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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
Show all 2 references for ABIN1322876
The presence of polymorphism of the TLR4 gene in the genome can be considered as a predictor of development of chronic hepatitis C
Children with respiratory syncytial virus infection had lower TLR4 mRNA levels in peripheral blood mononuclear cells.
These findings indicate that rs11536889 in TLR4 might be specifically associated with prostate cancer
TLR4 may promote cholesteatoma-induced bone destruction and deafness by enhancing inflammatory responses and osteoclastogenesis.
Therefore, TLR4 agonists like GLA (show NAT8 Proteins) are particularly promising candidates as adjuvants of vaccines designed for elderly individuals.
Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-alpha (show TNF Proteins) G-308A, IL-6 (show IL6 Proteins) G-174C and IL-1RN (show IL1RN Proteins) VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN (show IL1RN Proteins) VNTR A2 variants.
Study describes evidence for the role of HMGB1 (show HMGB1 Proteins)-RAGE (show AGER Proteins) and the HMGB1 (show HMGB1 Proteins)-TLR4 axis associated with pulmonary dysfunction and central nervous system injury. [review]
TLR-4 expression levels were higher in patients with acute coronary syndrome (ACS) than in patients with stable angina. TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS.
Altogether, our experiments suggest that histone induces TF expression in ECs via cell surface receptors TLR4 and TLR2, simultaneously depending on the activation of the transcription factors NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins).
That siRNA delivery resulted in efficient protein knockdown of toll-like receptor 4 (TLR4).
Attenuated inflammation through down-regulating the levels of MyD88 (show MYD88 Proteins) by decreasing TLR4 expression.
HMGB1 (show HMGB1 Proteins) promotes the pathogenesis of pancreatitis, and its downstream TLR4-mediated NF-kappaB (show NFKB1 Proteins) signaling pathway is a potential important mediator in the development of this form of pancreatic injury.
results support a novel function of TLR4 in regulating the development of PAH and reveal a new regulatory axis contributing to TLR4 deficiency-induced vascular hypertrophy and remodeling
Thus, bleomycin-induced pulmonary fibrosis is TLR4-dependent and TLR4 promoted fibrosis in bleomycin-challenged mice
TLR4 knockout protects mice from middle cerebral artery occlusion damage, but to a lesser extent than hyperbaric oxygen treatment
TLR4, TLR2 also contributed to Mrp8 (show S100A8 Proteins)-induced inflammatory response and tolerance.
TRIF (show RNF138 Proteins)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 and 3. JNK (show MAPK8 Proteins)-dependent mechanisms likely mediate this downregulation.
Results show that toll/IL-1 (show IL1A Proteins) domain-containing adaptor inducing IFN-beta (show IFNB1 Proteins) (TRIF (show RNF138 Proteins)) is essential for Toll-like receptors TLR3 (show TLR3 Proteins)- and TLR4-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
mouse urothelium responds to the adhesion of type 1-fimbriated UPEC by activating dual ligand/receptor system, one between FimH adhesin and uroplakin Ia and another between lipopolysaccharide and Tlr4.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Proteins)) genes.
Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.
Findings indicate that intervertebral disc (IVD (show IVD Proteins)) cells constitutively express TLR4.
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
TLR4 and downstream adaptor molecules, transcription factors and cytokines were up-regulated when endometrial epithelial cells were stimulated with LPS (show IRF6 Proteins)
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The complete coding sequence of TLR4 gene in Min pig and 3 variants with single point mutations were obtained.
A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein