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Equine herpesvirus type 1 pUL56-induced MHC-I endocytosis required dynamin and tyrosine kinase but was independent of clathrin and caveolin-1, the main constituents of the clathrin- and raft/caveola-mediated endocytosis pathways, respectively.
Down-regulation of Dyn1 (show DNM1L ELISA Kits) activity enhances extracellular Nme1 (show NME1 ELISA Kits) in human colon tumor cell lines.
Hypoxic down-regulation of constitutive endocytosis is HIF-independent, and involves caveolin-1 (show CAV1 ELISA Kits)-mediated inhibition of dynamin-dependent, membrane raft endocytosis.
study reports 2 patients with early onset epileptic encephalopathy possessing de novo DNM1 mutations; detected the novel mutation c.127G>A (p.Gly43Ser) in a patient with Lennox-Gastaut syndrome, and a recurrent mutation c.709C>T (p.Arg237Trp) in a patient with West syndrome
The rare variants in DNM1 were significantly associated with smoking status.
Data indicate that stimulation of the dynamin GTPase activity by SH3 domains is determined by its middle domain.
molecular simulations corroborate the bimodal character of dynamin action and indicate radial and axial forces as dominant, although not independent, drivers of hemi-fission and fission membrane- transformations, respectively
Data indicate the dynamics of a dynamin 1-catalysed GTP (show AK3 ELISA Kits) hydrolysis and tube-severing reaction in real time using fluorescence microscopy.
This study identified and confirmed DNM1 protein changes within the postsynaptic density in schizophrenia.
findings support a role for HTT (show HTT ELISA Kits) on dynamin 1 function and ER homoeostasis. Proteolysis-induced alteration of this function may be relevant to disease.
CRISPR-Cas9n-mediated knockout and reconstitution studies establish that dynamin-1 is activated by Akt/GSK3beta signaling in H1299 non-small lung cancer cells.
Dynamin may facilitate Fas (show FAS ELISA Kits)-mediated apoptotic death in the brain, and Hsp70 (show HSP70 ELISA Kits) may protect by preventing this trafficking.
These results suggested that dynamin 1 was susceptible to the aging process, and that a reduction in dynamin 1 may result in hippocampaldependent memory deficits by disrupting endocytosis and the release of neurotransmitters.
Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.
the identification of the oligomerization cycle of dynamin is an attractive potential therapeutic target to treat chronic kidney diseases .
In the developing neurons, there is a dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.
Using an inducible knockout mouse model to generate dynamin 1- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin.
Dynamin 1 is required for memory formation.
As low-level expression of the dynamin 3 (show DNM3 ELISA Kits) gene in these cells could not be excluded, we have now engineered dynamin 1, 2 and 3 triple KO (TKO (show MRPS12 ELISA Kits)) fibroblasts.
Results further implicate dynamin-1 in vesicular protein transport processes relevant to synaptic and post-Golgi pathways and indicate a possible role in photoreceptor stability
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
, dynamin 1
, dynamin-1-like protein
, dynamin, brain
, dynamin-1-like protein-like