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Browse our Pellino E3 Ubiquitin Protein Ligase Family Member 3 Proteins (PELI3)

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Pellino E3 Ubiquitin Protein Ligase Family Member 3 Proteins (PELI3)
On www.antibodies-online.com are 4 Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3) Proteins from 3 different suppliers available. Additionally we are shipping Pellino E3 Ubiquitin Protein Ligase Family Member 3 Antibodies (35) and and many more products for this protein. A total of 45 Pellino E3 Ubiquitin Protein Ligase Family Member 3 products are currently listed.
Synonyms:
6030441F14Rik, A930011L17, BC028931, RGD1305989
list all proteins Gene Name GeneID UniProt
PELI3 240518 Q8BXR6
PELI3 246330 Q8N2H9
Rat PELI3 PELI3 309157  

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Pellino E3 Ubiquitin Protein Ligase Family Member 3 Proteins (PELI3) by Origin

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More Proteins for Pellino E3 Ubiquitin Protein Ligase Family Member 3 Interaction Partners

Mouse (Murine) Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3) interaction partners

  1. Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling.

  2. autophagy causes PELI3 degradation during TLR4 (show TLR4 Proteins)-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B (show IL1B Proteins) expression

  3. Pellino3 targets RIP1 (show RALBP1 Proteins) and regulates the pro-apoptotic effects of TNF-alpha (show TNF Proteins).

  4. Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation.

  5. Pellino3 targets the IRF7 (show IRF7 Proteins) pathway and facilitates autoregulation of TLR3 (show TLR3 Proteins)- and viral-induced expression of type I interferons.

Human Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3) interaction partners

  1. The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response.

  2. Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling.

  3. Peptide PEL3 derived from the interleukin-1 receptor-associated kinase (IRAK)1 (show IRAK1 Proteins)-binding motif reveals a distinct phosphothreonine peptide binding preference.

  4. Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation.

  5. Pellino3 is a novel upstream regulator of p38 MAPK (show MAPK14 Proteins) that activates CREB (show CREB1 Proteins) in a p38 (show CRK Proteins)-dependent manner

  6. suggest that Pellino 3b acts as a negative regulator for IL-1 (show IL1A Proteins) signaling by regulating IRAK (show IRAK1 Proteins) degradation through its ubiquitin protein ligase (show UBE2K Proteins) activity [Pellino 3b]

Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3) Protein Profile

Protein Summary

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Pellino E3 Ubiquitin Protein Ligase Family Member 3 (PELI3)

  • pellino 3 (Peli3)
  • pellino E3 ubiquitin protein ligase family member 3 (PELI3)
  • pellino E3 ubiquitin protein ligase family member 3 (Peli3)
  • pellino homolog 3 (Drosophila) (PELI3)
  • 6030441F14Rik protein
  • A930011L17 protein
  • BC028931 protein
  • RGD1305989 protein

Protein level used designations for PELI3

E3 ubiquitin-protein ligase pellino homolog 3 , pellino-3 , protein pellino homolog 3 , pellino homolog 3 , pellino 3

GENE ID SPECIES
240518 Mus musculus
246330 Homo sapiens
309157 Rattus norvegicus
483710 Canis lupus familiaris
504839 Bos taurus
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