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Expression of S100A8 (show S100A8 Proteins), S100A9 (show S100A9 Proteins) and S100A12 is modulated by eicosapentaenoic acid and docosahexaenoic acid during Inflammation in adipose tissue and mononuclear cells.
The binding interface between S100A12 and the V domain of RAGE (show AGER Proteins) has been identified and mapped.
S100A12 functions as a proinflammatory cytokine and activates dermal fibroblasts, causing dermal fibrosis
S100A9 (show S100A9 Proteins) and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 (show S100A9 Proteins) and CXCL1 (show CXCL1 Proteins) may contribute solely in mild pneumonia, and CCL5 (show CCL5 Proteins) and CXCL11 (show CXCL11 Proteins) may contribute in severe pneumonia.
These data suggest that S100A12 is part of an innate and adaptive inducible antimicrobial network that contributes to host defense against mycobacteria in infected macrophages
Among the investigated S100-proteins, S100A12 showed the closest association with disease activity and therapeutic response and might therefore provide a valuable biomarker for psoriasis
the expression of S100A12 protein and mRNA was downregulated in a large number of clinical samples of GC. Low expression of S100A12 exhibited a marked propensity toward the clinicopathologic features such as tumor size, depth of invasion, TNM (show ODZ1 Proteins) stage, Lauren classification, tumor cell differentiation, and poor survival in GC patients.
Serum S100A12 was significantly higher in rheumatoid arthritis patients than controls, and was correlated with disease activity.
Findings suggest that S100 proteins S100A12 and S100A8 (show S100A8 Proteins)/A9 are secreted independently either via distinct mechanisms of secretion or following the activation of different signal transduction pathways.
an elevated serum level of S100A12 was an independent determinant of the progression of abdominal aortic calcification determined by lateral lumbar X-ray in Hemodialysis patients.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
, S100 calcium-binding protein A12 (calgranulin C)
, calcium-binding protein in amniotic fluid 1
, calgranulin C
, extracellular newly identified RAGE-binding protein
, migration inhibitory factor-related protein 6
, neutrophil S100 protein
, protein S100-A12
, S100 calcium-binding protein A12
, RAGE-binding protein
, cornea-associated antigen