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Browse our TLR4 Proteins (TLR4)

Full name:
Toll-Like Receptor 4 Proteins (TLR4)
On www.antibodies-online.com are 21 Toll-Like Receptor 4 (TLR4) Proteins from 8 different suppliers available. Additionally we are shipping TLR4 Antibodies (602) and TLR4 Kits (54) and many more products for this protein. A total of 692 TLR4 products are currently listed.
Synonyms:
ARMD10, CD284, Lps, Ly87, Ran/M1, Rasl2-8, TLR-4, TOLL
list all proteins Gene Name GeneID UniProt
TLR4 7099 O00206
TLR4 21898 Q9QUK6
TLR4 29260 Q9QX05

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TLR4 Proteins (TLR4) by Origin

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Top referenced TLR4 Proteins

  1. Human TLR4 Protein expressed in Wheat germ - ABIN1322876 : Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008 (PubMed)
    Show all 2 references for ABIN1322876

More Proteins for TLR4 Interaction Partners

Human Toll-Like Receptor 4 (TLR4) interaction partners

  1. S100A8 (show S100A8 Proteins) and S100A9 (show S100A9 Proteins) proteins in concentrations secreted by CD34 (show CD34 Proteins)(-)/CD31 (show HBA1 Proteins)(+) circulating angiogenic cells (CACs) with impaired function reduce endothelial cell capillary-like network formation. These effects appear to be mediated by Toll-like receptor 4 and are absent with S100A8 (show S100A8 Proteins) and S100A9 (show S100A9 Proteins) in concentrations secreted by healthy CD34 (show CD34 Proteins)(-)/CD31 (show HBA1 Proteins)(+) CACs.

  2. The results provided evidence of an association between the TLR4 rs10116253 in the promoter region and a reduced risk of coronary artery disease.

  3. TLR2 priming (via Pam3Csk4) would inhibit TLR4-mediated responses while TLR3 (show TLR3 Proteins) priming (via Poly I:C) would enhance subsequent TLR4-inflammatory signaling.

  4. The results suggest significant associations between RA and JIA disease susceptibility and TLR4 SNPs in a set of RA and JIA patients and healthy individuals in central south Chinese Han population.

  5. These studies identify TGFbeta2-TLR4 crosstalk as a novel pathway involved in ECM (show MMRN1 Proteins) regulation in the TM and ocular hypertension.

  6. TLR4 signaling in HMGB1 (show HMGB1 Proteins) mediated the suppressive function of Treg cells through the activation of the NF-kappaB (show NFKB1 Proteins) pathway.

  7. In patients with cutaneous leishmaniasis, the A allele in TNFalpha (show TNF Proteins)-308G/A SNP was found more frequently in individuals with asymptomatic infection (16% vs 7%), whereas the CC genotype in IL-10 (show IL10 Proteins)-819 C/T SNP was more frequent in patients with chronic disease (34% vs. 27% in asymptomatic individuals). No differences in allele frequencies for TLR4 SNPs were found among groups.

  8. TLR4 is an innate immunity receptor which plays a pathogenic role during chronic inflammation and can induce hepatocellular carcinoma in humans

  9. our data showed the contribution on the TLR4+896A/G and CD14 (show NDUFA2 Proteins)-159C/T polymorphism-related immune dysfunction including increased non-classical (inflammatory) monocyte proportion-related LPS (show IRF6 Proteins) hyper-inflammatory response and decreased classical (phagocytic) monocyte proportion-related impaired phagocytosis in febrile acute de-compensated cirrhotic patients complicated with severe sepsis.

  10. 1,25D3 causes ectodomain shedding of TLR4 and thereby decreases the responsiveness of cells to LPS (show IRF6 Proteins). ADAM10 (show ADAM10 Proteins), activated by extracellular Ca2 (show CA2 Proteins)+ influx, was implicated in the ectodomain cleavage of TLR4.

Mouse (Murine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

  2. The mRNA expression of TLR4 and NF-kappaB (show NFKB1 Proteins) is increased in a neonatal murine model of necrotizing enterocolitis.

  3. melatonin could inhibit TLR4 expression in hypoxic microglia followed by suppression of caspase3 activation leading to decrease in production of proinflammatory mediators

  4. Data provide strong evidence that TLR4 mediates irinotecan-induced gut (show GUSB Proteins) toxicity and pain.

  5. We conclude that TLR4 is an upstream regulator of insulin (show INS Proteins) sensitivity, while partly upregulating muscle ceramides and worsening mitochondrial respiration during 2 wk of HU.

  6. results demonstrated that HDL (show HSD11B1 Proteins) and apoA-I (show APOA1 Proteins) reduced palmitate-potentiated TLR4 trafficking into lipid rafts and its related inflammation in adipocytes via these specific transporters

  7. this study shows that direct stimulation of B cells by LPS via TLR4 is necessary and sufficient to induce B cells to produce IgM in vivo without help from non-B cells

  8. LPS increased expression of inflammatory cytokines on the ocular surface. This expression was further increased in dry eye, which suggests that epithelial barrier disruption enhances exposure of LPS to TLR4+ cells and that the inflammatory response to endotoxin-producing commensal or pathogenic bacteria may be more severe in dry eye disease.

  9. Results suggest that TLR4-dependent claudin-1 (show CLDN1 Proteins) internalization and secondary anion secretion contribute to irinotecan-induced diarrhea.

  10. HHcy promotes TLR-4-driven chronic vascular inflammation.

Cow (Bovine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. TLR4 polymorphisms are associated with lower reproductive Performance.

  2. As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Proteins) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.

  3. Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.

  4. Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.

  5. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.

  6. TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins

  7. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.

  8. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Proteins)) genes.

  9. Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.

  10. Findings indicate that intervertebral disc (IVD (show IVD Proteins)) cells constitutively express TLR4.

Rabbit Toll-Like Receptor 4 (TLR4) interaction partners

  1. TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.

  2. The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.

  3. Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.

  4. Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).

  5. TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage

  6. The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).

Pig (Porcine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.

  2. Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.

  3. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.

  4. Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.

  5. TLR2 is required for the suppression of TLR4 signaling activation.

  6. The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.

  7. The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.

  8. Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.

  9. Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.

  10. Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.

Horse (Equine) Toll-Like Receptor 4 (TLR4) interaction partners

  1. The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.

  2. A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.

  3. In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.

  4. evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins

  5. TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.

TLR4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TLR4

  • toll-like receptor 4 (TLR4)
  • toll-like receptor 4 (Tlr4)
  • ARMD10 protein
  • CD284 protein
  • Lps protein
  • Ly87 protein
  • Ran/M1 protein
  • Rasl2-8 protein
  • TLR-4 protein
  • TOLL protein

Protein level used designations for Toll-Like Receptor 4 Proteins (TLR4)

hToll , homolog of Drosophila toll , lipopolysaccharide response , toll4 , Toll-like receptor4 protein , Toll-like receptor 4-like protein

GENE ID SPECIES
7099 Homo sapiens
21898 Mus musculus
417241 Gallus gallus
29260 Rattus norvegicus
281536 Bos taurus
100009497 Oryctolagus cuniculus
100724803 Cavia porcellus
403417 Canis lupus familiaris
399541 Sus scrofa
493698 Felis catus
100066890 Equus caballus
100860955 Capra hircus
554263 Ovis aries
100980644 Pan paniscus
100689329 Cricetulus griseus
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