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Human Monoclonal DNM2 Primary Antibody for IF, IP - ABIN967865
Cook, Urrutia, McNiven: Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 5 Pubmed References
Human Monoclonal DNM2 Primary Antibody for IF, IP - ABIN967866
Kessels, Engqvist-Goldstein, Drubin: Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation. in Molecular biology of the cell 2000
Show all 5 Pubmed References
Human Polyclonal DNM2 Primary Antibody for WB - ABIN152770
McNiven: Dynamin: a molecular motor with pinchase action. in Cell 1998
Show all 4 Pubmed References
Human Monoclonal DNM2 Primary Antibody for IHC (fro), IHC (p) - ABIN3073353
Quan, Robinson: Rapid purification of native dynamin I and colorimetric GTPase assay. in Methods in enzymology 2006
Show all 2 Pubmed References
Human Monoclonal DNM2 Primary Antibody for IHC, ELISA - ABIN966018
Yoo, Jeong, Kwon, Hur, Park, Han: Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells. in The Journal of biological chemistry 2002
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a new AHI-1 (show AHI1 Antibodies)-BCR-ABL (show ABL1 Antibodies)-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS (show ROS1 Antibodies)-mediated autophagy. Thus, targeting this complex may facilitate eradication of LSCs for curative therapies
dynamin-2, as a tetramer, might help to establish hemi-fusion and stabilizes the pore during HIV-1 fusion.
Data suggest DNM2/RRAGB (show RRAGB Antibodies)- (or DNM2/RRAGC (show RRAGC Antibodies)-)dependent endocytosis of extracellular amino acids (AAs (show FGD1 Antibodies)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB (show RHEB Antibodies) = Ras homolog enriched in brain (show RHEB Antibodies); DNM2 = dynamin II; RRAG = Ras-related GTP binding protein (show RAB10 Antibodies))
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Data demonstrate that dynamin II is required for the E2:ERalpha (show ESR1 Antibodies) signaling of physiological functions and uncovers a role for autophagy in the control of ERalpha (show ESR1 Antibodies) turnover.
This study reported the clinical characteristics, molecular diagnosis strategy, and DNM2 gene mutations of four Chinese Han patients with centronuclear myopathy.
uncover a link between the dynamin 2 function and JNK (show MAPK8 Antibodies) signaling which leads to AP-1 (show FOSB Antibodies) induction
results provide evidence for a novel Arf6 (show ARF6 Antibodies) activation mechanism by Dyn2 through EFA6B (show PSD4 Antibodies) and EFA6D (show PSD3 Antibodies) in CME in a manner dependent upon the GTPase (show RACGAP1 Antibodies) activity of Dyn2
We conclude that DNM2 is a novel negative regulator of NO production in mouse collecting ducts.
In marked contrast to invadopodia, this degradation does not require the action of Src kinase (show CSK Antibodies), Cdc42 (show CDC42 Antibodies) or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation
Loss of Dynamin 2 GTPase (show RACGAP1 Antibodies) function results in microcytic anaemia.
DNM2 mutations cooperate with Lmo2 (show LMO2 Antibodies) T-cell oncogenes by enhancing IL-7 (show IL7 Antibodies) signalling.
Genetic disruption of Dyn2 GTPase (show RACGAP1 Antibodies) activity selectively in hepatic stellate cells enhances fibrogenesis.
Oxidative stress-induced (show SQSTM1 Antibodies) apoptosis and reactive oxygen species production are attenuated by not only Drp1 (show CRMP1 Antibodies) inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes.
Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.
Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis
Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes
DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis.
Thus dynamin (show DNM1 Antibodies) that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes.
Using an inducible knockout mouse model to generate dynamin 1 (show DNM1 Antibodies)- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin (show DNM1 Antibodies).
Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase (show NOS3 Antibodies) activity.
Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
LKT-mediated cell death involve dynamin-2 and cyclophilin D
DNM2-S619L causes disease, in part, by interfering with membrane tubulation
Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
Upregulation of miR (show MYLIP Antibodies)-124 expression corresponded to decreased expression of its target, DNM2, in the Japanese encephalitis virus -infected PK15 cells.
Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (show ACTR2 Antibodies) localization.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
, dynamin 2
, dynamin II