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Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT (show ITK ELISA Kits).
IL17RD negatively regulates Toll-like receptor (TLR)-induced responses.
Demonstrate SEF (show TFCP2 ELISA Kits) expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
Downregulation of Dusp6 (show DUSP6 ELISA Kits), Sprouty4 (show SPRY4 ELISA Kits), and Sef (show TFCP2 ELISA Kits)--negative modulators of FGF2 (show FGF2 ELISA Kits)/ERK1/2 (show MAPK1/3 ELISA Kits) signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.
These results reveal Sef-S actives Lys63-linked TAK1 (show MAP3K7 ELISA Kits) polyubiquitination on lysine 209, induces TAK1 (show MAP3K7 ELISA Kits)-mediated JNK (show MAPK8 ELISA Kits) and p38 (show CRK ELISA Kits) activation and also results apoptosis in 293T cells.
FGF17 (show FGF17 ELISA Kits) and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism.
Downregulation of SEF (show TFCP2 ELISA Kits) mRNA is associated with prostate cancer.
Orphan receptor (show NR1D2 ELISA Kits) IL-17RD tunes IL-17A (show IL17A ELISA Kits) signalling and is required for neutrophilia.
This study establishes Sef (show TFCP2 ELISA Kits) as a feedback antagonist of proinflammatory cytokines and highlights its potential to regulate the crosstalk between proinflammatory cytokine receptors and receptor tyrosine kinases.
The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 (show FGF2 ELISA Kits) is increased.
Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock.
Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
these studies indicate that Sef has specific roles in osteoblast and osteoclast lineages and that its absence results in increased osteoblast and osteoclast activity with a net increase in cortical bone mass.
Since expression of IL-17 (show IL17A ELISA Kits) is elevated in 3-month-old MRL/lpr (show FAS ELISA Kits) mice, we suggest that it plays a role in the pathophysiology of autoimmune dacryoadenitis in these mice.
Over-expressing Sef specifically in the lens of transgenic mice led to impaired lens and eye development that resulted in microphthalmia.
Fgf8 (show FGF8 ELISA Kits), Spry2 (show SPRY2 ELISA Kits) and Sef belong to a synexpression group and may functionally interact during mouse embryonic development
Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling
Sef and Sproutys function synergistically to regulate Gbx2 (show GBX2 ELISA Kits) expression in the anterior hindbrain.
Here we demonstrated that both extracellular and transmembrane domains of Sef contributed to Sef-mediated negative regulation of FGF signaling.
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367).
interleukin 17 receptor D
, interleukin-17 receptor D-like
, IL-17 receptor D
, interleukin-17 receptor D
, interleukin-17 receptor-like protein
, sef homolog
, similar expression to FGF genes protein