Browse our Aconitase 1 Proteins (ACO1)

Full name:
Aconitase 1, Soluble Proteins (ACO1)
On are 8 Aconitase 1, Soluble (ACO1) Proteins from 5 different suppliers available. Additionally we are shipping Aconitase 1 Antibodies (73) and Aconitase 1 Kits (9) and many more products for this protein. A total of 98 Aconitase 1 products are currently listed.
Aco-1, Aco1, Acon1, ACONS, AI256519, EFE, ETH1, IREB1, IREBP, IREBP1, IRP1, LEACO1, pTOM13, Ratireb, wu:fo75b03
list all proteins Gene Name GeneID UniProt
ACO1 11428 P28271
ACO1 48 P21399
Rat ACO1 ACO1 50655 Q63270

Show all synonyms

Aconitase 1 Proteins (ACO1) by Origin

Select your origin of interest

Top referenced Aconitase 1 Proteins

  1. Human Aconitase 1 Protein expressed in Escherichia coli (E. coli) - ABIN667323 : Salahudeen, Thompson, Ruiz, Ma, Kinch, Li, Grishin, Bruick: An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 2 references for 667323

More Proteins for Aconitase 1 Interaction Partners

Pig (Porcine) Aconitase 1, Soluble (ACO1) interaction partners

  1. Iron increases turnover of ACO1 in kidney cells, while increasing aconitase (show ACO2 Proteins) activity, suggesting that the apoprotein (show APOE Proteins) (aconitase (show ACO2 Proteins)-inactive) form is not exclusively responsible for turnover.

Mouse (Murine) Aconitase 1, Soluble (ACO1) interaction partners

  1. IL-6 (show IL6 Proteins) likely up-regulates IRP1 and DMT1 (show SLC11A2 Proteins) expression and down-regulates FPN1 (show SLC40A1 Proteins) expression in BV2 microglial cells through JNK (show MAPK8 Proteins) signaling pathways

  2. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 (show IDH1 Proteins) and Aco1, enzymes involved in the TCA cycle, were elevated.

  3. The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.

  4. IRP1 and IRP2 (show IREB2 Proteins) mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.

  5. results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism

  6. Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.

  7. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1 (show SLC25A37 Proteins)(gt/gt (show FABP6 Proteins)) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 (show ALAS2 Proteins) mRNA translation and protoporphyrin accumulation

  8. Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (show APP Proteins) mRNA.

  9. Human ACO1 is a moonlighting protein that has both aco (show ACO2 Proteins)nitase enzyme activity as well as an mRNA binding function.

  10. Aco1 is a moonlighting protein that has aconitase (show ACO2 Proteins) activity as well as mRNA binding ability.

Human Aconitase 1, Soluble (ACO1) interaction partners

  1. regulatory circuit involving FBXL5 (show FBXL5 Proteins) and CIA (show ASF1A Proteins) acts through both IRPs to control iron metabolism and promote optimal cell growth

  2. Data suggest that Fe-S cluster of IRP1 plays role in sensing/regulating cellular iron homeostasis; IRP1 alternates between function as cytosolic aconitase [which contains Fe(4)-S(4) cluster in active-site cleft] and function as apoenzyme [which lacks Fe-S cluster] that binds to iron response element stem-loop structures present in several iron regulatory protein transcripts. [REVIEW]

  3. The SNP rs7874815 in the ACO1 gene was strongly associated with survival in pancreatic cancer.

  4. Our results confirm the observation that mitoNEET (show CISD1 Proteins) is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET (show CISD1 Proteins) plays important role in this process.

  5. Data show that IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia.

  6. These in vitro studies suggest that human GLRX3 (show GLRX3 Proteins) is important for cytosolic Fe-S protein (show CDSN Proteins) maturation.

  7. SIRT3 (show SIRT3 Proteins) overexpression decreases TfR1 (show TFRC Proteins) expression by inhibiting IRP1 and represses proliferation in pancreatic cancer cells.

  8. ACO1 gene expression was positively associated with adipogenic markers in subcutaneous and visceral adipose tissue.

  9. ACO1 genetic variation is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy

  10. MitoNEET (show CISD1 Proteins) governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1.

Rabbit Aconitase 1, Soluble (ACO1) interaction partners

  1. Even though the base-specific RNA-binding residues are not part of the aconitase active site, their substitutions can affect the aconitase activity of holo-IRP1, positively or negatively.

Aconitase 1 (ACO1) Protein Profile

Protein Summary

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Alternative names and synonyms associated with Aconitase 1 (ACO1)

  • aconitase 1, soluble (ACO1)
  • aconitase 1, soluble (aco1)
  • aconitase 1, soluble (LOC100227513)
  • 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1)
  • aconitase 1 (Aco1)
  • aconitase 1, soluble (Aco1)
  • ferritin repressor protein (FRP)
  • Aco-1 protein
  • Aco1 protein
  • Acon1 protein
  • ACONS protein
  • AI256519 protein
  • EFE protein
  • ETH1 protein
  • IREB1 protein
  • IREBP protein
  • IREBP1 protein
  • IRP1 protein
  • LEACO1 protein
  • pTOM13 protein
  • Ratireb protein
  • wu:fo75b03 protein

Protein level used designations for Aconitase 1, Soluble Proteins (ACO1)

aconitase 1, soluble , cytoplasmic aconitate hydratase , iron regulatory protein 1 , aconitase 1-like , 1-Aminocyclopropane-1-carboxylic acid oxidase , ACC oxidase 1 , ethylene-forming enzyme , protein pTOM 13 , IRE-BP 1 , citrate hydro-lyase , cytoplasmic aconitase , iron-responsive element-binding protein 1 , IRE-binding protein 1 , Iron responsive element binding protein , aconitate hydratase, cytoplasmic , ferritin repressor protein , iron-responsive element binding protein 1 , IRP1 , aconitase

465034 Pan troglodytes
568448 Danio rerio
100173767 Pongo abelii
705075 Macaca mulatta
100016997 Monodelphis domestica
100216202 Xenopus (Silurana) tropicalis
100227513 Taeniopygia guttata
100368089 Saccoglossus kowalevskii
100555878 Anolis carolinensis
100607117 Nomascus leucogenys
100628006 Sus scrofa
100634468 Amphimedon queenslandica
544052 Solanum lycopersicum
11428 Mus musculus
380269 Xenopus laevis
373916 Gallus gallus
48 Homo sapiens
481576 Canis lupus familiaris
512995 Bos taurus
50655 Rattus norvegicus
100067866 Equus caballus
100009154 Oryctolagus cuniculus
Selected quality suppliers for Aconitase 1 Proteins (ACO1)
Did you look for something else?