Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Identification of Sec71 as a guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) for Arf1 that preferentially interacts with its GDP-bound form. Like Arf1, Sec71 is also important for dendrite pruning, but not for apoptosis of sensory neurons.
Suggest a model in which Arf1/COPI machinery acts to control endoplasmic reticulum-lipid droplet connections for localization of key enzymes of triglyceride storage and catabolism.
ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development.
Sata indicate that the Class I Arf GTPase (show ARL8A ELISA Kits) is a central component in WRC-driven lamellipodium formation.
Results suggest that N-cadherin (show CDH2 ELISA Kits) is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
Experiments using a mutant form of ARF1 affecting GTP (show AK3 ELISA Kits) hydrolysis suggest that ARF1[GTP (show AK3 ELISA Kits)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (show PLIN2 ELISA Kits) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (show PLIN2 ELISA Kits) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM (show CALM1 ELISA Kits)-DR by regulating phosphorylation of p27 (show PAK2 ELISA Kits) at T157 in MM. our data shed new light on the molecular mechanism of CAM (show CALM1 ELISA Kits)-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (show COPA ELISA Kits)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (show ST8SIA2 ELISA Kits)-induced apoptosis. M-COPA (show COPA ELISA Kits) inhibited transport of Stx (show ST8SIA2 ELISA Kits) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (show ARF3 ELISA Kits) as well as Arf6 (show ARF6 ELISA Kits) play important roles in cytokinesis.
ARF1 activates the MAPK (show MAPK1 ELISA Kits) pathway likely using the Golgi as a main platform, which in turn activates the cytoplasmic RSK1 (show RPS6KA1 ELISA Kits), leading to cell proliferation.
Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A (show CHGA ELISA Kits) and regulates secretion of insulin like growth factor 1 (IGF-1 (show IGF1 ELISA Kits)) and is required for anchorage dependent growth.
this study reports the cryo-electron microscopy structures of the Nef- and Arf1-bound AP-1 (show FOSB ELISA Kits) trimer in the active and inactive states.
ARF1A1C is essential for recycling of PIN (show DYNLL1 ELISA Kits) auxin transporters and for various auxin-dependent developmental processes.[BEX1 (show BEX1 ELISA Kits)][ARF1A1C]
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (show ARF5 ELISA Kits)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (show ARF5 ELISA Kits) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
Data show that IAA8 is involved in lateral root formation, and that this process is regulated through the interaction with the TIR1 auxin receptor and ARF transcription factors in the nucleus.
The authors showed that Arf1 interacted with the viral p27 (show CDKN1B ELISA Kits) replication protein within the virus-induced large punctate structures of the endoplasmic reticulum membrane.
unlike arf2 (show ARF4 ELISA Kits) mutations, an arf1 mutation increased transcription of Aux/IAA genes in Arabidopsis flowers, supporting previous biochemical studies that indicated that ARF1 is a transcriptional repressor
The half-life of degradation of ARF1, and its role in auxin metabolism, are reported.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (show TP53 ELISA Kits) delays age-associated central nervous system functional decline.
ARF1/TBCE (show TBCE ELISA Kits)-mediated cross-talk that coordinates COPI formation and tubulin (show TUBB ELISA Kits) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (show LRP6 ELISA Kits) phosphorylation for the transduction of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
termination of Arf1 signals mediated through GGA require that Arf1.GTP (show AK3 ELISA Kits) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 ELISA Kits)
Vascular endothelial growth factor receptor-2 (show KDR ELISA Kits) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (show NOS3 ELISA Kits) activation and nitric oxide release from endothelial cells
Data show that AP-1 (show JUN ELISA Kits) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (show AK3 ELISA Kits) or nonhydrolyzable GTP (show AK3 ELISA Kits)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (show NCS1 ELISA Kits)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (show CA2 ELISA Kits)+)-dependent and ARF-dependent pathways in TGN (show TG ELISA Kits) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (show JUN ELISA Kits) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (show AK3 ELISA Kits).
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 ELISA Kits) in mitochondrial function via its association with several mitochondrial proteins.
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP ribosylation factor at 79F
, ADP-ribosylation factor 1
, tripartite motif-containing 23
, ADP-ribosylation factor domain protein 1
, adp-ribosylation factor 1
, ADP-ribosylation factor 6
, ADP-ribosylation factor GTPase activating protein 3
, ADP-ribosylation factor GTPase activating protein 1