKBIA Proteins), subsequently leading to decreased NF-kappaB (show NFKB1 Proteins) p65 (show GORASP1 Proteins) nuclear translocation.
ITGalpha4beta1 and TLR4 have roles in inducing fibrotic gene expression in response to fibronectin's EDA (show EDA Proteins) domain
our study suggested that both death receptors and mitochondial were involved in TLR4-induced cell death, and TAP63alpha may be a target for the prevention of LPS (show IRF6 Proteins)-induced cell death.
Expression of TLR4/MD2 (show LY96 Proteins)/CD14 (show NDUFA2 Proteins) is required for casein alpha S1 (show CSN1S1 Proteins)-induced proinflammatory effects. TLR4 blockade inhibits casein alpha S1 (show CSN1S1 Proteins) induced proinflammatory cytokine expression.
This study investigated the effects of DYN 3-14 on lipopolysaccharide (LPS (show IRF6 Proteins))-induced nuclear factor-kappaB/p65 (NF-kappaB/p65 (show NFkBP65 Proteins)) nuclear translocation.These findings indicate that DYN 3-14 is a potential TLR4 antagonist that alters cellular signaling in response to LPS (show IRF6 Proteins) and cytokine release, implicating a role for biotransformed endogenous opioid peptides in immunomodulation.
Data suggest that dietary treatment with green tea extract reduces hepatic inflammation in non-alcoholic fatty liver disease by decreasing proinflammatory signaling in liver through Tnfr1 (show TNFRSF1A Proteins) (tumor necrosis factor (show TNF Proteins) receptor superfamily, member 1a) and Tlr4 (toll-like receptor 4) that otherwise increases NFkappaB activation and liver injury.
TLR4-MyD88 (show MYD88 Proteins) expression on B1a cells is critical for their IgM (show CD40LG Proteins)-dependent atheroprotection that not only reduced lesion apoptotic cells and necrotic cores, but also decreased CD4 (show CD4 Proteins) and CD8 (show CD8A Proteins) T-cell infiltrates and augmented TGF-beta1 (show TGFB1 Proteins) expression accompanied by reduced lesion inflammatory cytokines TNF-alpha (show TNF Proteins), IL-1beta (show IL1B Proteins), and IL-18 (show IL18 Proteins).
Results suggested that TLR4 is essential in mediating host leptospiral clearance and, to some extent, is associated with pulmonary and subcutaneous hemorrhage, probably through downstream inflammatory mediators, iNOS (show NOS2 Proteins) in particular.
Data show that TLR4-mediated up-regulation of Blimp-1 (show PRDM1 Proteins) led to the down-regulation of NLRP12 (show NLRP12 Proteins) expression in dextran sulfate sodium (DSS (show PMP22 Proteins))-induced colitis.
Artificially applied c-kit(+) cells interact with the target organ endothelium following ischemia reperfusion injury. This interaction seems to depend on TLR-MyD88 (show MYD88 Proteins) signaling.
Quercetin reverted gut (show GUSB Proteins) microbiota imbalance and related endotoxemia-mediated TLR-4 pathway induction, with subsequent inhibition of inflammasome response and reticulum stress pathway activation, leading to the blockage of lipid metabolism gene expression deregulation.
Soyasaponin Bb can inhibit TLR4 recruitment into lipid rafts and its signaling by suppressing the NADPH oxidase (show NOX1 Proteins)-dependent reactive oxygen species generation.
TLR4 signaling was essential for the induction of antigen-specific Th1 (show HAND1 Proteins) immune responses elicited by OMLs.
Inhibition of TLR4 ameliorates AngII-impaired cavernosal relaxation, decreases TNF-alpha (show TNF Proteins) levels, and restores Nitric Oxide bioavailability, demonstrating that TLR4 partly mediates AngII-induced cavernosal dysfunction.
STA3 (show ARHGEF3 Proteins) facilitates TLR4-dependent IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) production via IL-6 (show IL6 Proteins) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Proteins) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Proteins)) genes.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein