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Browse our TLR4 Proteins (TLR4)

Full name:
Toll-Like Receptor 4 Proteins (TLR4)
On www.antibodies-online.com are 21 Toll-Like Receptor 4 (TLR4) Proteins from 8 different suppliers available. Additionally we are shipping TLR4 Antibodies (603) and TLR4 Kits (50) and many more products for this protein. A total of 689 TLR4 products are currently listed.
Synonyms:
ARMD10, CD284, Lps, Ly87, Ran/M1, Rasl2-8, TLR-4, TOLL
list all proteins Gene Name GeneID UniProt
TLR4 7099 O00206
TLR4 21898 Q9QUK6
TLR4 29260 Q9QX05

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TLR4 Proteins (TLR4) by Origin

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Top referenced TLR4 Proteins

  1. Human TLR4 Protein expressed in Wheat germ - ABIN1322876 : Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008 (PubMed)
    Show all 2 references for ABIN1322876

More Proteins for TLR4 Interaction Partners

Human Toll-Like Receptor 4 (TLR4) interaction partners

  1. This study evaluated the relationship between 11 SNPs of TLR2 and TLR4 and clinical parameters and genetic risk factors for psoriasis vulgaris in a cohort from southern China.

  2. Our observations suggest that exposure of macrophages to Gram-negative bacteria influence the establishment and maintenance of HIV persistence in macrophages through a TLR4-dependent mechanism.

  3. Patients with CD14 C (-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development.

  4. Higher expression of TLR4 and KLF7 (show KLF7 Proteins) may play a vital role in the process of inflammation induced by obesity in visceral adipose tissue

  5. higher TLR4 levels in the early stage of aneurysmal subarachnoid hemorrhage is also associated with the neurological function outcome

  6. TLR4 may play an important role in atherosclerosis and could be a potential therapeutic target for treatment of coronary artery disease.

  7. the increased expression of TLR4 in the responsiveness of LPS (show IRF6 Proteins)-treated THP1 cells occurred in response to the upregulation of their respective receptors, as well as a tight binding of NF-kappaB (show NFKB1 Proteins) in the TLR4 gene promoter.

  8. analysis of TLR2, TLR4 and TLR9 (show TLR9 Proteins) genes and their significance as biological markers in patients with B-cell chronic lymphocytic leukemia

  9. We found lower expression levels of TLR1 (show TLR1 Proteins), TLR3 (show TLR3 Proteins), TLR4, TLR7 (show TLR7 Proteins) and TLR9 (show TLR9 Proteins) in PBMCs from patients with ALL compared with those from control patients. We also observed that the PBMCs from patients with Pre-B and B ALL had lower TLR4 expression than controls

  10. TLR-stimulated pancreatic cancer cells were specifically investigated for activated signaling pathways of VEGF (show VEGFA Proteins)/PDGF (show PDGFA Proteins) and anti-apoptotic Bcl-xL (show BCL2L1 Proteins) expression as well as tumor cell growth.

Mouse (Murine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. this study shows that TLR4-dependent, M1 macrophage trafficking/polarization into the CNS as a key mechanistic link between acute traumatic brain injury and long-term, adaptive immune responses

  2. We conclude that upon ligand binding, TLR4 activates PI3K/Akt (show AKT1 Proteins) signaling to induce F-spondin (show SPON1 Proteins) expression, subsequently control CREB (show CREB1 Proteins)-mediated IL-6 (show IL6 Proteins) production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin (show SPON1 Proteins) in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis.

  3. inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling

  4. Chotosan can ameliorate Abeta1-2-induced memory dysfunction via inhibiting neuroinflammation and apoptosis at least partially mediated by TLR-4/NF-kappaB (show NFKB1 Proteins) signaling pathway.

  5. Toll-Like Receptor 4/MyD88 (show MYD88 Proteins)-Mediated Signaling of Hepcidin (show HAMP Proteins) Expression Causing Brain Iron Accumulation

  6. The TLR4-HMGB1 signaling pathway affects the process of autoimmune myositis inflammation by regulating the expression of MHC-I and other pro-inflammatory cytokines

  7. Orally administered poncirin is metabolized to ponciretin by gut (show GUSB Proteins) microbiota and poncirin and ponciretin attenuates colitis by suppressing NF-kappaB (show NFKB1 Proteins) activation through the inhibition of LPS binding on macrophages and correcting Th17/Treg cell imbalance.

  8. this study shows that Tlr4 can regulate inflammation through regulation of generation of reactive oxygen species in in Aspergillus fumigatus keratitis

  9. These findings suggest that extracellular Prx1 (show PRDX1 Proteins)-mediated TLR4/NF-kappaB (show NFKB1 Proteins) pathway activation probably contributes to neuroinflammatory injury after ICH (show ACE Proteins), and thus blocking Prx1 (show PRDX1 Proteins)-TLR4 signaling might provide a novel anti-neuroinflammatory strategy with extended therapeutic window for hemorrhagic stroke

  10. Results showed that ulinastatin (show AMBP Proteins) protected the brain against ischemic injury which may be due to the alleviation of inflammation reaction in early stage through downregulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression

Cow (Bovine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.

  2. Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.

  3. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.

  4. TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins

  5. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.

  6. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Proteins)) genes.

  7. Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.

  8. Findings indicate that intervertebral disc (IVD (show IVD Proteins)) cells constitutively express TLR4.

  9. Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways.

  10. The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.

Rabbit Toll-Like Receptor 4 (TLR4) interaction partners

  1. The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.

  2. Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.

  3. Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).

  4. TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage

  5. The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).

Pig (Porcine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.

  2. Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.

  3. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.

  4. Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.

  5. TLR2 is required for the suppression of TLR4 signaling activation.

  6. The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.

  7. The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.

  8. Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.

  9. Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.

  10. Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.

Horse (Equine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.

  2. A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.

  3. In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.

  4. evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins

  5. TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.

TLR4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TLR4

  • toll-like receptor 4 (TLR4)
  • toll-like receptor 4 (Tlr4)
  • ARMD10 protein
  • CD284 protein
  • Lps protein
  • Ly87 protein
  • Ran/M1 protein
  • Rasl2-8 protein
  • TLR-4 protein
  • TOLL protein

Protein level used designations for Toll-Like Receptor 4 Proteins (TLR4)

hToll , homolog of Drosophila toll , lipopolysaccharide response , toll4 , Toll-like receptor4 protein , Toll-like receptor 4-like protein

GENE ID SPECIES
7099 Homo sapiens
21898 Mus musculus
417241 Gallus gallus
29260 Rattus norvegicus
281536 Bos taurus
100009497 Oryctolagus cuniculus
100724803 Cavia porcellus
403417 Canis lupus familiaris
399541 Sus scrofa
493698 Felis catus
100066890 Equus caballus
100860955 Capra hircus
554263 Ovis aries
100980644 Pan paniscus
100689329 Cricetulus griseus
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