Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
our findings demonstrate that ARF1 is a molecular switch for cancer progression and thus suggest that limiting the expression/activation of this GTPase (show RACGAP1 ELISA Kits) could help improve outcome for breast cancer patients.
changes in distinct lipid ratios may converge on ARF1 to increase SBP-1 (show MEGF8 ELISA Kits)/SREBP-1 (show SREBF1 ELISA Kits) activity.
Experiments using a mutant form of ARF1 affecting GTP (show AK3 ELISA Kits) hydrolysis suggest that ARF1[GTP (show AK3 ELISA Kits)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (show PLIN2 ELISA Kits) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (show PLIN2 ELISA Kits) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM-DR by regulating phosphorylation of p27 (show PAK2 ELISA Kits) at T157 in MM. our data shed new light on the molecular mechanism of CAM-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (show COPA ELISA Kits)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (show ST8SIA2 ELISA Kits)-induced apoptosis. M-COPA (show COPA ELISA Kits) inhibited transport of Stx (show ST8SIA2 ELISA Kits) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (show ARF3 ELISA Kits) as well as Arf6 (show ARF6 ELISA Kits) play important roles in cytokinesis.
ARF1 activates the MAPK (show MAPK1 ELISA Kits) pathway likely using the Golgi as a main platform, which in turn activates the cytoplasmic RSK1 (show RPS6KA1 ELISA Kits), leading to cell proliferation.
Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A (show CHGA ELISA Kits) and regulates secretion of insulin like growth factor 1 (IGF-1 (show IGF1 ELISA Kits)) and is required for anchorage dependent growth.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (show TP53 ELISA Kits) delays age-associated central nervous system functional decline.
ARF1/TBCE (show TBCE ELISA Kits)-mediated cross-talk that coordinates COPI formation and tubulin (show TUBB ELISA Kits) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (show LRP6 ELISA Kits) phosphorylation for the transduction of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
termination of Arf1 signals mediated through GGA require that Arf1.GTP (show AK3 ELISA Kits) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (show AK3 ELISA Kits)
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 ELISA Kits) in mitochondrial function via its association with several mitochondrial proteins.
Vascular endothelial growth factor receptor-2 (show KDR ELISA Kits) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (show NOS3 ELISA Kits) activation and nitric oxide release from endothelial cells
Data show that AP-1 (show JUN ELISA Kits) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (show AK3 ELISA Kits) or nonhydrolyzable GTP (show AK3 ELISA Kits)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (show NCS1 ELISA Kits)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (show CA2 ELISA Kits)+)-dependent and ARF-dependent pathways in TGN (show TG ELISA Kits) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (show JUN ELISA Kits) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (show AK3 ELISA Kits).
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (show ARF5 ELISA Kits)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (show ARF5 ELISA Kits) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor 1
, adp-ribosylation factor 1
, ADP-ribosylation factor domain protein 1