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Genetic variants of ABCG2, common and rare, increased the risk of gout. Non-synonymous allelic variants of ABCG2 had a significant effect on earlier onset of gout and the presence of a familial gout history.
ABCG2 polymorphisms were not associated with adverse drug reactions to regorafenib treatment.
Parathryoid hormone down-regulates ABCG2 expression on the plasma membrane to suppress intestinal and renal urate excretion in secondary hyperparathyroidism leading to hyperuricemia.
The first class of homodimeric prodrug dual inhibitors of P-gp (show ABCB4 ELISA Kits) and ABCG2.
ATPase (show DNAH8 ELISA Kits) measurements imply that DCV and Ho are similarly handled by ABCB1 (show ABCB1 ELISA Kits), whereas ABCG2 seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 multidrug transporter
Higher expression of ABCG2 and MRP1 (show MDM4 ELISA Kits), and lower expression of CK19 (show KRT19 ELISA Kits) in papillary thyroid carcinomas with a solid component were associated with higher tumor recurrence rate and shorter disease-free survival.
Using the HPr-1 (show HPSE ELISA Kits)-AR (nontumorigenic) and CWR-R1 (tumorigenic) prostate cell lines, it was demonstrated that inhibiting the ABCG2-mediated androgen efflux, with Ko143 (ABCG2 inhibitor), increased the nuclear AR expression due to elevated intracellular androgen levels.
study concludes that miR (show MLXIP ELISA Kits)-132 regulated SIRT1 (show SIRT1 ELISA Kits)/CREB (show CREB1 ELISA Kits)/ABCG2 signaling pathway contributing to the cisplatin resistance and might serve as a novel therapeutic target against gastric cancer
structure of human ABCG2 determined by cryo-electron microscopy, providing the first high-resolution insight into a human multidrug transporter
ABCG2 rs2231142 predicts poor response to allopurinol in gout patients.
Inherently high expression of ABCG2 in endocardial endothelial cells protects them against apoptosis in presence of anticancer agents.
ABCG2 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
These findings point to a significant role of the ABCG2 Y581S polymorphism in the milk disposition of enterolactone and the endogenous molecules riboflavin and uric acid, which could affect both milk quality and functionality.
The results suggest that a mutation of SCD1 (show SCD ELISA Kits), but not LEPR (show LEPR ELISA Kits) or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
P-gp (show ABCB4 ELISA Kits), Bcrp and Mrp1 (show ABCC1 ELISA Kits) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCG2 in epithelial cells of the bovine rumen.
These results contribute to the role of ABCG2 in cytoprotection and disposition in important tissue barriers and may have important implications for veterinary pharmacotherapy of dairy animals.
Generated cell culture model allows rapid and high-throughput screening of potential ruminant ABCG2 substrate, increasing the understanding of carrier-associated secretion of xenobiotics into milk.
Bovine ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the veterinary antibiotic danofloxacin.
ABCG2 plays a role in mammary epithelial cell proliferation, and functional polymorphisms in this gene may influence the cellular compartment of the mammary gland and potentially milk production.
The effect of the Y581S polymorphism of ABCG2 on transcellular transport of veterinary drugs was studied because this could alter substrate pharmacokinetics and milk residues.
Bcrp1 (Abcg2), the murine orthologue of the ABC transporter Breast Cancer Resistance Protein (BCRP, ABCG2), has at least four alternative promoters that are designated by the corresponding four alternative first exons produced: E1U, E1A (show BCKDHA ELISA Kits), E1B (show BCKDHB ELISA Kits), and E1C. In-silico protocols are presented to predict alternative promoter usage for Bcrp1 (show BANF1 ELISA Kits).
Report novel pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinolones that reverse ABCG2-mediated resistance in cancer cells.
Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1 (show SLC2A9 ELISA Kits), ABCG2, and URAT1 (show SLC22A12 ELISA Kits). Immunostaining for GLUT9 (show SLC2A9 ELISA Kits) was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.
[(18)F]Mefway is modulated by P-gp (show ABCB4 ELISA Kits), and not by Bcrp in rodents.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
Coadministration of ceritinib with a dual ABCB1 (show ABCB1 ELISA Kits) and ABCG2 inhibitor may improve treatment of brain (micro) metastases.
Pparalpha (show PPARA ELISA Kits) complex translocates from the cytoplasm into the nucleus and further recruits coactivators and transcription machinery which induce the transcription of Abcg2 gene and ultimately results in upregulation of Bcrp protein expression and function
Among the ABC (show ABCB6 ELISA Kits) drug transporters, only ABCG2 was expressed at highly increased levels in a mouse G3 medulloblastoma model.
The studies using Bcrp KO mice serve as an estimation of the clinical plasma concentration-time curve changes in ABCG2 421C>A variants for BCRP substrate drugs with the F ratio correcting the systemic clearance change by Bcrp knockout in Bcrp KO mice.
the renal urate excretion was increased in Abcg2-knockout mice
Functional expression of the ABCG2 efflux transporter in rabbit placenta.
ABCG2-dependent dye exclusion undergoes large expansion in explant culture and becomes associated with high colony formation efficiency.
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
ATP-binding cassette, sub-family G, member 2
, breast cancer resistance protein
, ATP-binding cassette sub-family G member 2
, ATP-binding cassette transporter subfamily G member 2
, ATP-binding cassette, sub-family G (WHITE), member 2
, ATP-binding cassette sub-family G member 2-like
, ABC transporter
, ATP-binding cassette transporter G2
, mitoxantrone resistance-associated protein
, multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2
, placenta specific MDR protein
, placenta-specific ATP-binding cassette transporter
, ATP-binding cassette protein G2
, brain multidrug resistance protein
, ATP binding cassette superfamily G number 2 transporter
, breast cancer resistance protein 1 homolog
, mitoxantrone resistance protein 1
, ATP-binding cassette transporter sub-family G member 2